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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1962 1
1963 6
1964 20
1965 23
1966 21
1967 58
1968 71
1969 64
1970 82
1971 57
1972 62
1973 97
1974 80
1975 107
1976 122
1977 113
1978 138
1979 188
1980 185
1981 280
1982 319
1983 366
1984 356
1985 377
1986 330
1987 292
1988 275
1989 326
1990 325
1991 304
1992 304
1993 306
1994 337
1995 336
1996 324
1997 345
1998 359
1999 354
2000 406
2001 402
2002 423
2003 433
2004 426
2005 428
2006 499
2007 490
2008 505
2009 519
2010 558
2011 582
2012 702
2013 734
2014 899
2015 813
2016 892
2017 949
2018 1048
2019 1112
2020 1219
2021 1289
2022 1433
2023 1326
2024 550

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24,573 results

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Page 1
New Perspectives on Antimicrobial Agents: Cefiderocol.
McCreary EK, Heil EL, Tamma PD. McCreary EK, et al. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0217120. doi: 10.1128/AAC.02171-20. Epub 2021 Jul 16. Antimicrob Agents Chemother. 2021. PMID: 34031052 Free PMC article. Review.
Bacterial resistance to carbapenem agents has reached alarming levels. Accordingly, collaborative efforts between national and international organizations and the pharmaceutical industry have led to an impressive expansion of commercially available beta-lactam agents in re …
Bacterial resistance to carbapenem agents has reached alarming levels. Accordingly, collaborative efforts between national and intern …
The cephalosporins.
Marshall WF, Blair JE. Marshall WF, et al. Mayo Clin Proc. 1999 Feb;74(2):187-95. doi: 10.4065/74.2.187. Mayo Clin Proc. 1999. PMID: 10069359 Review.
The cephalosporins are a large group of related beta-lactam antimicrobial agents. ...As a result of widespread use of cephalosporins, bacterial resistance to these drugs is increasingly common. ...
The cephalosporins are a large group of related beta-lactam antimicrobial agents. ...As a result of widespread use of cephalospori …
Cephalosporins as key lead generation beta-lactam antibiotics.
Lin X, Kück U. Lin X, et al. Appl Microbiol Biotechnol. 2022 Dec;106(24):8007-8020. doi: 10.1007/s00253-022-12272-8. Appl Microbiol Biotechnol. 2022. PMID: 36401643 Free PMC article. Review.
CPC serves as a core compound for producing semi-synthetic cephalosporins that can control infections with different resistance mechanisms. ...Finally, we describe how CPC serves as a key lead generation source for the in vitro and better, in vivo synthesis of 7-ami …
CPC serves as a core compound for producing semi-synthetic cephalosporins that can control infections with different resistance …
Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin.
Sato T, Yamawaki K. Sato T, et al. Clin Infect Dis. 2019 Nov 13;69(Suppl 7):S538-S543. doi: 10.1093/cid/ciz826. Clin Infect Dis. 2019. PMID: 31724047 Free PMC article. Review.
The emergence of antimicrobial resistance is a significant public health issue worldwide, particularly for healthcare-associated infections caused by carbapenem-resistant gram-negative pathogens. Cefiderocol is a novel siderophore cephalosporin targeting gram …
The emergence of antimicrobial resistance is a significant public health issue worldwide, particularly for healthcare-associated infe …
Cefiderocol.
Soriano MC, Montufar J, Blandino-Ortiz A. Soriano MC, et al. Rev Esp Quimioter. 2022 Apr;35 Suppl 1(Suppl 1):31-34. doi: 10.37201/req/s01.07.2022. Epub 2022 Apr 22. Rev Esp Quimioter. 2022. PMID: 35488822 Free PMC article. Review.
Cefiderocol is a new siderophore cephalosporin with potent in vitro activity against gram-negative bacilli including Enterobacterales that produce all kinds of carbapenemases and non-fermenting Gram-negative with difficult-to-treat resistance. ...Cefiderocol is a go …
Cefiderocol is a new siderophore cephalosporin with potent in vitro activity against gram-negative bacilli including Enterobacterales …
Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei.
Hall CM, Somprasong N, Hagen JP, Nottingham R, Sahl JW, Webb JR, Mayo M, Currie BJ, Podin Y, Wagner DM, Keim P, Schweizer HP. Hall CM, et al. Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0017123. doi: 10.1128/aac.00171-23. Epub 2023 May 3. Antimicrob Agents Chemother. 2023. PMID: 37133377 Free PMC article.
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by beta-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resi …
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by beta-lactam and multidrug-resista …
Ceftobiprole medocaril.
Méndez R, Latorre A, González-Jiménez P. Méndez R, et al. Rev Esp Quimioter. 2022 Apr;35 Suppl 1(Suppl 1):25-27. doi: 10.37201/req/s01.05.2022. Epub 2022 Apr 22. Rev Esp Quimioter. 2022. PMID: 35488820 Free PMC article. Review.
Ceftobiprole medocaril is a broad-spectrum 5th-generation cephalosporin with activity against Gram-positives such as methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae, and against Gram-negatives such as Pseudomonas …
Ceftobiprole medocaril is a broad-spectrum 5th-generation cephalosporin with activity against Gram-positives such as methicillin-r …
Cephalosporins 1945-1986.
Abraham EP. Abraham EP. Drugs. 1987;34 Suppl 2:1-14. doi: 10.2165/00003495-198700342-00003. Drugs. 1987. PMID: 3319494 Review.
During a chemical study in 1953, this penicillin was shown to be contaminated with a second substance, cephalosporin C, which contained a beta-lactam ring but was resistant to hydrolysis by a penicillinase (beta-lactamase). At that time, penicillinase-producing Stap …
During a chemical study in 1953, this penicillin was shown to be contaminated with a second substance, cephalosporin C, which contain …
Cefiderocol: Clinical application and emergence of resistance.
Wang L, Zhu J, Chen L, Du H. Wang L, et al. Drug Resist Updat. 2024 Jan;72:101034. doi: 10.1016/j.drup.2023.101034. Epub 2023 Dec 18. Drug Resist Updat. 2024. PMID: 38134561 Review.
Developing new antibiotics has become the critical need for dealing with drug-resistant bacterial infections. Cefiderocol is an iron carrier cephalosporin that achieves drug accumulation through a unique "Trojan horse" strategy into the bacterial periplasm. ...The a …
Developing new antibiotics has become the critical need for dealing with drug-resistant bacterial infections. Cefiderocol is an iron …
Potential Application of Cephalosporins Carried in Organic or Inorganic Nanosystems against Gram-Negative Pathogens.
Bezerra BMS, Dantas de Mendonça Y Araujo SE, Cordeiro de Macêdo A, Costa KMN, Sato MR, Oshiro-Junior JA. Bezerra BMS, et al. Curr Med Chem. 2022 Aug 15;29(31):5212-5229. doi: 10.2174/0929867329666220329201817. Curr Med Chem. 2022. PMID: 35352643 Review.
Commercially, conventional pharmaceutical forms require high doses to ensure clinical efficacy. Additionally, beta-lactam resistance mechanisms, such as the production of enzymes (called extended-spectrum beta-lactamases) and the low plasma half-life of these antibiotics, …
Commercially, conventional pharmaceutical forms require high doses to ensure clinical efficacy. Additionally, beta-lactam resistance …
24,573 results
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