Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1966 1
1969 1
1982 1
1984 1
1994 1
1995 2
1996 1
2002 1
2005 1
2006 1
2008 1
2012 1
2013 4
2014 4
2015 1
2016 1
2017 2
2019 4
2021 2
2022 1
2023 2
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

30 results

Results by year

Filters applied: . Clear all
Page 1
Syntheses of hygrine and cuscohygrine.
ANET E, HUGHES GK, et al. ANET E, et al. Nature. 1949 Feb 19;163(4138):289. doi: 10.1038/163289a0. Nature. 1949. PMID: 18224841 No abstract available.
Total synthesis of (+)-dihydrocuscohygrine and cuscohygrine.
Stapper C, Blechert S. Stapper C, et al. J Org Chem. 2002 Sep 6;67(18):6456-60. doi: 10.1021/jo025666l. J Org Chem. 2002. PMID: 12201767
The first enantioselective synthesis of (+)-dihydrocuscohygrine 1 and cuscohygrine 2 is presented. 1 was obtained in nine steps and 30% overall yield with a ruthenium-catalyzed tandem ring rearrangement metathesis key step starting from enantiomerically pure cycloheptene-1 …
The first enantioselective synthesis of (+)-dihydrocuscohygrine 1 and cuscohygrine 2 is presented. 1 was obtained in nine steps and 3 …
Computational insight to putative anti-acetylcholinesterase activity of Commiphora myrrha (Nees), Engler, Burseraceae: a lessen of archaeopharmacology from Mesopotamian Medicine I.
Hussein BA, Karimi I, Yousofvand N. Hussein BA, et al. In Silico Pharmacol. 2019 May 20;7(1):3. doi: 10.1007/s40203-019-0052-1. eCollection 2019. In Silico Pharmacol. 2019. PMID: 31114748 Free PMC article.
In this regard, all terpenoid compounds (25 out of 28) of myrrh were dual inhibitors since they hydrophobically interacted with both catalytic triad and peripheral anionic site (PAS) of AChE while alpha-terpineol, elemol, and eugenol employed hydrogen bonds with AChE. Cuscohyg …
In this regard, all terpenoid compounds (25 out of 28) of myrrh were dual inhibitors since they hydrophobically interacted with both catalyt …
Discrimination between chewing of coca leaves or drinking of coca tea and smoking of "paco" (coca paste) by hair analysis. A preliminary study of possibilities and limitations.
Rubio NC, Krumbiegel F, Pragst F, Thurmann D, Nagel A, Zytowski E, Aranguren M, Gorlelo JC, Poliansky N. Rubio NC, et al. Forensic Sci Int. 2019 Apr;297:171-176. doi: 10.1016/j.forsciint.2019.01.040. Epub 2019 Feb 5. Forensic Sci Int. 2019. PMID: 30798102
BACKGROUND: Hair analysis is a suitable way to discriminate between coca chewers and consumers of manufactured cocaine using the coca alkaloids hygrine (HYG) and cuscohygrine (CUS) as markers. In the present preliminary study it was examined whether CUS and HYG can be dete …
BACKGROUND: Hair analysis is a suitable way to discriminate between coca chewers and consumers of manufactured cocaine using the coca alkalo …
Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense.
Novák M, Salemink CA, Khan I. Novák M, et al. J Ethnopharmacol. 1984 May;10(3):261-74. doi: 10.1016/0378-8741(84)90015-1. J Ethnopharmacol. 1984. PMID: 6379304 Review.
The biological activity of the following alkaloids has been reported in the literature: cocaine, cinnamoylcocaine, benzoylecgonine, methylecgonine, pseudotropine, benzoyltropine, tropacocaine, alpha- and beta-truxilline, hygrine, cuscohygrine and nicotine. The biological a …
The biological activity of the following alkaloids has been reported in the literature: cocaine, cinnamoylcocaine, benzoylecgonine, methylec …
Detection of coca alkaloids in oral fluid from coca leaf (tea) consumers: using solid phase extraction to improve validation parameters and widen the detection window.
Álvarez-Freire I, Cabarcos-Fernández P, Rubio NC, Moreda-Piñeiro A, Tabernero-Duque MJ, Sánchez-Sellero I, Bermejo-Barrera P, Bermejo-Barrera AM. Álvarez-Freire I, et al. Anal Methods. 2023 Nov 23;15(45):6177-6183. doi: 10.1039/d3ay01298k. Anal Methods. 2023. PMID: 37937436
Hygrine and cuscohygrine, two coca leaf alkaloids, have been previously proposed as markers to differentiate legal and illegal cocaine consumption. ...Therefore, researchers are obliged to develop methods to measure coca leaf alkaloids (cuscohygrine, hygrine and t-c …
Hygrine and cuscohygrine, two coca leaf alkaloids, have been previously proposed as markers to differentiate legal and illegal cocain …
1-Methylpyrrolidine-2-acetic Acid is not a Precursor of Tropane Alkaloids.
Huang MN, Abraham TW, Kim SH, Leete E. Huang MN, et al. Phytochemistry. 1996 Feb;41(3):767-73. doi: 10.1016/0031-9422(95)00667-2. Phytochemistry. 1996. PMID: 8835455
Specific incorporation of compounds into ( - )-hyoscyamine, ( - )-scopolamine, ( - )-cocaine and the biosynthetically related cuscohygrine were very low. These results indicate that 1-methylpyrrolidine acid is not an efficient precursor of tropane alkaloids....
Specific incorporation of compounds into ( - )-hyoscyamine, ( - )-scopolamine, ( - )-cocaine and the biosynthetically related cuscohygrin …
Application of hygrine and cuscohygrine as possible markers to distinguish coca chewing from cocaine abuse on WDT and forensic cases.
Rubio NC, Strano-Rossi S, Tabernero MJ, Gonzalez JL, Anzillotti L, Chiarotti M, Bermejo AM. Rubio NC, et al. Forensic Sci Int. 2014 Oct;243:30-4. doi: 10.1016/j.forsciint.2014.02.024. Epub 2014 Mar 6. Forensic Sci Int. 2014. PMID: 24656326
The objectives of present work are twofold. First, we want to verify that hygrine and cuscohygrine are good markers to distinguish between chewing coca leaves and cocaine abuse. ...A GC/MS qualitative method, performed after liquid-liquid extraction, was developed and vali …
The objectives of present work are twofold. First, we want to verify that hygrine and cuscohygrine are good markers to distinguish be …
Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors.
Jaremicz Z, Luczkiewicz M, Kokotkiewicz A, Krolicka A, Sowinski P. Jaremicz Z, et al. Biotechnol Lett. 2014 Apr;36(4):843-53. doi: 10.1007/s10529-013-1426-9. Epub 2013 Dec 10. Biotechnol Lett. 2014. PMID: 24322778 Free PMC article.
The latter gave the highest anisodamine content (0.67 mg/g dry wt) whereas scopolamine, hyoscyamine and cuscohygrine concentrations were highest in the bubble-column reactor (5.3, 1.6 and 26.5 mg/g dry wt, respectively). Both bioreactors gave similar productivities of scop …
The latter gave the highest anisodamine content (0.67 mg/g dry wt) whereas scopolamine, hyoscyamine and cuscohygrine concentrations w …
Hygrine and cuscohygrine as possible markers to distinguish coca chewing from cocaine abuse in workplace drug testing.
Rubio C, Strano-Rossi S, Tabernero MJ, Anzillotti L, Chiarotti M, Bermejo AM. Rubio C, et al. Forensic Sci Int. 2013 Apr 10;227(1-3):60-3. doi: 10.1016/j.forsciint.2012.09.005. Epub 2012 Oct 11. Forensic Sci Int. 2013. PMID: 23063180
Certain alkaloids of the leaves of Erythroxylum coca are lost during the process of extraction/purification of cocaine and it is not possible to find them neither in seizures of chlorhidrate of cocaine nor urine samples of cocaine abusers. These markers are the hygrine and cus …
Certain alkaloids of the leaves of Erythroxylum coca are lost during the process of extraction/purification of cocaine and it is not possibl …
30 results