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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 2
2006 2
2007 1
2008 1
2009 2
2010 6
2011 5
2012 12
2013 16
2014 21
2015 33
2016 33
2017 34
2018 31
2019 25
2020 20
2021 28
2022 29
2023 23
2024 12

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309 results

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Page 1
DAXX-ATRX regulation of p53 chromatin binding and DNA damage response.
Gulve N, Su C, Deng Z, Soldan SS, Vladimirova O, Wickramasinghe J, Zheng H, Kossenkov AV, Lieberman PM. Gulve N, et al. Nat Commun. 2022 Aug 26;13(1):5033. doi: 10.1038/s41467-022-32680-8. Nat Commun. 2022. PMID: 36028493 Free PMC article.
DAXX and ATRX are tumor suppressor proteins that form a histone H3.3 chaperone complex and are frequently mutated in cancers with the alternative lengthening of telomeres (ALT). Here, we show that DAXX and ATRX knock-out (KO) U87-T cells that have acqu …
DAXX and ATRX are tumor suppressor proteins that form a histone H3.3 chaperone complex and are frequently mutated in cancers w …
ATRX/DAXX: Guarding the Genome against the Hazards of ALT.
Clatterbuck Soper SF, Meltzer PS. Clatterbuck Soper SF, et al. Genes (Basel). 2023 Mar 24;14(4):790. doi: 10.3390/genes14040790. Genes (Basel). 2023. PMID: 37107548 Free PMC article. Review.
In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative Lengthening of Telomeres or ALT. The ALT process is linked to mutations in the ATRX/DAXX/H3.3 histone chaperone complex. This …
In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative …
ATRX and DAXX: Mechanisms and Mutations.
Dyer MA, Qadeer ZA, Valle-Garcia D, Bernstein E. Dyer MA, et al. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3):a026567. doi: 10.1101/cshperspect.a026567. Cold Spring Harb Perspect Med. 2017. PMID: 28062559 Free PMC article. Review.
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAXX-mutant tumors. Interestingly, ATRX and DAXX mutations are often found in pediatric tumors, suggesting a particular de …
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/ …
Overview of the 2022 WHO Classification of Neuroendocrine Neoplasms.
Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL. Rindi G, et al. Endocr Pathol. 2022 Mar;33(1):115-154. doi: 10.1007/s12022-022-09708-2. Epub 2022 Mar 16. Endocr Pathol. 2022. PMID: 35294740 Review.
The recognition of highly proliferative, well-differentiated NETs has resulted in the need for biomarkers that can distinguish these G3 NETs from NECs, including stains to determine expression of SSTRs and those that can indicate the unique molecular pathogenetic alterations that …
The recognition of highly proliferative, well-differentiated NETs has resulted in the need for biomarkers that can distinguish these G3 NETs …
Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma.
Fan HC, Chen CM, Chi CS, Tsai JD, Chiang KL, Chang YK, Lin SZ, Harn HJ. Fan HC, et al. Int J Mol Sci. 2019 Jan 8;20(1):200. doi: 10.3390/ijms20010200. Int J Mol Sci. 2019. PMID: 30625996 Free PMC article. Review.
Moreover, some tumors and immortalized cells maintain their telomeres with a telomerase-independent mechanism termed the "alternative lengthening of telomeres" (ALT), which relates to the mutations of the alpha-thalassemia/mental retardation syndrome X-linked protein (ATRX …
Moreover, some tumors and immortalized cells maintain their telomeres with a telomerase-independent mechanism termed the "alternative length …
DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis.
Gisder DM, Overheu O, Keller J, Nöpel-Dünnebacke S, Uhl W, Reinacher-Schick A, Tannapfel A, Tischoff I. Gisder DM, et al. Pathobiology. 2023;90(2):71-80. doi: 10.1159/000524920. Epub 2022 Jun 10. Pathobiology. 2023. PMID: 35691289 Free article.
ATRX- and DAXX-negative PanNETs were further sequenced for mutations. ...Our results indicate that IHC of DAXX and ATRX may identify PanNET subtypes as targets for more aggressive therapy....
ATRX- and DAXX-negative PanNETs were further sequenced for mutations. ...Our results indicate that IHC of DAXX and A …
Prognostic Significance of Altered ATRX/DAXX Gene in Pancreatic Neuroendocrine Tumors: A Meta-Analysis.
Wang F, Xu X, Ye Z, Qin Y, Yu X, Ji S. Wang F, et al. Front Endocrinol (Lausanne). 2021 Jun 18;12:691557. doi: 10.3389/fendo.2021.691557. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34220718 Free PMC article.
And the prognostic significance of altered ATRX/DAXX genes in PanNETs patients have been revealed in several reports. ...CONCLUSIONS: This is the first rigorous pooled analysis assessing ATRX/DAXX mutation as prognostic biomarkers in PanNETs. Patients …
And the prognostic significance of altered ATRX/DAXX genes in PanNETs patients have been revealed in several reports. ...CONCL …
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.
Pinto LM, Pailas A, Bondarchenko M, Sharma AB, Neumann K, Rizzo AJ, Jeanty C, Nicot N, Racca C, Graham MK, Naughton C, Liu Y, Chen CL, Meakin PJ, Gilbert N, Britton S, Meeker AK, Heaphy CM, Larminat F, Van Dyck E. Pinto LM, et al. Nucleic Acids Res. 2024 Feb 9;52(3):1136-1155. doi: 10.1093/nar/gkad1141. Nucleic Acids Res. 2024. PMID: 38038252 Free PMC article.
ATRX and DAXX have also evolved mutually-independent functions in transcription and chromatin dynamics. Here, using paediatric glioma and pancreatic neuroendocrine tumor cell lines, we identify a novel ATRX-independent function for DAXX in promoting ge …
ATRX and DAXX have also evolved mutually-independent functions in transcription and chromatin dynamics. Here, using paediatric …
The diagnostic and prognostic utility of incorporating DAXX, ATRX, and alternative lengthening of telomeres to the evaluation of pancreatic neuroendocrine tumors.
Heaphy CM, Singhi AD. Heaphy CM, et al. Hum Pathol. 2022 Nov;129:11-20. doi: 10.1016/j.humpath.2022.07.015. Epub 2022 Jul 21. Hum Pathol. 2022. PMID: 35872157 Review.
Recent studies have identified alterations in death domain-associated protein 6 (DAXX) and alpha-thalassemia/mental retardation X-linked (ATRX), as well as alternative lengthening of telomeres (ALT), as promising prognostic biomarkers. This review summarizes the ide …
Recent studies have identified alterations in death domain-associated protein 6 (DAXX) and alpha-thalassemia/mental retardation X-lin …
Reprint of: The Diagnostic and Prognostic Utility of Incorporating DAXX, ATRX, and Alternative Lengthening of Telomeres (ALT) to the Evaluation of Pancreatic Neuroendocrine Tumors (PanNETs).
Heaphy CM, Singhi AD. Heaphy CM, et al. Hum Pathol. 2023 Feb;132:1-11. doi: 10.1016/j.humpath.2023.01.004. Epub 2023 Jan 24. Hum Pathol. 2023. PMID: 36702689 Free PMC article. Review.
Recent studies have identified alterations in death domain-associated protein 6 (DAXX) and alpha-thalassemia/mental retardation X-linked (ATRX), as well as alternative lengthening of telomeres (ALT), as promising prognostic biomarkers. This review summarizes the ide …
Recent studies have identified alterations in death domain-associated protein 6 (DAXX) and alpha-thalassemia/mental retardation X-lin …
309 results