Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway.
Wani A, Al Rihani SB, Sharma A, Weadick B, Govindarajan R, Khan SU, Sharma PR, Dogra A, Nandi U, Reddy CN, Bharate SS, Singh G, Bharate SB, Vishwakarma RA, Kaddoumi A, Kumar A.
Wani A, et al.
Autophagy. 2021 Nov;17(11):3813-3832. doi: 10.1080/15548627.2021.1872187. Epub 2021 Jan 19.
Autophagy. 2021.
PMID: 33404280
Free PMC article.
Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-beta (Abeta) plaques and presence of MAPT/tau neurofibrillary tangles. ...In this study, we have identified crocetin, a pharmacologically active co …
Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-beta (A …