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Rheumatoid arthritis and citrullination.
Darrah E, Andrade F. Darrah E, et al. Curr Opin Rheumatol. 2018 Jan;30(1):72-78. doi: 10.1097/BOR.0000000000000452. Curr Opin Rheumatol. 2018. PMID: 28937414 Free PMC article. Review.
PURPOSE OF REVIEW: Dysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). ...SUMMARY: Citrullinating enzymes (peptidylarginine dei …
PURPOSE OF REVIEW: Dysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrul …
Interplay of Microbiota and Citrullination in the Immunopathogenesis of Rheumatoid Arthritis.
Alghamdi MA, Redwan EM. Alghamdi MA, et al. Probiotics Antimicrob Proteins. 2022 Feb;14(1):99-113. doi: 10.1007/s12602-021-09802-7. Epub 2021 May 25. Probiotics Antimicrob Proteins. 2022. PMID: 34036479 Review.
On the other hand, its dysbiosis is linked to many human diseases such as rheumatoid arthritis (RA). The RA is an inflammatory autoimmune disorder caused by genetic and environmental factors; microbiota may be considered as a risk environmental factor for it. Cit …
On the other hand, its dysbiosis is linked to many human diseases such as rheumatoid arthritis (RA). The RA is an inflammatory …
Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation.
Kwon EJ, Ju JH. Kwon EJ, et al. Int J Mol Sci. 2021 Sep 30;22(19):10576. doi: 10.3390/ijms221910576. Int J Mol Sci. 2021. PMID: 34638916 Free PMC article. Review.
Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic, environmental, and immunologic factors. Posttranslational modifications (PTMs) such as citrullination, carbamylation, and acetylation are correlated with the pathogenesis …
Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic, environmental, and immunologic factors …
Citrullination by peptidylarginine deiminase in rheumatoid arthritis.
Suzuki A, Yamada R, Yamamoto K. Suzuki A, et al. Ann N Y Acad Sci. 2007 Jun;1108:323-39. doi: 10.1196/annals.1422.034. Ann N Y Acad Sci. 2007. PMID: 17893996 Review.
Rheumatoid arthritis (RA) is a complex, multifactorial disease with genetic and immunological aspects. ...However, levels of anticitrullinated protein antibodies are apparently also increased and were involved in the pathogenesis of autoimmune arthritis in mi …
Rheumatoid arthritis (RA) is a complex, multifactorial disease with genetic and immunological aspects. ...However, levels of a …
Implications of Post-Translational Modifications in Autoimmunity with Emphasis on Citrullination, Homocitrullination and Acetylation for the Pathogenesis, Diagnosis and Prognosis of Rheumatoid Arthritis.
Haro I, Sanmartí R, Gómara MJ. Haro I, et al. Int J Mol Sci. 2022 Dec 13;23(24):15803. doi: 10.3390/ijms232415803. Int J Mol Sci. 2022. PMID: 36555449 Free PMC article. Review.
In this review we summarize the latest findings about the role of PTMs in the generation of autoimmunity and, specifically, we address the most relevant PTMs in rheumatic diseases that occur in synovial tissue. Citrullination, homocitrullination (carbamylation) and acetyla …
In this review we summarize the latest findings about the role of PTMs in the generation of autoimmunity and, specifically, we address the m …
Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis.
Martin M, Nilsson SC, Eikrem D, Fromell K, Scavenius C, Vogt LM, Bielecka E, Potempa J, Enghild JJ, Nilsson B, Ekdahl KN, Kapetanovic MC, Blom AM. Martin M, et al. Front Immunol. 2023 Jun 22;14:1203506. doi: 10.3389/fimmu.2023.1203506. eCollection 2023. Front Immunol. 2023. PMID: 37426666 Free PMC article.
BACKGROUND: Dysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA). ...Citrullination seems to render C1-INH more immunogen …
BACKGROUND: Dysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrull …
Microbial Imbalance and Intestinal Permeability in the Pathogenesis of Rheumatoid Arthritis: A Mechanism Review with a Focus on Bacterial Translocation, Citrullination, and Probiotic Intervention.
Blenkinsopp HC, Seidler K, Barrow M. Blenkinsopp HC, et al. J Am Nutr Assoc. 2024 Jan;43(1):59-76. doi: 10.1080/27697061.2023.2211129. Epub 2023 Jun 9. J Am Nutr Assoc. 2024. PMID: 37294082 Review.
This review aims to investigate the role of intestinal permeability (IP) in rheumatoid arthritis (RA), following the hypotheses that leakage of intestinal microbes can influence increased citrullination of peptides leading to anti-citrullinated protein …
This review aims to investigate the role of intestinal permeability (IP) in rheumatoid arthritis (RA), following the hypothese …
Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire.
Fisher BA, Venables PJ. Fisher BA, et al. Arthritis Res Ther. 2012 Feb 29;14(1):108. doi: 10.1186/ar3740. Arthritis Res Ther. 2012. PMID: 22380578 Free PMC article.
The presence of anti-citrullinated protein/peptide antibodies (ACPA), however, is unique to rheumatoid arthritis. Several lines of evidence suggest that ACPA are important in the pathogenesis of rheumatoid arthritis. A popular hypothesis for thi …
The presence of anti-citrullinated protein/peptide antibodies (ACPA), however, is unique to rheumatoid arthritis. Sever …
Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.
Klareskog L, Malmström V, Lundberg K, Padyukov L, Alfredsson L. Klareskog L, et al. Semin Immunol. 2011 Apr;23(2):92-8. doi: 10.1016/j.smim.2011.01.014. Epub 2011 Mar 3. Semin Immunol. 2011. PMID: 21376627 Review.
This review describes how studies on interactions between genetic variants, and environmental factors, mainly smoking, contribute to the understanding of how autoimmunity to post-translationally (citrullinated) proteins/peptides may occur and potentially contribute to cert …
This review describes how studies on interactions between genetic variants, and environmental factors, mainly smoking, contribute to the und …
The Rheumatoid Arthritis-Associated Citrullinome.
Tilvawala R, Nguyen SH, Maurais AJ, Nemmara VV, Nagar M, Salinger AJ, Nagpal S, Weerapana E, Thompson PR. Tilvawala R, et al. Cell Chem Biol. 2018 Jun 21;25(6):691-704.e6. doi: 10.1016/j.chembiol.2018.03.002. Epub 2018 Apr 5. Cell Chem Biol. 2018. PMID: 29628436 Free PMC article.
Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA), lupus, and cancer. Citrullinated autoantigens, a hallmark of RA, are recognized by anti-citrullinated protein antibodies (ACPAs) which are used t …
Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA), lupus, and cancer. …
5,112 results