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Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery.
Mazet R, García-Otero X, Choisnard L, Wouessidjewe D, Verdoot V, Bossard F, Díaz-Tomé V, Blanc-Marquis V, Otero-Espinar FJ, Fernandez-Ferreiro A, Gèze A. Mazet R, et al. Pharmaceutics. 2020 Jul 30;12(8):717. doi: 10.3390/pharmaceutics12080717. Pharmaceutics. 2020. PMID: 32751583 Free PMC article.
These hydrogels could act as corneal absorption promoters as they allow a higher transcorneal permeation of DXMa through porcine excised cornea, compared to DEXAFREE() and MAXIDEX(). Cytotoxicity assays showed no cytotoxic effects on human primary corneal epithelial cells …
These hydrogels could act as corneal absorption promoters as they allow a higher transcorneal permeation of DXMa through porcine excised cor …
Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs.
Mazet R, Choisnard L, Levilly D, Wouessidjewe D, Gèze A. Mazet R, et al. Pharmaceutics. 2018 Dec 1;10(4):249. doi: 10.3390/pharmaceutics10040249. Pharmaceutics. 2018. PMID: 30513707 Free PMC article.
Finally, in vitro drug release assays from the mixed gels were performed and compared with reference eye drops. Similarly to MAXIDEX() and DEXAFREE(), in the case of mixed gel containing HPbetaCD, more than 90% of the drug was released within 2 h, while in mixed gel contai …
Finally, in vitro drug release assays from the mixed gels were performed and compared with reference eye drops. Similarly to MAXIDEX() and …