Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial.
De Jong A, Bignon A, Stephan F, Godet T, Constantin JM, Asehnoune K, Sylvestre A, Sautillet J, Blondonnet R, Ferrandière M, Seguin P, Lasocki S, Rollé A, Fayolle PM, Muller L, Pardo E, Terzi N, Ramin S, Jung B, Abback PS, Guerci P, Sarton B, Rozé H, Dupuis C, Cousson J, Faucher M, Lemiale V, Cholley B, Chanques G, Belafia F, Huguet H, Futier E, Azoulay E, Molinari N, Jaber S; EXTUB-OBESE trial group.
De Jong A, et al.
Lancet Respir Med. 2023 Jun;11(6):530-539. doi: 10.1016/S2213-2600(22)00529-X. Epub 2023 Jan 21.
Lancet Respir Med. 2023.
PMID: 36693403
Clinical Trial.
Treatment failure occurred in 66 (13.5%) of 490 patients in the NIV group and in 130 (26.5%) of 491 patients in the oxygen-therapy group (relative risk 0.43; 95% CI 0.31-0.60, p<0.0001). Medical or surgical status did not modify the effect of NIV group on the treatment- …
Treatment failure occurred in 66 (13.5%) of 490 patients in the NIV group and in 130 (26.5%) of 491 patients in the oxygen-therapy group (re …