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Page 1
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
Nissen SE, Yeomans ND, Solomon DH, Lüscher TF, Libby P, Husni ME, Graham DY, Borer JS, Wisniewski LM, Wolski KE, Wang Q, Menon V, Ruschitzka F, Gaffney M, Beckerman B, Berger MF, Bao W, Lincoff AM; PRECISION Trial Investigators. Nissen SE, et al. N Engl J Med. 2016 Dec 29;375(26):2519-29. doi: 10.1056/NEJMoa1611593. Epub 2016 Nov 13. N Engl J Med. 2016. PMID: 27959716 Free article. Clinical Trial.
In the on-treatment analysis, a primary outcome event occurred in 134 patients in the celecoxib group (1.7%), 144 patients in the naproxen group (1.8%), and 155 patients in the ibuprofen group (1.9%) (hazard ratio for celecoxib vs. naproxen, 0.90; 95% CI, 0.71 to 1. …
In the on-treatment analysis, a primary outcome event occurred in 134 patients in the celecoxib group (1.7%), 144 patients in the nap …
Celecoxib.
Cohen B, Preuss CV. Cohen B, et al. 2023 Mar 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Mar 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30570980 Free Books & Documents.
Celecoxib also has an FDA indication for the management of acute pain in adult women and primary dysmenorrhea. ...This activity reviews the mechanism of action, adverse event profile, toxicity, dosing, pharmacodynamics, and monitoring of celecoxib, pertinent for cli …
Celecoxib also has an FDA indication for the management of acute pain in adult women and primary dysmenorrhea. ...This activity revie …
Celecoxib.
[No authors listed] [No authors listed] 2017 Jan 23. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Jan 23. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643894 Free Books & Documents. Review.
Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) with selectively for inhibition of cycloxgenase-2 (Cox-2), which is widely used in the therapy of arthritis. Celecoxib has been linked to rare instances of idiosyncratic drug induced liver disease....
Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) with selectively for inhibition of cycloxgenase-2 (Cox-2), which is widely …
Celecoxib Therapy and CYP2C9 Genotype.
Dean L, Kane M. Dean L, et al. 2016 Aug 18 [updated 2021 Jan 25]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2016 Aug 18 [updated 2021 Jan 25]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 28520369 Free Books & Documents. Review.
Celecoxib is a "COX-2 inhibitor." The cyclooxygenase (COX) enzymes catalyze pathways that play a key role in the generation of the inflammatory response. Most NSAIDs inhibit both types of cyclooxygenase, COX-1 and COX-2, while celecoxib selectively inhibits COX-2. …
Celecoxib is a "COX-2 inhibitor." The cyclooxygenase (COX) enzymes catalyze pathways that play a key role in the generation of the in …
Celecoxib for the treatment of musculoskeletal arthritis.
Krasselt M, Baerwald C. Krasselt M, et al. Expert Opin Pharmacother. 2019 Oct;20(14):1689-1702. doi: 10.1080/14656566.2019.1645123. Epub 2019 Jul 24. Expert Opin Pharmacother. 2019. PMID: 31339385 Review.
Expert opinion: Celecoxib has been shown to be superior to placebo and equivalent to traditional non-steroidal anti-inflammatory drugs (tNSAIDs). Many studies have been published making celecoxib a good and safe treatment option in particular in moderate arthritis a …
Expert opinion: Celecoxib has been shown to be superior to placebo and equivalent to traditional non-steroidal anti-inflammatory drug …
Celecoxib clinical profile.
Tive L. Tive L. Rheumatology (Oxford). 2000 Dec;39 Suppl 2:21-8; discussion 57-9. doi: 10.1093/rheumatology/39.suppl_2.21. Rheumatology (Oxford). 2000. PMID: 11276798 Review.
For both OA and RA, celecoxib has been shown to be significantly superior in efficacy to placebo and similar in efficacy to traditional non-steroidal anti-inflammatory drugs. ...Additionally, the renal and cardiovascular safety of celecoxib has also become apparent, …
For both OA and RA, celecoxib has been shown to be significantly superior in efficacy to placebo and similar in efficacy to tradition …
Celecoxib in breast cancer prevention and therapy.
Li J, Hao Q, Cao W, Vadgama JV, Wu Y. Li J, et al. Cancer Manag Res. 2018 Oct 26;10:4653-4667. doi: 10.2147/CMAR.S178567. eCollection 2018. Cancer Manag Res. 2018. PMID: 30464589 Free PMC article. Review.
Clinical trials have been implemented on integration treatment of celecoxib and shown encouraging results. Celecoxib could be treated as a potential candidate for antitumor agent. ...In this review, we discuss different mechanisms of anticancer effect of celecoxi …
Clinical trials have been implemented on integration treatment of celecoxib and shown encouraging results. Celecoxib could be …
The Effect of Topical Celecoxib as an Anti-Psoriasis Agent.
Nitescu DA, Paunescu H, Gologan D, Mihai A, Stoian AC, Coman OA. Nitescu DA, et al. Maedica (Bucur). 2022 Dec;17(4):805-811. doi: 10.26574/maedica.2022.17.4.805. Maedica (Bucur). 2022. PMID: 36818260 Free PMC article.
Celecoxib 8% and 4% lead to a statistically significant increase in orthokeratosis degree when compared with celecoxib 2% and tretinoin 0.05%. Along with cyclo-oxygenase inhibition, other mechanisms of action of celecoxib are discussed. This study offers valu …
Celecoxib 8% and 4% lead to a statistically significant increase in orthokeratosis degree when compared with celecoxib 2% and …
Celecoxib for Mood Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Gędek A, Szular Z, Antosik AZ, Mierzejewski P, Dominiak M. Gędek A, et al. J Clin Med. 2023 May 16;12(10):3497. doi: 10.3390/jcm12103497. J Clin Med. 2023. PMID: 37240605 Free PMC article. Review.
We found no conclusive evidence for the effectiveness of celecoxib in bipolar depression. Celecoxib at a dose of 400 mg/d used for up to 12 weeks appeared to be a safe treatment in patients with mood disorders. ...Further studies are needed to evaluate the efficacy …
We found no conclusive evidence for the effectiveness of celecoxib in bipolar depression. Celecoxib at a dose of 400 mg/d used …
Celecoxib inhibits 5-lipoxygenase.
Maier TJ, Tausch L, Hoernig M, Coste O, Schmidt R, Angioni C, Metzner J, Groesch S, Pergola C, Steinhilber D, Werz O, Geisslinger G. Maier TJ, et al. Biochem Pharmacol. 2008 Oct 1;76(7):862-72. doi: 10.1016/j.bcp.2008.07.009. Epub 2008 Jul 19. Biochem Pharmacol. 2008. PMID: 18692027
Similarly, celecoxib inhibited LTB(4) formation in human whole blood (IC(50) approximately 27.3 microM). ...Together, celecoxib is a direct inhibitor of 5-LO in vitro and in vivo. These findings provide a potential molecular basis for some of the described COX-2-ind …
Similarly, celecoxib inhibited LTB(4) formation in human whole blood (IC(50) approximately 27.3 microM). ...Together, celecoxib …
7,525 results