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Showing results for cortistatin l
Your search for cortistamin-l retrieved no results
Structure, function and pharmacology of human itch GPCRs.
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874 Free PMC article.
Here we describe agonist-stabilized structures of MRGPRX2 coupled to G(i1) and G(q) in ternary complexes with the endogenous peptide cortistatin-14 and with a synthetic agonist probe, respectively, and the development of potent antagonist probes for MRGPRX2. ...
Here we describe agonist-stabilized structures of MRGPRX2 coupled to G(i1) and G(q) in ternary complexes with the endogenous peptide cort …
Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes.
Luque RM, Peinado JR, Gracia-Navarro F, Broglio F, Ghigo E, Kineman RD, Malagón MM, Castaño JP. Luque RM, et al. J Mol Endocrinol. 2006 Jun;36(3):547-56. doi: 10.1677/jme.1.01980. J Mol Endocrinol. 2006. PMID: 16720722
As cortistatin, unlike somatostatin, binds to the human receptor for ghrelin/GH secretagogs (GHS-R), we also investigated whether cortistatin stimulates GH release through this receptor by using a synthetic, short form of cortistatin, cortistatin-8 (CS …
As cortistatin, unlike somatostatin, binds to the human receptor for ghrelin/GH secretagogs (GHS-R), we also investigated whether …
Synthesis of cortistatins A, J, K and L.
Flyer AN, Si C, Myers AG. Flyer AN, et al. Nat Chem. 2010 Oct;2(10):886-92. doi: 10.1038/nchem.794. Epub 2010 Aug 1. Nat Chem. 2010. PMID: 20861906 Free PMC article.
Cortistatins A and J, and for the first time K and L, have been synthesized in parallel processes from like intermediates prepared from a single compound. With the identification of facile laboratory transformations linking intermediates in the cortistatin …
Cortistatins A and J, and for the first time K and L, have been synthesized in parallel processes from like intermediates prep …
Cortistatin inhibits calcification of vascular smooth muscle cells by depressing osteoblastic differentiation and endoplasmic reticulum stress.
Liu Y, Lin F, Fu Y, Chen W, Liu W, Chi J, Zhang X, Yin X. Liu Y, et al. Amino Acids. 2016 Nov;48(11):2671-2681. doi: 10.1007/s00726-016-2303-3. Epub 2016 Aug 1. Amino Acids. 2016. PMID: 27480534
Accumulating evidence has indicated that vascular smooth muscular cells (VSMCs) play an important role in the development of vascular calcification (VC). Cortistatin (CST), a novel bio-active peptide, has been shown to exert multiple protective effects on the cardiovascula …
Accumulating evidence has indicated that vascular smooth muscular cells (VSMCs) play an important role in the development of vascular calcif …
Drug design at peptide receptors: somatostatin receptor ligands.
Hannon JP, Nunn C, Stolz B, Bruns C, Weckbecker G, Lewis I, Troxler T, Hurth K, Hoyer D. Hannon JP, et al. J Mol Neurosci. 2002 Feb-Apr;18(1-2):15-27. doi: 10.1385/JMN:18:1-2:15. J Mol Neurosci. 2002. PMID: 11931345 Review.
Recently, a second family of peptides with very similar sequences and features was described; the cortistatins (CST), CST17 and CST29 which are brain selective. The five cloned SRIF receptors (sst1-5) belong to the G-protein coupled/ heptathelical receptor family. ...Nonpe …
Recently, a second family of peptides with very similar sequences and features was described; the cortistatins (CST), CST17 and CST29 …
Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice.
Cordoba-Chacón J, Gahete MD, Pozo-Salas AI, de Lecea L, Castaño JP, Luque RM. Cordoba-Chacón J, et al. Endocrinology. 2016 Jul;157(7):2810-23. doi: 10.1210/en.2016-1195. Epub 2016 May 13. Endocrinology. 2016. PMID: 27175972 Free article.
Cortistatin (CORT) shares high structural and functional similarities with somatostatin (SST) but displays unique sex-dependent pituitary actions. ...
Cortistatin (CORT) shares high structural and functional similarities with somatostatin (SST) but displays unique sex-dependent pitui …
Cortistatin modulates calcitonin gene-related peptide release from neuronal tissues of rat. Comparison with somatostatin.
Capuano A, Currò D, Navarra P, Tringali G. Capuano A, et al. Peptides. 2011 Jan;32(1):138-43. doi: 10.1016/j.peptides.2010.09.018. Epub 2010 Sep 29. Peptides. 2011. PMID: 20883741
Cortistatin (CST) is an endogenous neuropeptide bearing strong structural and functional analogies with somatostatin (SST). ...
Cortistatin (CST) is an endogenous neuropeptide bearing strong structural and functional analogies with somatostatin (SST). ...
Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland.
Deghenghi R, Papotti M, Ghigo E, Muccioli G. Deghenghi R, et al. J Endocrinol Invest. 2001 Jan;24(1):RC1-3. doi: 10.1007/BF03343800. J Endocrinol Invest. 2001. PMID: 11227737
Ghrelin and CST exhibited a similar affinity (4.6-5.4 x 10(-7) mol/l) for the binding while hexarelin was more effective by about four orders of magnitude in displacing 125I-Tyr-Ala-hexarelin. Our data demonstrate for the first time that cortistatin, a natural pepti …
Ghrelin and CST exhibited a similar affinity (4.6-5.4 x 10(-7) mol/l) for the binding while hexarelin was more effective by about fou …
Access to a Guanacastepene and Cortistatin-Related Skeleton via Ethynyl Lactone Ireland-Claisen Rearrangement and Transannular (4 + 3)-Cycloaddition of an Azatrimethylenemethane Diyl.
Zhurakovskyi O, Ellis SR, Thompson AL, Robertson J. Zhurakovskyi O, et al. Org Lett. 2017 Apr 21;19(8):2174-2177. doi: 10.1021/acs.orglett.7b00834. Epub 2017 Apr 11. Org Lett. 2017. PMID: 28398058
The major product of this reaction contains the pentacyclic core common to guanacastepenes D and H and radianspenes J-L; in addition, the central oxa-bridged cycloheptene ring, flanked by two carbocyclic rings, is structurally related to the ABC-ring system found in the …
The major product of this reaction contains the pentacyclic core common to guanacastepenes D and H and radianspenes J-L; in addition, …
International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function.
Vaudry H, Leprince J, Chatenet D, Fournier A, Lambert DG, Le Mével JC, Ohlstein EH, Schwertani A, Tostivint H, Vaudry D. Vaudry H, et al. Pharmacol Rev. 2015;67(1):214-58. doi: 10.1124/pr.114.009480. Pharmacol Rev. 2015. PMID: 25535277 Review.
Phylogenetic studies and synteny analysis indicate that UII and its paralogous peptide urotensin II-related peptide (URP) belong to the somatostatin/cortistatin superfamily. In mammals, the UII and URP genes are primarily expressed in cholinergic neurons of the brainstem a …
Phylogenetic studies and synteny analysis indicate that UII and its paralogous peptide urotensin II-related peptide (URP) belong to the soma …
24 results