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Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its alpha, beta-unsaturated carbonyl and Keap1.
Ohnishi M, Urasaki T, Egusa K, Kunobu C, Harada T, Shinkado R, Nishi H, Maehara S, Kitamura C, Hata T, Ohashi K, Shibuya H, Inoue A. Ohnishi M, et al. Phytother Res. 2018 May;32(5):892-897. doi: 10.1002/ptr.6028. Epub 2018 Jan 22. Phytother Res. 2018. PMID: 29356228
Dehydrocurdione was extracted from the rhizome of Curcuma sp., and its purity was verified by high performance liquid chromatography. Treatment with 10-100 muM dehydrocurdione transiently and concentration-dependently increased HO-1 mRNA and protein levels. ...
Dehydrocurdione was extracted from the rhizome of Curcuma sp., and its purity was verified by high performance liquid chromatography. …
Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene.
Yoshioka T, Fujii E, Endo M, Wada K, Tokunaga Y, Shiba N, Hohsho H, Shibuya H, Muraki T. Yoshioka T, et al. Inflamm Res. 1998 Dec;47(12):476-81. doi: 10.1007/s000110050361. Inflamm Res. 1998. PMID: 9892041
A higher dose (200 mg/kg) of dehydrocurdione was required to inhibit the carrageenan-induced paw edema. Oral administration of dehydrocurdione at 120 mg/kg/day for 12 days significantly reduced chronic adjuvant arthritis. ...
A higher dose (200 mg/kg) of dehydrocurdione was required to inhibit the carrageenan-induced paw edema. Oral administration of deh …
A Ca(2+) channel blocker-like effect of dehydrocurdione on rodent intestinal and vascular smooth muscle.
Irie K, Yoshioka T, Nakai A, Ochiai K, Nishikori T, Wu GR, Shibuya H, Muraki T. Irie K, et al. Eur J Pharmacol. 2000 Sep 8;403(3):235-42. doi: 10.1016/s0014-2999(00)00445-3. Eur J Pharmacol. 2000. PMID: 10973625
Dehydrocurdione (0.1-3 mM) induced a sustained relaxation of rat duodenum and inhibited spontaneous motility. ...Dehydrocurdione (1 mM) significantly reduced the high K(+)-stimulated increase in cytosolic Ca(2+) level of Fura-2-loaded mesenteric artery from rats. .. …
Dehydrocurdione (0.1-3 mM) induced a sustained relaxation of rat duodenum and inhibited spontaneous motility. ...Dehydrocurdione …
Sesquiterpenes from Curcuma comosa.
Qu Y, Xu F, Nakamura S, Matsuda H, Pongpiriyadacha Y, Wu L, Yoshikawa M. Qu Y, et al. J Nat Med. 2009 Jan;63(1):102-4. doi: 10.1007/s11418-008-0282-8. Epub 2008 Jul 29. J Nat Med. 2009. PMID: 18663560
From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocur …
From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furano …
Anti-inflammatory sesquiterpenes from Curcuma zedoaria.
Makabe H, Maru N, Kuwabara A, Kamo T, Hirota M. Makabe H, et al. Nat Prod Res. 2006 Jun;20(7):680-5. doi: 10.1080/14786410500462900. Nat Prod Res. 2006. PMID: 16901812 Free article.
From the methanolic extract of the rhizome of Curcuma zedoaria, we isolated anti-inflammatory sesquiterpene furanodiene (1) and furanodienone (2) along with new sesquiterpene compound 3 and known eight sesquiterpenes, zederone (4), curzerenone (5), curzeone (6), germacrone (7), 1 …
From the methanolic extract of the rhizome of Curcuma zedoaria, we isolated anti-inflammatory sesquiterpene furanodiene (1) and furanodienon …
Cytotoxic constituents from the rhizomes of Curcuma zedoaria.
Ahmed Hamdi OA, Syed Abdul Rahman SN, Awang K, Abdul Wahab N, Looi CY, Thomas NF, Abd Malek SN. Ahmed Hamdi OA, et al. ScientificWorldJournal. 2014;2014:321943. doi: 10.1155/2014/321943. Epub 2014 Jul 13. ScientificWorldJournal. 2014. PMID: 25126594 Free PMC article.
Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial (1), dehydrocurdione (2), curcumenone (3), comosone II (4), curcumenol (5), procurcumenol (6), germacrone (7), zerumbone epoxide …
Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 d …
Bioactive chemical constituents from Curcuma caesia Roxb. rhizomes and inhibitory effect of curcuzederone on the migration of triple-negative breast cancer cell line MDA-MB-231.
Al-Amin M, Eltayeb NM, Khairuddean M, Salhimi SM. Al-Amin M, et al. Nat Prod Res. 2021 Sep;35(18):3166-3170. doi: 10.1080/14786419.2019.1690489. Epub 2019 Nov 15. Nat Prod Res. 2021. PMID: 31726856
The chromatographic separation afforded germacrone (1), zerumbone (2), furanodienone (3), curzerenone (4), curcumenol (5), zederone (6), curcumenone (7), dehydrocurdione (8) from hexanes fraction and curcuminol G (9), curcuzederone (10), (1S, 10S), (4S,5S)-germacrone-1 (10 …
The chromatographic separation afforded germacrone (1), zerumbone (2), furanodienone (3), curzerenone (4), curcumenol (5), zederone (6), cur …
Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.
Suphrom N, Pumthong G, Khorana N, Waranuch N, Limpeanchob N, Ingkaninan K. Suphrom N, et al. Fitoterapia. 2012 Jul;83(5):864-71. doi: 10.1016/j.fitote.2012.03.017. Epub 2012 Mar 21. Fitoterapia. 2012. PMID: 22465508
Six sesquiterpenes: germacrone (1), zederone (2), dehydrocurdione (3), curcumenol (4), zedoarondiol (5) and isocurcumenol (6) were isolated from rhizomes of Curcuma aeruginosa Roxb. ...
Six sesquiterpenes: germacrone (1), zederone (2), dehydrocurdione (3), curcumenol (4), zedoarondiol (5) and isocurcumenol (6) were is …
Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha.
Morikawa T, Matsuda H, Ninomiya K, Yoshikawa M. Morikawa T, et al. Biol Pharm Bull. 2002 May;25(5):627-31. doi: 10.1248/bpb.25.627. Biol Pharm Bull. 2002. PMID: 12033504 Free article.
To clarify the active compounds, the principal constituents were examined and 11 sesquiterpenes (furanodiene, curdione, neocurdrione, dehydrocurdione, germacrone, 13-hydroxygermacrone, curcumenol, isocurcumenol, aerugidiol, zedoarondiol, and curcumenone) and a diarylheptan …
To clarify the active compounds, the principal constituents were examined and 11 sesquiterpenes (furanodiene, curdione, neocurdrione, deh …
Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.).
Anuchapreeda S, Khumpirapang N, Rupitiwiriya K, Tho-Iam L, Saiai A, Okonogi S, Usuki T. Anuchapreeda S, et al. Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414. doi: 10.1016/j.bmcl.2017.12.029. Epub 2017 Dec 13. Bioorg Med Chem Lett. 2018. PMID: 29274817
The four isolated compounds were identified as furanodiene (1), dehydrocurdione (2), germacrone-4,5-epoxide (3), and zedoarondiol (4). ...
The four isolated compounds were identified as furanodiene (1), dehydrocurdione (2), germacrone-4,5-epoxide (3), and zedoarondiol (4) …
12 results