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Asiaticoside Alleviates Cerebral Ischemia-Reperfusion Injury via NOD2/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Factor kappa B (NF-kappaB) Signaling Pathway.
Zhang C, Chen S, Zhang Z, Xu H, Zhang W, Xu D, Lin B, Mei Y. Zhang C, et al. Med Sci Monit. 2020 Feb 1;26:e920325. doi: 10.12659/MSM.920325. Med Sci Monit. 2020. PMID: 32006420 Free PMC article.
BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) remains a serious health problem. ...CONCLUSIONS Asiaticoside showed a protective effect against cerebral ischemia-reperfusion injury via the NOD2/MAPK/NF-kappaB signaling pathway. ...
BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) remains a serious health problem. ...CONCLUSIONS Asiaticoside showed a …
Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia.
Krishnamurthy RG, Senut MC, Zemke D, Min J, Frenkel MB, Greenberg EJ, Yu SW, Ahn N, Goudreau J, Kassab M, Panickar KS, Majid A. Krishnamurthy RG, et al. J Neurosci Res. 2009 Aug 15;87(11):2541-50. doi: 10.1002/jnr.22071. J Neurosci Res. 2009. PMID: 19382233 Free PMC article.
We investigated the neuroprotective effect of asiatic acid in a mouse model of permanent cerebral ischemia. Various doses of asiatic acid (30, 75, or 165 mg/kg) were administered orally at 1 hr pre- and 3, 10, and 20 hr postischemia, and infarct volume and behaviora …
We investigated the neuroprotective effect of asiatic acid in a mouse model of permanent cerebral ischemia. Various doses of a …
Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats.
Luo Y, Yang YP, Liu J, Li WH, Yang J, Sui X, Yuan X, Nie ZY, Liu YQ, Chen D, Lin SH, Wang YA. Luo Y, et al. Brain Res. 2014 May 27;1565:37-47. doi: 10.1016/j.brainres.2014.04.008. Epub 2014 Apr 13. Brain Res. 2014. PMID: 24735651
Madecassoside, a triterpenoid derivative isolated from Centella asiatica, exhibits anti-inflammatory and antioxidant activities. We investigated its neuroprotective effect against ischemia-reperfusion (I/R) injury in cerebral neurons in male Sprague-Dawley ra …
Madecassoside, a triterpenoid derivative isolated from Centella asiatica, exhibits anti-inflammatory and antioxidant activities. We i …
Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism.
Chen S, Yin ZJ, Jiang C, Ma ZQ, Fu Q, Qu R, Ma SP. Chen S, et al. Pharmacol Biochem Behav. 2014 Jul;122:7-15. doi: 10.1016/j.pbb.2014.03.004. Epub 2014 Mar 12. Pharmacol Biochem Behav. 2014. PMID: 24631487
This study was to investigate the effects of AS on memory impairment and inflammatory cytokines expression induced by transient cerebral ischemia and reperfusion in mice, as well as the potential signaling pathway. ...Moreover, AS (20, 40 and 60 mg/kg) markedly redu …
This study was to investigate the effects of AS on memory impairment and inflammatory cytokines expression induced by transient cerebral …
Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders.
Ong WY, Farooqui T, Kokotos G, Farooqui AA. Ong WY, et al. ACS Chem Neurosci. 2015 Jun 17;6(6):814-31. doi: 10.1021/acschemneuro.5b00073. Epub 2015 May 1. ACS Chem Neurosci. 2015. PMID: 25891385 Review.
Neurological disorders including excitotoxicity; traumatic nerve and brain injury; cerebral ischemia; Alzheimer's disease; Parkinson's disease; multiple sclerosis; experimental allergic encephalitis; pain; depression; bipolar disorder; schizophrenia; and auti …
Neurological disorders including excitotoxicity; traumatic nerve and brain injury; cerebral ischemia; Alzheimer's disea …
Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism.
Qiu F, Yuan Y, Luo W, Gong YS, Zhang ZM, Liu ZM, Gao L. Qiu F, et al. Acta Pharmacol Sin. 2022 Jun;43(6):1395-1407. doi: 10.1038/s41401-021-00763-9. Epub 2021 Sep 14. Acta Pharmacol Sin. 2022. PMID: 34522006 Free PMC article.
Myocardial infarction (MI) causes disturbances in myocardial energy metabolism, ultimately leading to a poor prognosis. ...AA has been found to alleviate focal cerebral and liver ischemic injury by reversing mitochondrial dysfunction. ...
Myocardial infarction (MI) causes disturbances in myocardial energy metabolism, ultimately leading to a poor prognosis. ...AA has bee …
Nerve Protective Effect of Asiaticoside against Ischemia-Hypoxia in Cultured Rat Cortex Neurons.
Sun T, Liu B, Li P. Sun T, et al. Med Sci Monit. 2015 Oct 8;21:3036-41. doi: 10.12659/MSM.894024. Med Sci Monit. 2015. PMID: 26447863 Free PMC article.
Asiaticoside can reduce the cerebral infarct size in acute focal cerebral ischemia in a mouse model and asiatic acid glycosides can significantly improve neurobehavioral scores. Currently, there is a lack of understanding of asiaticoside in regard to its neur …
Asiaticoside can reduce the cerebral infarct size in acute focal cerebral ischemia in a mouse model and asiatic acid gl …
Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats.
Tabassum R, Vaibhav K, Shrivastava P, Khan A, Ejaz Ahmed M, Javed H, Islam F, Ahmad S, Saeed Siddiqui M, Safhi MM, Islam F. Tabassum R, et al. Neurol Sci. 2013 Jun;34(6):925-33. doi: 10.1007/s10072-012-1163-1. Epub 2012 Aug 4. Neurol Sci. 2013. PMID: 22864972
Centella asiatica has been used as psychoactive and antioxidant herbal medicine since ancient time. ...Our results revealed that C. asiatica administration greatly improved neurobehavioral activity and diminished infarction volume along with the restored histologica …
Centella asiatica has been used as psychoactive and antioxidant herbal medicine since ancient time. ...Our results revealed that C. a …
Asiaticoside attenuates neonatal hypoxic-ischemic brain damage through inhibiting TLR4/NF-kappaB/STAT3 pathway.
Zhou Y, Wang S, Zhao J, Fang P. Zhou Y, et al. Ann Transl Med. 2020 May;8(10):641. doi: 10.21037/atm-20-3323. Ann Transl Med. 2020. PMID: 32566578 Free PMC article.
BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is currently a leading cause of neonatal death. Asiaticoside (AT), a bioactive constituent isolated from Centella asiatica, possesses numerous biological properties. For instance, previous studies showed that AT co …
BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is currently a leading cause of neonatal death. Asiaticoside (AT), a bioactive co …
Asiatic acid increased locomotor and head width by inducing brain-derived neurotrophic factor in intrauterine hypoxia-exposed zebrafish.
Ariani A, Khotimah H, Nurdiana N, Rahayu M. Ariani A, et al. Open Vet J. 2023 Oct;13(10):1326-1333. doi: 10.5455/OVJ.2023.v13.i10.12. Epub 2023 Oct 31. Open Vet J. 2023. PMID: 38027402 Free PMC article.
BACKGROUND: Hypoxia ischemia leads to abnormal behavior and growth. Prenatal hypoxia also decreases brain adaptive potential, which can cause fatal effects such as cell death. Asiatic acid (AA) in Centella asiatica is a neuroprotector through antioxidant and …
BACKGROUND: Hypoxia ischemia leads to abnormal behavior and growth. Prenatal hypoxia also decreases brain adaptive potential, …
11 results