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Showing results for cyclized n
Your search for cyclozed-n retrieved no results
N-Edited Guanine Isosteres.
Li X, Romero MD, Tcaturian S, Kurpiewska K, Dömling A. Li X, et al. J Org Chem. 2023 Jul 21;88(14):9823-9834. doi: 10.1021/acs.joc.3c00467. Epub 2023 Jul 11. J Org Chem. 2023. PMID: 37431831 Free PMC article.
Backbone-Cyclized Peptides: A Critical Review.
Rubin SJS, Qvit N. Rubin SJS, et al. Curr Top Med Chem. 2018;18(7):526-555. doi: 10.2174/1568026618666180518092333. Curr Top Med Chem. 2018. PMID: 29773062 Review.
In general, these structures demonstrate improved maintenance of bioactive conformation, stability and cell permeability compared to their linear counterparts, while maintaining support for a variety of side chain chemistries. We explain how backbone cyclization and cyclos …
In general, these structures demonstrate improved maintenance of bioactive conformation, stability and cell permeability compared to their l …
Atropisomeric Properties of N-Acyl/N-Sulfonyl 5H-Dibenzo[b,d]azepin-7(6H)-ones.
Namba T, Hotta M, Tabata H, Makino K, Oshitari T, Natsugari H, Takahashi H. Namba T, et al. J Org Chem. 2021 Jun 4;86(11):7563-7578. doi: 10.1021/acs.joc.1c00594. Epub 2021 May 17. J Org Chem. 2021. PMID: 33998234 Free PMC article.
The stereochemistry of N-acyl/N-sulfonyl 5H-dibenzo[b,d]azepin-7(6H)-ones (I, II) was examined in detail by freezing the conformation with a methyl group at the C-4 of dibenzoazepine. ...For the preparation of 5H-dibenzo[b,d]azepin-7(6H)-one, the intramolecular Frie …
The stereochemistry of N-acyl/N-sulfonyl 5H-dibenzo[b,d]azepin-7(6H)-ones (I, II) was examined in detail by freezing the confo …
Site-Selective Peptide Macrocyclization.
Wills R, Adebomi V, Raj M. Wills R, et al. Chembiochem. 2021 Jan 5;22(1):52-62. doi: 10.1002/cbic.202000398. Epub 2020 Sep 29. Chembiochem. 2021. PMID: 32794268 Review.
Cyclized peptides have seen a rise in popularity in the pharmaceutical industry as drug molecules. ...We will also take an in-depth look at the new exclusively intramolecular N-terminal site-selective CyClick strategy for the synthesis of cyclic peptides. ...
Cyclized peptides have seen a rise in popularity in the pharmaceutical industry as drug molecules. ...We will also take an in-depth l …
Synthesis of Pleuromutilin.
Foy NJ, Pronin SV. Foy NJ, et al. J Am Chem Soc. 2022 Jun 15;144(23):10174-10179. doi: 10.1021/jacs.2c04708. Epub 2022 Jun 2. J Am Chem Soc. 2022. PMID: 35653288 Free PMC article.
The requisite connectivity pattern of the perhydroindanone motif is rapidly established in a sequence of cycloaddition and radical cyclization events. Application of this strategy allows for preparation of the target natural product in 16 steps from commercially available …
The requisite connectivity pattern of the perhydroindanone motif is rapidly established in a sequence of cycloaddition and radical cycliz …
Preparation and Utility of N-Alkynyl Azoles in Synthesis.
Reinus B, Kerwin SM. Reinus B, et al. Molecules. 2019 Jan 24;24(3):422. doi: 10.3390/molecules24030422. Molecules. 2019. PMID: 30682796 Free PMC article. Review.
While much of the chemistry of N-alkynyl azoles mirrors that of the more extensively studied N-alkynyl amides (ynamides), there are notable exceptions. ...In this review, the literature reports of N-alkynyl azole synthesis, reactions, and uses have been assem …
While much of the chemistry of N-alkynyl azoles mirrors that of the more extensively studied N-alkynyl amides (ynamides), ther …
Recombinant expression of backbone-cyclized polypeptides.
Borra R, Camarero JA. Borra R, et al. Biopolymers. 2013 Sep;100(5):502-9. doi: 10.1002/bip.22306. Biopolymers. 2013. PMID: 23893781 Free PMC article. Review.
Here we review the different biochemical approaches available for the expression of backbone-cyclized polypeptides, including peptides and proteins. These methods allow for the production of circular polypeptides either in vitro or in vivo using standard recombinant DNA ex …
Here we review the different biochemical approaches available for the expression of backbone-cyclized polypeptides, including peptide …
N-CF(3) Imidazolidin-2-one Derivatives via Photocatalytic and Silver-Catalyzed Cyclizations.
Turksoy A, Bouayad-Gervais S, Schoenebeck F. Turksoy A, et al. Chemistry. 2022 Aug 16;28(46):e202201435. doi: 10.1002/chem.202201435. Epub 2022 Jun 24. Chemistry. 2022. PMID: 35611709
While the N-trifluoromethylation of cyclic ureas is of interest for the potential to fundamentally change the properties of these biologically relevant moieties, the single synthetic procedure known to date describing their access only gives 4,4-disubstituted or fused arom …
While the N-trifluoromethylation of cyclic ureas is of interest for the potential to fundamentally change the properties of these bio …
Photocatalytic Aerobic Cyclization of N-Propargylamides Enabled by Selenium-pi-Acid Catalysis.
Wang YH, Jiang YQ, Zhang YQ, Ling Y, Ming L, Liu GQ. Wang YH, et al. Chemistry. 2023 Jun 22;29(35):e202300530. doi: 10.1002/chem.202300530. Epub 2023 May 5. Chemistry. 2023. PMID: 36919521
A dual catalytic approach combining photocatalyst and selenium-pi-acid synergy has been used to cyclized of N-propargylamides. This method offers readily access to oxazole aldehydes under chemical oxidant-free conditions with low catalyst loadings, where air acts as …
A dual catalytic approach combining photocatalyst and selenium-pi-acid synergy has been used to cyclized of N-propargylamides. …
Regioselective Base-Mediated Cyclizations of Mono-N-acylpropargylguanidines.
Salvant JM, Edwards AV, Kurek DZ, Looper RE. Salvant JM, et al. J Org Chem. 2017 Jul 7;82(13):6958-6967. doi: 10.1021/acs.joc.7b00639. Epub 2017 Jun 15. J Org Chem. 2017. PMID: 28558466 Free PMC article.
A regioselective base-mediated cyclization of mono-N-acylpropargylguanidines is reported. A related Ag(I)-catalyzed hydroamination strategy was recently employed to yield N(3)-Cbz-protected ene-guanidines, which found utility in the synthesis of naamidine A. …
A regioselective base-mediated cyclization of mono-N-acylpropargylguanidines is reported. A related Ag(I)-catalyzed hydroamina …
12,120 results
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