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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1967 1
1970 3
1972 1
1977 1
1978 2
1979 1
1981 2
1983 2
1984 5
1985 5
1987 2
1989 3
1990 1
1991 1
1992 3
1993 5
1994 1
1995 3
1996 2
1997 6
1998 8
1999 4
2000 5
2001 6
2002 9
2003 9
2004 12
2005 6
2006 10
2007 9
2008 8
2009 6
2010 13
2011 10
2012 15
2013 12
2014 23
2015 18
2016 25
2017 15
2018 21
2019 24
2020 31
2021 19
2022 20
2023 17
2024 11

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389 results

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Page 1
Deuterium Depletion Inhibits Cell Proliferation, RNA and Nuclear Membrane Turnover to Enhance Survival in Pancreatic Cancer.
Boros LG, Somlyai I, Kovács BZ, Puskás LG, Nagy LI, Dux L, Farkas G, Somlyai G. Boros LG, et al. Cancer Control. 2021 Jan-Dec;28:1073274821999655. doi: 10.1177/1073274821999655. Cancer Control. 2021. PMID: 33760674 Free PMC article.
The effects of deuterium-depleted water (DDW) containing deuterium (D) at a concentration of 25 parts per million (ppm), 50 ppm, 105 ppm and the control at 150 ppm were monitored in MIA-PaCa-2 pancreatic cancer cells by the real-time cell impedance detection …
The effects of deuterium-depleted water (DDW) containing deuterium (D) at a concentration of 25 parts per million (ppm) …
Short term deuterium depletion in drinking water reduced tumor induced oxidative stress in mice liver.
Bayrak BB, Kulak GY, Yanardag R, Yarat A. Bayrak BB, et al. Pathol Res Pract. 2022 Dec;240:154186. doi: 10.1016/j.prp.2022.154186. Epub 2022 Oct 26. Pathol Res Pract. 2022. PMID: 36327814
The aim of current work was able to show the oxidant effect of cancer cells found in any part of the body on the liver and to investigate the possible protective effect of deuterium-depleted water (DDW) on this oxidant effect by determining of some liver parameters. …
The aim of current work was able to show the oxidant effect of cancer cells found in any part of the body on the liver and to investigate th …
Deuterium-depletion has no significant impact on the mutation rate of Escherichia coli, deuterium abundance therefore has a probabilistic, not deterministic effect on spontaneous mutagenesis.
Ajibola W, Karcagi I, Somlyai G, Somlyai I, Fehér T. Ajibola W, et al. PLoS One. 2021 Mar 8;16(3):e0243517. doi: 10.1371/journal.pone.0243517. eCollection 2021. PLoS One. 2021. PMID: 33684107 Free PMC article.
Deuterium (D), the second most abundant isotope of hydrogen is present in natural waters at an approximate concentration of 145-155 ppm (ca. 1.5E-4 atom/atom). ...Out of 15 pair-wise fluctuation analyses, nine indicated a significant decrease, while three marked the signif …
Deuterium (D), the second most abundant isotope of hydrogen is present in natural waters at an approximate concentration of 145-155 p …
Emerging Role of Deuterium/Protium Disbalance in Cell Cycle and Apoptosis.
Yaglova NV, Timokhina EP, Obernikhin SS, Yaglov VV. Yaglova NV, et al. Int J Mol Sci. 2023 Feb 4;24(4):3107. doi: 10.3390/ijms24043107. Int J Mol Sci. 2023. PMID: 36834518 Free PMC article. Review.
Deuterium, a stable isotope of hydrogen, is a component of water and organic compounds. ...The review summarizes reported data on the proliferation and apoptosis of normal and neoplastic cells in different modes of deuteration and deuterium depletion in vivo …
Deuterium, a stable isotope of hydrogen, is a component of water and organic compounds. ...The review summarizes reported data on the …
Effects of Deuterium Depletion on Age-Declining Thymopoiesis In Vivo.
Yaglova NV, Obernikhin SS, Timokhina EP, Tsomartova DA, Yaglov VV, Nazimova SV, Tsomartova ES, Ivanova MY, Chereshneva EV, Lomanovskaya TA. Yaglova NV, et al. Biomedicines. 2024 Apr 25;12(5):956. doi: 10.3390/biomedicines12050956. Biomedicines. 2024. PMID: 38790918 Free PMC article.
The present investigation was aimed at evaluating how prolonged deuterium depletion affects morphogenetic processes and the physiological transition of the thymus to age-related involution. The study was performed on 60 male Wistar rats subjected to consumption of …
The present investigation was aimed at evaluating how prolonged deuterium depletion affects morphogenetic processes and the ph …
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.
Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. Ghergurovich JM, et al. Nat Chem Biol. 2020 Jul;16(7):731-739. doi: 10.1038/s41589-020-0533-x. Epub 2020 May 11. Nat Chem Biol. 2020. PMID: 32393898 Free PMC article.
The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD). Here we develop metabolite reporter and deuterium tracer assays to monitor cellular G6PD activity. Using these, we show that the most widely cited …
The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD). Here we devel …
Impact of Reduced Deuterium Intake on Thermoregulation.
Yaglova NV, Obernikhin SS, Timokhina EP, Diatropova MA, Diatropov ME, Yaglov VV. Yaglova NV, et al. Bull Exp Biol Med. 2021 Sep;171(5):572-575. doi: 10.1007/s10517-021-05271-8. Epub 2021 Oct 7. Bull Exp Biol Med. 2021. PMID: 34617175
In 7 days, fluctuations of body temperature, locomotor activity, and oxygen uptake were assessed. Deuterium depletion in the body reduced the mean value of minute fluctuations of body temperature and the mean spectral density of minute fluctuations in body temperatu …
In 7 days, fluctuations of body temperature, locomotor activity, and oxygen uptake were assessed. Deuterium depletion in the b …
AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.
Wu C, Dai C, Li X, Sun M, Chu H, Xuan Q, Yin Y, Fang C, Yang F, Jiang Z, Lv Q, He K, Qu Y, Zhao B, Cai K, Zhang S, Sun R, Xu G, Zhang L, Sun S, Liu Y. Wu C, et al. Theranostics. 2022 Nov 7;12(18):7681-7698. doi: 10.7150/thno.74974. eCollection 2022. Theranostics. 2022. PMID: 36451864 Free PMC article.
Biological function of AKR1C3 was evaluated by CRISPR/Cas9-based gene editing. Isotopic tracing analysis with deuterium(3)-labeled palmitate or carbon13-labeled glucose was conducted to investigate fatty acid (FA) and glucose carbon flux. ...Using multi-omics analysis in c …
Biological function of AKR1C3 was evaluated by CRISPR/Cas9-based gene editing. Isotopic tracing analysis with deuterium(3)-labeled pa …
Deuterium depletion can decrease the expression of C-myc Ha-ras and p53 gene in carcinogen-treated mice.
Gyöngyi Z, Somlyai G. Gyöngyi Z, et al. In Vivo. 2000 May-Jun;14(3):437-9. In Vivo. 2000. PMID: 10904878
The effect of deuterium depletion on gene expression plays a key part in tumour development. ...It is suggested that genes playing a key role in the cell cycle regulation and tumour development are sensitive to deuterium depletion....
The effect of deuterium depletion on gene expression plays a key part in tumour development. ...It is suggested that genes pla …
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.
Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X. Li Y, et al. Cell Metab. 2024 Apr 16:S1550-4131(24)00118-9. doi: 10.1016/j.cmet.2024.03.014. Online ahead of print. Cell Metab. 2024. PMID: 38657612
Utilizing stimulated Raman scattering (SRS) microscopy, we observed significant in situ LD accumulation in microglia of tauopathy mouse brains. SRS imaging, combined with deuterium oxide (D(2)O) labeling, revealed heightened lipogenesis and impaired lipid turnover within L …
Utilizing stimulated Raman scattering (SRS) microscopy, we observed significant in situ LD accumulation in microglia of tauopathy mouse brai …
389 results