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Determination of the molecular complexation constant between alprostadil and alpha-cyclodextrin by conductometry: implications for a freeze-dried formulation.
J Pharm Biomed Anal. 2005 Oct 4;39(5):877-85. doi: 10.1016/j.jpba.2005.03.046. Epub 2005 Aug 26.
J Pharm Biomed Anal. 2005.
PMID: 16126357
The binding constant between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD) was determined at four temperatures using conductance measurements. Alpha-cyclodextrin is an excipient material in Caverject dual chamber syringe (DCS) that was added to enhance stabil …
The binding constant between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD) was determined at four temperatures using conductance meas …
Determination of the binding constant between alprostadil and alpha-cyclodextrin by capillary electrophoresis: implications for a freeze-dried formulation.
Schipper BR, Ramstad T.
Schipper BR, et al.
J Pharm Sci. 2005 Jul;94(7):1528-37. doi: 10.1002/jps.20380.
J Pharm Sci. 2005.
PMID: 15920771
The binding constant between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD) was determined at three temperatures by capillary electrophoresis. alpha-CD is an excipient material in Caverject Dual Chamber Syringe (DCS), added to enhance stability. The binding co …
The binding constant between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD) was determined at three temperatures by capillary electrop …
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Determination by NMR of the binding constant for the molecular complex between alprostadil and alpha-cyclodextrin. Implications for a freeze-dried formulation.
Ramstad T, Hadden CE, Martin GE, Speaker SM, Teagarden DL, Thamann TJ.
Ramstad T, et al.
Int J Pharm. 2005 May 30;296(1-2):55-63. doi: 10.1016/j.ijpharm.2005.02.018. Epub 2005 Apr 12.
Int J Pharm. 2005.
PMID: 15885455
This constant was used to calculate the fraction PGE1 free upon reconstitution of Caverject dual chamber syringe, indicated for the treatment of erectile dysfunction. ...
This constant was used to calculate the fraction PGE1 free upon reconstitution of Caverject dual chamber syringe, indicated fo …
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