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Year Number of Results
1975 2
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1979 5
1980 3
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1983 2
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1985 10
1986 4
1987 4
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1989 5
1990 5
1991 3
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1995 3
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2004 1
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123 results

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1,2,3-Triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens.
Deng C, Yan H, Wang J, Liu K, Liu BS, Shi YM. Deng C, et al. Eur J Med Chem. 2022 Dec 15;244:114888. doi: 10.1016/j.ejmech.2022.114888. Epub 2022 Oct 29. Eur J Med Chem. 2022. PMID: 36334453 Review.
Notably, several 1,2,3-triazole-containing hybrids which are exemplified by cefatrizine, radezolid and tazobactam have already approved as antibiotics to treat infections caused by various organisms including ESKAPE pathogens and their drug-resistant forms, revealing that …
Notably, several 1,2,3-triazole-containing hybrids which are exemplified by cefatrizine, radezolid and tazobactam have already approv …
The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus: An Updated Review (2020- Present).
Li J, Zhang J. Li J, et al. Curr Top Med Chem. 2022;22(1):41-63. doi: 10.2174/1568026621666211111160332. Curr Top Med Chem. 2022. PMID: 34766892 Review.
In particular, 1,2,3-triazole- and 1,2,4-triazole-containing hybrids have the potential to exert dual or multiple antibacterial mechanisms of action. Moreover, 1,2,3-triazole-cephalosporin hybrid cefatrizine, 1,2,3- triazole-oxazolidinone hybrid radezolid, and 1,2,4-triazo …
In particular, 1,2,3-triazole- and 1,2,4-triazole-containing hybrids have the potential to exert dual or multiple antibacterial mechanisms o …
A minireview of 1,2,3-triazole hybrids with O-heterocycles as leads in medicinal chemistry.
Saroha B, Kumar G, Kumar R, Kumari M, Kumar S. Saroha B, et al. Chem Biol Drug Des. 2022 Dec;100(6):843-869. doi: 10.1111/cbdd.13966. Epub 2021 Oct 11. Chem Biol Drug Des. 2022. PMID: 34592059 Review.
Among these synthesized triazole hybrids, many compounds are available commercially and used for treating different infections/disorders like tazobactam and cefatrizine as potent anti-bacterial agents while isavuconazole and ravuconazole as anti-fungal activities to name a …
Among these synthesized triazole hybrids, many compounds are available commercially and used for treating different infections/disorders lik …
Signal Detection of Adverse Drug Reactions of Cephalosporins Using Data from a National Pharmacovigilance Database.
Choi JY, Choi JH, Kim MG, Rhie SJ. Choi JY, et al. Pharmaceuticals (Basel). 2021 May 2;14(5):425. doi: 10.3390/ph14050425. Pharmaceuticals (Basel). 2021. PMID: 34063258 Free PMC article.
This study detected 472 signals and 114 new signals that are not included on the drug labels. Cefatrizine-corneal edema (PRR, 440.64; ROR, 481.67; IC, 3.84) and cefatrizine-corneal ulceration (PRR, 346.22; ROR, 399.70; IC, 4.40) had the highest PRR, ROR, and IC amon …
This study detected 472 signals and 114 new signals that are not included on the drug labels. Cefatrizine-corneal edema (PRR, 440.64; …
Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.
Yao Z, Li J, Liu Z, Zheng L, Fan N, Zhang Y, Jia N, Lv J, Liu N, Zhu X, Du J, Lv C, Xie F, Liu Y, Wang X, Fei Z, Gao C. Yao Z, et al. Mol Biosyst. 2016 Mar;12(3):729-36. doi: 10.1039/c5mb00848d. Epub 2016 Jan 18. Mol Biosyst. 2016. PMID: 26776155
Subsequently, we screened a series of candidate compounds targeting eEF2K and discovered a novel eEF2K inhibitor (cefatrizine) with an anti-proliferative activity toward breast cancer cells. Moreover, we found that cefatrizine induced ER stress in both MCF-7 and MDA …
Subsequently, we screened a series of candidate compounds targeting eEF2K and discovered a novel eEF2K inhibitor (cefatrizine) with a …
[Synthesis of cefatrizine by recombinant alpha-amino acid ester hydrolase].
Pan J, Wang L, Li D, Ye L. Pan J, et al. Sheng Wu Gong Cheng Xue Bao. 2013 Apr;29(4):501-9. Sheng Wu Gong Cheng Xue Bao. 2013. PMID: 23894823 Chinese.
The effects of temperature, pH and substrates' molar ratio upon the transformation yield of cefatrizine by purified recombinant AEH were investigated. The monomer of AEH was determined as 70 kDa by SDS-PAGE. ...The results pave the way for optimization of the industrial en …
The effects of temperature, pH and substrates' molar ratio upon the transformation yield of cefatrizine by purified recombinant AEH w …
Changing the specificity of α-amino acid ester hydrolase toward para-hydroxyl cephalosporins synthesis by site-directed saturation mutagenesis.
Ye LJ, Wang L, Pan Y, Cao Y. Ye LJ, et al. Biotechnol Lett. 2012 Sep;34(9):1719-24. doi: 10.1007/s10529-012-0955-y. Epub 2012 May 22. Biotechnol Lett. 2012. PMID: 22648687
The mutant V131S with the highest initial rates of synthesis toward three p-hydroxyl cephalosporins showed 23 %, 17 % and 64 % increase in maximum product accumulation of cefadroxil, cefprozil and cefatrizine, respectively....
The mutant V131S with the highest initial rates of synthesis toward three p-hydroxyl cephalosporins showed 23 %, 17 % and 64 % increase in m …
Ionization constants and solubility of compounds involved in enzymatic synthesis of aminopenicillins and aminocephalosporins.
Kurochkina VB, Sklyarenko AV, Satarova JE, Yarotsky SV. Kurochkina VB, et al. Bioprocess Biosyst Eng. 2011 Nov;34(9):1103-17. doi: 10.1007/s00449-011-0560-9. Epub 2011 Jun 23. Bioprocess Biosyst Eng. 2011. PMID: 21698348
The article deals with experimental determination of ionization constants and solubility for the compounds (target products, initial beta-lactams, acylating agents and by-products) involved in enzymatic synthesis of some therapeutically used aminopenicillins and aminocephalospori …
The article deals with experimental determination of ionization constants and solubility for the compounds (target products, initial beta-la …
123 results