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Showing results for colibactin
Your search for coliracin retrieved no results
Colibactin: More Than a New Bacterial Toxin.
Faïs T, Delmas J, Barnich N, Bonnet R, Dalmasso G. Faïs T, et al. Toxins (Basel). 2018 Apr 10;10(4):151. doi: 10.3390/toxins10040151. Toxins (Basel). 2018. PMID: 29642622 Free PMC article. Review.
Despite many efforts, colibactin has not yet been purified, and its structure remains elusive. ...In addition, pksE. coli bacteria increase the number of tumours in diverse colorectal cancer mouse models. Thus, colibactin could have a major impact on human health. I …
Despite many efforts, colibactin has not yet been purified, and its structure remains elusive. ...In addition, pksE. coli bacteria in …
Structure and bioactivity of colibactin.
Wernke KM, Xue M, Tirla A, Kim CS, Crawford JM, Herzon SB. Wernke KM, et al. Bioorg Med Chem Lett. 2020 Aug 1;30(15):127280. doi: 10.1016/j.bmcl.2020.127280. Epub 2020 May 23. Bioorg Med Chem Lett. 2020. PMID: 32527463 Free PMC article. Review.
Colibactin is a secondary metabolite produced by certain strains of bacteria found in the human gut. The presence of colibactin-producing bacteria has been correlated to colorectal cancer in humans. ...
Colibactin is a secondary metabolite produced by certain strains of bacteria found in the human gut. The presence of colibactin …
Shining a Light on Colibactin Biology.
Dougherty MW, Jobin C. Dougherty MW, et al. Toxins (Basel). 2021 May 12;13(5):346. doi: 10.3390/toxins13050346. Toxins (Basel). 2021. PMID: 34065799 Free PMC article. Review.
E. coli harboring this biosynthetic gene cluster cause DNA damage and tumorigenesis in cell lines and pre-clinical models, yet fundamental knowledge regarding colibactin function is lacking. To accurately assess the role of pks(+) E. coli in cancer etiology, the b …
E. coli harboring this biosynthetic gene cluster cause DNA damage and tumorigenesis in cell lines and pre-clinical models, yet fundamental k …
Current understandings of colibactin regulation.
Addington E, Sandalli S, Roe AJ. Addington E, et al. Microbiology (Reading). 2024 Feb;170(2):001427. doi: 10.1099/mic.0.001427. Microbiology (Reading). 2024. PMID: 38314762 Free PMC article. Review.
Colibactin is a potent genotoxic metabolite which causes DNA-damage and which has potential roles in microbial competition and fitness of pks+ bacteria. Colibactin has also been strongly implicated in the development of colorectal cancer. ...
Colibactin is a potent genotoxic metabolite which causes DNA-damage and which has potential roles in microbial competition and fitnes …
Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk.
Dubinsky V, Dotan I, Gophna U. Dubinsky V, et al. Trends Microbiol. 2020 Nov;28(11):874-876. doi: 10.1016/j.tim.2020.05.015. Epub 2020 Jun 5. Trends Microbiol. 2020. PMID: 32507544 Review.
Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with inflammatory bowel dise …
Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colo …
The microbiome-product colibactin hits unique cellular targets mediating host-microbe interaction.
Mousa WK. Mousa WK. Front Pharmacol. 2022 Sep 12;13:958012. doi: 10.3389/fphar.2022.958012. eCollection 2022. Front Pharmacol. 2022. PMID: 36172175 Free PMC article. Review.
In 2022, the Balskus group revealed that colibactin not only hits targets in the eukaryotic cell machinery but also in the prokaryotic cell. ...These unique activities of colibactin highlight its ecological role in shaping gut microbial communities and further conse …
In 2022, the Balskus group revealed that colibactin not only hits targets in the eukaryotic cell machinery but also in the prokaryoti …
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors.
Dougherty MW, Valdés-Mas R, Wernke KM, Gharaibeh RZ, Yang Y, Brant JO, Riva A, Muehlbauer M, Elinav E, Puschhof J, Herzon SB, Jobin C. Dougherty MW, et al. Neoplasia. 2023 Sep;43:100918. doi: 10.1016/j.neo.2023.100918. Epub 2023 Jul 25. Neoplasia. 2023. PMID: 37499275 Free PMC article.
Yet, how colibactin exposure affects the mutational landscape of CRC in vivo remains unclear. ...Collectively, these findings reveal the host response mechanisms underlying colibactin genotoxic activity and suggest that colibactin may exacerbate MMRd-associat …
Yet, how colibactin exposure affects the mutational landscape of CRC in vivo remains unclear. ...Collectively, these findings reveal …
Colibactin: understanding an elusive gut bacterial genotoxin.
Balskus EP. Balskus EP. Nat Prod Rep. 2015 Nov;32(11):1534-40. doi: 10.1039/c5np00091b. Nat Prod Rep. 2015. PMID: 26390983 Review.
This highlight provides an overview of recent progress towards elucidating the structure, biosynthesis, and mode of action of colibactin, a genotoxic secondary metabolite synthesized by human gut bacteria. While isolating colibactin has been problematic, efforts to …
This highlight provides an overview of recent progress towards elucidating the structure, biosynthesis, and mode of action of colibactin …
The bacterial toxin colibactin triggers prophage induction.
Silpe JE, Wong JWH, Owen SV, Baym M, Balskus EP. Silpe JE, et al. Nature. 2022 Mar;603(7900):315-320. doi: 10.1038/s41586-022-04444-3. Epub 2022 Feb 23. Nature. 2022. PMID: 35197633 Free PMC article.
DNA, added exogenously, protects bacteria from colibactin, as does expressing a colibactin resistance protein (ClbS) in non-colibactin-producing cells. The prophage-inducing effects that we observe apply broadly across different phage-bacteria systems and in …
DNA, added exogenously, protects bacteria from colibactin, as does expressing a colibactin resistance protein (ClbS) in non- …
Colibactin-induced genotoxicity and colorectal cancer exacerbation critically depends on adhesin-mediated epithelial binding.
Jans M, Kolata M, Blancke G, Ciers M, Dohlman AB, Kusakabe T, Sze M, Thiran A, Berx G, Tejpar S, van Loo G, Iliev ID, Remaut H, Vereecke L. Jans M, et al. bioRxiv [Preprint]. 2023 Aug 18:2023.08.16.553526. doi: 10.1101/2023.08.16.553526. bioRxiv. 2023. PMID: 37645947 Free PMC article. Preprint.
It remains unclear how the highly unstable colibactin molecule is able to access host epithelial cells and its DNA to cause harm. ...Adhesin-mediated epithelial binding subsequently allows production of the genotoxin colibactin in close proximity to host epithelial …
It remains unclear how the highly unstable colibactin molecule is able to access host epithelial cells and its DNA to cause harm. ... …
333 results