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Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation.
Deng G, Zhou L, Wang B, Sun X, Zhang Q, Chen H, Wan N, Ye H, Wu X, Sun D, Sun Y, Cheng H. Deng G, et al. J Immunother Cancer. 2022 Oct;10(10):e004874. doi: 10.1136/jitc-2022-004874. J Immunother Cancer. 2022. PMID: 36307151 Free PMC article.
In recent years, there has been increasing research on traditional Chinese medicine in tumor treatment. Cycloastragenol (CAG), an effective active molecule in Astragalus membranaceus, has been found to have antiviral, anti-aging, anti-inflammatory, and other functions. ...
In recent years, there has been increasing research on traditional Chinese medicine in tumor treatment. Cycloastragenol (CAG), an eff …
Cycloastragenol Inhibits Experimental Abdominal Aortic Aneurysm Progression.
Melin LG, Dall JH, Lindholt JS, Steffensen LB, Beck HC, Elkrog SL, Clausen PD, Rasmussen LM, Stubbe J. Melin LG, et al. Biomedicines. 2022 Feb 2;10(2):359. doi: 10.3390/biomedicines10020359. Biomedicines. 2022. PMID: 35203568 Free PMC article.
The pathogenesis of abdominal aortic aneurysm involves vascular inflammation and elastin degradation. Astragalusradix contains cycloastragenol, which is known to be anti-inflammatory and to protect against elastin degradation. We hypothesized that cycloastragenol su …
The pathogenesis of abdominal aortic aneurysm involves vascular inflammation and elastin degradation. Astragalusradix contains cycloastra …
Cycloastragenol: An exciting novel candidate for age-associated diseases.
Yu Y, Zhou L, Yang Y, Liu Y. Yu Y, et al. Exp Ther Med. 2018 Sep;16(3):2175-2182. doi: 10.3892/etm.2018.6501. Epub 2018 Jul 20. Exp Ther Med. 2018. PMID: 30186456 Free PMC article. Review.
Cycloastragenol (CAG) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) ...
Cycloastragenol (CAG) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membran …
Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions.
Ikram M, Jo MH, Choe K, Khan A, Ahmad S, Saeed K, Kim MW, Kim MO. Ikram M, et al. Cells. 2021 Oct 11;10(10):2719. doi: 10.3390/cells10102719. Cells. 2021. PMID: 34685699 Free PMC article.
We also checked the expression of activated microglia and inflammatory cytokines, which showed that cycloastragenol reduced the activated microglia and inflammatory cytokines. Moreover, we evaluated the effects of cycloastragenol against mitochondrial apoptosis and …
We also checked the expression of activated microglia and inflammatory cytokines, which showed that cycloastragenol reduced the activ …
Cycloastragenol exerts protective effects against UVB irradiation in human dermal fibroblasts and HaCaT keratinocytes.
Yang MH, Hwang ST, Um JY, Ahn KS. Yang MH, et al. J Dermatol Sci. 2023 Aug;111(2):60-67. doi: 10.1016/j.jdermsci.2023.07.001. Epub 2023 Jul 4. J Dermatol Sci. 2023. PMID: 37474410
BACKGROUND: Cycloastragenol (CAG) is a triterpene aglycone of astragaloside IV that possesses various pharmacological actions including improving telomerase activity, inhibiting inflammation and cell proliferation, inducing apoptosis. ...
BACKGROUND: Cycloastragenol (CAG) is a triterpene aglycone of astragaloside IV that possesses various pharmacological actions includi …
Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice.
Zhang Y, Gao D, Yuan Y, Zheng R, Sun M, Jia S, Liu J. Zhang Y, et al. Int J Mol Sci. 2023 Mar 31;24(7):6554. doi: 10.3390/ijms24076554. Int J Mol Sci. 2023. PMID: 37047529 Free PMC article.
The pharmacological elimination of SCs with "senolytics" has been emerging as a new therapy for age-related diseases and extending the healthy lifespan. In the present study, we identified that cycloastragenol (CAG), a secondary metabolite isolated from Astragalus membrana …
The pharmacological elimination of SCs with "senolytics" has been emerging as a new therapy for age-related diseases and extending the healt …
Cycloastragenol protects against glucocorticoid-induced osteogenic differentiation inhibition by activating telomerase.
Wu J, Zeng Z, Li Y, Qin H, Zuo C, Zhou C, Xu D. Wu J, et al. Phytother Res. 2021 Apr;35(4):2034-2044. doi: 10.1002/ptr.6946. Epub 2020 Nov 9. Phytother Res. 2021. PMID: 33165990
Glucocorticoid-induced osteoporosis (GIOP) that is mainly featured as low bone density and increased risk of fracture is prone to occur with the administration of excessive glucocorticoids. Cycloastragenol (CAG) has been verified to be a small molecule that activates telom …
Glucocorticoid-induced osteoporosis (GIOP) that is mainly featured as low bone density and increased risk of fracture is prone to occur with …
Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy.
Zhu X, Cao Y, Su M, Chen M, Li C, Yi L, Qin J, Tulake W, Teng F, Zhong Y, Tang W, Wang S, Dong J. Zhu X, et al. Mol Med Rep. 2021 Nov;24(5):805. doi: 10.3892/mmr.2021.12445. Epub 2021 Sep 20. Mol Med Rep. 2021. PMID: 34542166 Free PMC article.
Cycloastragenol (CAG), a secondary metabolite from the roots of Astragalus zahlbruckneri, has been reported to exert anti-inflammatory effects in heart, skin and liver diseases. ...
Cycloastragenol (CAG), a secondary metabolite from the roots of Astragalus zahlbruckneri, has been reported to exert anti-inflammator …
The construction of oligonucleotide-cycloastragenol and the renoprotective effect study.
Tang L, Li X, Qin Y, Geng X, Wang R, Tan W, Mou S. Tang L, et al. Front Bioeng Biotechnol. 2022 Nov 28;10:1027517. doi: 10.3389/fbioe.2022.1027517. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 36518194 Free PMC article.
Astragalus Membranaceus (AM) is the Chinese herbal applied for kidney injury in the clinic, but it remains challenging to further enhance the efficacy. Cycloastragenol (CAG) is the ingredient isolated from AM with poor water solubility, which has shown a renoprotective eff …
Astragalus Membranaceus (AM) is the Chinese herbal applied for kidney injury in the clinic, but it remains challenging to further enhance th …
Anti-aging derivatives of cycloastragenol produced by biotransformation.
Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Chen C, et al. Nat Prod Res. 2021 Aug;35(16):2685-2690. doi: 10.1080/14786419.2019.1662011. Epub 2019 Sep 9. Nat Prod Res. 2021. PMID: 31496283
In this study, the microbial transformation of cycloastragenol (CA) by the fungi Mucor subtilissimus AS 3.2456 and Aspergillus oryzae AS 3.407 yielded 19 metabolites. ...
In this study, the microbial transformation of cycloastragenol (CA) by the fungi Mucor subtilissimus AS 3.2456 and Aspergillus oryzae …
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