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1982 5
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1984 1
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1986 5
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1988 3
1989 6
1990 4
1991 4
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1993 4
1994 6
1995 6
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1997 1
1998 4
1999 4
2000 15
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2002 15
2003 26
2004 25
2005 30
2006 17
2007 26
2008 30
2009 27
2010 17
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Page 1
cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo.
Kato N, Ebihara K, Nogawa T, Futamura Y, Inaba K, Okano A, Aono H, Fujikawa Y, Inoue H, Matsuda K, Osada H, Niwa R, Takahashi S. Kato N, et al. PLoS One. 2023 Aug 31;18(8):e0290851. doi: 10.1371/journal.pone.0290851. eCollection 2023. PLoS One. 2023. PMID: 37651399 Free PMC article.
Decalin-containing tetramic acid is a bioactive scaffold primarily produced by filamentous fungi. ...Compounds that differed only in the decalin configuration were collected from genetically engineered mutants derived from decalin-containing tetramic acid-pro …
Decalin-containing tetramic acid is a bioactive scaffold primarily produced by filamentous fungi. ...Compounds that differed only in …
Enzymatic cis-Decalin Formation in Natural Product Biosynthesis.
Ohashi M, Tan D, Lu J, Jamieson CS, Kanayama D, Zhou J, Houk KN, Tang Y. Ohashi M, et al. J Am Chem Soc. 2023 Feb 15;145(6):3301-3305. doi: 10.1021/jacs.2c12854. Epub 2023 Feb 1. J Am Chem Soc. 2023. PMID: 36723171 Free PMC article.
Stereoselective synthesis of cis-decalin structures using [4 + 2] cycloaddition is challenging. We explored the biosynthetic pathway of the fungal natural product fischerin (1) to identify a new pericyclase FinI that can catalyze such a reaction. The cocrystal structure of …
Stereoselective synthesis of cis-decalin structures using [4 + 2] cycloaddition is challenging. We explored the biosynthetic pathway …
Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels-Alderases.
Watanabe K, Sato M, Osada H. Watanabe K, et al. Fungal Biol Biotechnol. 2022 Apr 29;9(1):9. doi: 10.1186/s40694-022-00139-6. Fungal Biol Biotechnol. 2022. PMID: 35488322 Free PMC article. Review.
This review will cover the DAases involved in the biosynthesis of decalin moieties, which are found in many of the medicinally important natural products, especially those produced by fungi. In particular, we will focus on a subset of secondary metabolites referred to as p …
This review will cover the DAases involved in the biosynthesis of decalin moieties, which are found in many of the medicinally import …
Natural products containing 'decalin' motif in microorganisms.
Li G, Kusari S, Spiteller M. Li G, et al. Nat Prod Rep. 2014 Sep;31(9):1175-201. doi: 10.1039/c4np00031e. Nat Prod Rep. 2014. PMID: 24984916 Review.
This review surveys the natural decalin-type compounds that have been isolated from microorganisms, with emphasis on both chemical and biological implications. Total syntheses of some important decalin moiety-containing natural products are also highlighted....
This review surveys the natural decalin-type compounds that have been isolated from microorganisms, with emphasis on both chemical an …
Two New Cytotoxic Decalin Derivatives from Marine-Derived Fungus Talaromyces sp.
Liu G, Huo R, Niu S, Song F, Liu L. Liu G, et al. Chem Biodivers. 2022 Mar;19(3):e202100990. doi: 10.1002/cbdv.202100990. Epub 2022 Jan 27. Chem Biodivers. 2022. PMID: 35083850
Two new decalin derivatives named fusarielins O (1) and P (2), together with seven known compounds (3-9) were isolated from the crude extract of the marine-derived fungus Talaromyces sp. ...
Two new decalin derivatives named fusarielins O (1) and P (2), together with seven known compounds (3-9) were isolated from the crude …
Stereoselective Synthesis of trans-Decalin-Based Spirocarbocycles via Photocyclization of 1,2-Diketones.
Chen S, Zhang Z, Jiang C, Zhao C, Luo H, Huang J, Yang Z. Chen S, et al. ACS Omega. 2021 Jul 13;6(29):18848-18859. doi: 10.1021/acsomega.1c02054. eCollection 2021 Jul 27. ACS Omega. 2021. PMID: 34337224 Free PMC article.
Diastereoselective synthesis of the trans-decalin-based alpha-hydroxyl butanone spirocarbocycles bearing all-carbon quaternary stereogenic centers has been achieved via Norrish-Yang photocyclization of trans-decalin-substituted-2,3-butanediones using daylight. ...Th …
Diastereoselective synthesis of the trans-decalin-based alpha-hydroxyl butanone spirocarbocycles bearing all-carbon quaternary stereo …
A Novel Decalin-Based Bicyclic Scaffold for FKBP51-Selective Ligands.
Feng X, Sippel C, Knaup FH, Bracher A, Staibano S, Romano MF, Hausch F. Feng X, et al. J Med Chem. 2020 Jan 9;63(1):231-240. doi: 10.1021/acs.jmedchem.9b01157. Epub 2019 Dec 18. J Med Chem. 2020. PMID: 31800244
By using a structure-based rigidification strategy, we hereby report the design and synthesis of a novel promising bicyclic scaffold for FKBP51 ligands. The structure-activity analysis revealed the decalin scaffold as the best moiety for the selectivity-enabling subpocket …
By using a structure-based rigidification strategy, we hereby report the design and synthesis of a novel promising bicyclic scaffold for FKB …
Stereoselective Synthesis of Spiro-Decalin Oxindole Derivatives via Sequential Organocatalytic Michael-Domino Michael/Aldol Reaction.
Straminelli L, Vicentini F, Di Sabato A, Montone CM, Cavaliere C, Rissanen K, Leonelli F, Vetica F. Straminelli L, et al. J Org Chem. 2022 Aug 5;87(15):10454-10461. doi: 10.1021/acs.joc.2c01046. Epub 2022 Jul 25. J Org Chem. 2022. PMID: 35875873 Free PMC article.
Under sequential organocatalysis performed by a pyrrolidine-based organocatalyst and DBU, a highly atom-economical Michael-domino Michael/aldol reaction sequence was optimized, yielding variously functionalized spiro-decalin oxindoles with excellent stereoselectivity (> …
Under sequential organocatalysis performed by a pyrrolidine-based organocatalyst and DBU, a highly atom-economical Michael-domino Michael/al …
Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058.
Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahashi S, Koshino H, Osada H. Nogawa T, et al. J Antibiot (Tokyo). 2023 Jun;76(6):346-350. doi: 10.1038/s41429-023-00613-2. Epub 2023 Apr 5. J Antibiot (Tokyo). 2023. PMID: 37020042
A new decalin-containing secondary metabolite, wakodecaline C, was isolated from a fungus Pyrenochaetopsis sp. ...Wakodecaline C has unique structural features containing a tetrahydrofuran-fused decalin skeleton and tetramic acid moiety, which are connected through …
A new decalin-containing secondary metabolite, wakodecaline C, was isolated from a fungus Pyrenochaetopsis sp. ...Wakodecaline C has …
alpha-Pyrone and decalin derivatives from the marine-derived fungus Trichoderma harzianum PSU-MF79.
Nuansri S, Rukachaisirikul V, Rungwirain N, Kaewin S, Yimnual C, Phongpaichit S, Preedanon S, Sakayaroj J, Muanprasat C. Nuansri S, et al. Nat Prod Res. 2022 Nov;36(21):5462-5469. doi: 10.1080/14786419.2021.2015593. Epub 2021 Dec 13. Nat Prod Res. 2022. PMID: 34894887
Two new compounds, one alpha-pyrone (trichoharzianone) and one decalin (trichoharzianin), along with eight known compounds including three decalins, two delta-lactones, two carboxylic acids and one isochroman were isolated from the marine-derived fungus Trichoderma …
Two new compounds, one alpha-pyrone (trichoharzianone) and one decalin (trichoharzianin), along with eight known compounds including …
728 results