Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1979 2
1981 2
1982 3
1983 4
1984 2
1985 2
1986 3
1987 4
1988 7
1989 5
1990 5
1991 15
1992 6
1993 8
1994 10
1995 8
1996 10
1997 10
1998 5
1999 12
2000 3
2001 7
2002 7
2003 9
2004 9
2005 13
2006 10
2007 6
2008 10
2009 6
2010 3
2011 6
2012 7
2013 10
2014 5
2015 4
2016 3
2017 3
2018 5
2019 3
2020 3
2021 8
2022 3
2023 5
2024 4

Text availability

Article attribute

Article type

Publication date

Search Results

258 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for diazepam probes
Your search for diazepam-prodes retrieved no results
Discovering new biology with drug-resistance alleles.
Freedy AM, Liau BB. Freedy AM, et al. Nat Chem Biol. 2021 Dec;17(12):1219-1229. doi: 10.1038/s41589-021-00865-9. Epub 2021 Nov 19. Nat Chem Biol. 2021. PMID: 34799733 Free PMC article. Review.
In this Review, we highlight how resistance mutations have unlocked the potential of small molecule chemical probes to discover new biology. We describe key instances in which resistance mutations and related genetic variants yielded foundational biological insight and cat …
In this Review, we highlight how resistance mutations have unlocked the potential of small molecule chemical probes to discover new b …
Diazepam blocks fear-potentiated startle in humans.
Patrick CJ, Berthot BD, Moore JD. Patrick CJ, et al. J Abnorm Psychol. 1996 Feb;105(1):89-96. doi: 10.1037//0021-843x.105.1.89. J Abnorm Psychol. 1996. PMID: 8666715 Clinical Trial.
The effects of an anxiolytic drug (diazepam) on emotional responses to aversive stimuli were investigated using physiological measures, including the startle probe reflex. Participants were 54 university students assigned to either a placebo group or a 10 mg or 15 m …
The effects of an anxiolytic drug (diazepam) on emotional responses to aversive stimuli were investigated using physiological measure …
Diazepam binding inhibitor peptide: cloning and gene expression.
Mocchetti I, Santi MR. Mocchetti I, et al. Neuropharmacology. 1991 Dec;30(12B):1365-71. doi: 10.1016/s0028-3908(11)80003-1. Neuropharmacology. 1991. PMID: 1780035 Review.
Diazepam binding inhibitor (DBI) is a peptide, initially identified for its ability of displacing the binding of diazepam. The screening of lambda gt 10 cDNA libraries from rat brain with a 47merdeoxyoligonucleotide probe, complementary to a small portion of …
Diazepam binding inhibitor (DBI) is a peptide, initially identified for its ability of displacing the binding of diazepam. The …
Modulation of benzodiazepine binding site sensitivity.
Tallman JF, Gallager DW. Tallman JF, et al. Pharmacol Biochem Behav. 1979 May;10(5):809-13. doi: 10.1016/0091-3057(79)90339-3. Pharmacol Biochem Behav. 1979. PMID: 40255 Review.
Pretreatment of animals with the anticonvulsant, diphenylhydantoin, enhances both diazepam binding and the electrophysiological response to diazepam suggesting one possible locus for the anticonvulsant action of diphenylhydantoin in brain. ...Preliminary results on …
Pretreatment of animals with the anticonvulsant, diphenylhydantoin, enhances both diazepam binding and the electrophysiological respo …
Effect of late pregnancy on salicylate, diazepam, warfarin, and propranolol binding: use of fluorescent probes.
Yoshikawa T, Sugiyama Y, Sawada Y, Iga T, Hanano M, Kawasaki S, Yanagida M. Yoshikawa T, et al. Clin Pharmacol Ther. 1984 Aug;36(2):201-8. doi: 10.1038/clpt.1984.163. Clin Pharmacol Ther. 1984. PMID: 6744779
Unbound fractions of diazepam and salicylate in pregnant women increased but the unbound fraction of warfarin did not change. ...Binding capacities of all probes decreased, which was attributed to decreased serum albumin concentration. ...
Unbound fractions of diazepam and salicylate in pregnant women increased but the unbound fraction of warfarin did not change. ...Bind …
Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.
Zhang P, Zhang W, Liu R, Harris B, Skolnick P, Cook JM. Zhang P, et al. J Med Chem. 1995 May 12;38(10):1679-88. doi: 10.1021/jm00010a013. J Med Chem. 1995. PMID: 7752192
The syntheses of a series of novel imidazobenzodiazepines and their affinities for diazepam sensitive (DS) and diazepam insensitive (DI) GABAA receptors are described. ...
The syntheses of a series of novel imidazobenzodiazepines and their affinities for diazepam sensitive (DS) and diazepam insens …
Rapid synaptic and gamma rhythm signature of mouse critical period plasticity.
Quast KB, Reh RK, Caiati MD, Kopell N, McCarthy MM, Hensch TK. Quast KB, et al. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2123182120. doi: 10.1073/pnas.2123182120. Epub 2023 Jan 4. Proc Natl Acad Sci U S A. 2023. PMID: 36598942 Free PMC article.
Monocular deprivation (MD) acutely induced a transient (<3 h) peak in EEG gamma-power (~40 Hz) specifically within the visual cortex, but only when the critical period was open (juvenile mice or adults after dark-rearing, Lynx1-deletion, or diazepam-rescued GAD65-defici …
Monocular deprivation (MD) acutely induced a transient (<3 h) peak in EEG gamma-power (~40 Hz) specifically within the visual cortex, but …
Photopotentiation of the GABA(A) receptor with caged diazepam.
Sansalone L, Bratsch-Prince J, Tang S, Captain B, Mott DD, Raymo FM. Sansalone L, et al. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21176-21184. doi: 10.1073/pnas.1902383116. Epub 2019 Oct 1. Proc Natl Acad Sci U S A. 2019. PMID: 31575739 Free PMC article.
No caged allosteric modulators of the GABA(A) receptor have been reported so far; to introduce such an investigational approach, we exploited the structural motifs of the benzodiazepinic scaffold to develop a photocaged version of diazepam (CD) that was tested on basolater …
No caged allosteric modulators of the GABA(A) receptor have been reported so far; to introduce such an investigational approach, we exploite …
Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress.
Bollinger JL, Horchar MJ, Wohleb ES. Bollinger JL, et al. Neuropsychopharmacology. 2020 Sep;45(10):1766-1776. doi: 10.1038/s41386-020-0720-1. Epub 2020 May 26. Neuropsychopharmacology. 2020. PMID: 32454511 Free PMC article.
Mice were exposed to chronic unpredictable stress (CUS) or handled intermittently as controls, and received daily injection of vehicle or diazepam (1 mg/kg). As anticipated, diazepam attenuated CUS-induced behavioral despair and cognitive impairments. Further studie …
Mice were exposed to chronic unpredictable stress (CUS) or handled intermittently as controls, and received daily injection of vehicle or …
Cytochrome P450 isozymes and antiepileptic drug interactions.
Levy RH. Levy RH. Epilepsia. 1995;36 Suppl 5:S8-13. doi: 10.1111/j.1528-1157.1995.tb06007.x. Epilepsia. 1995. PMID: 8806399 Review.
The principle of isoform specificity (drugs metabolized by the same isoform should exhibit interactions with the same inhibitors) was applied to the interactions of PHT with 17 inhibitors using two probes for CYP2C9, S-warfarin and tolbutamide. Eleven of 17 interactions (s …
The principle of isoform specificity (drugs metabolized by the same isoform should exhibit interactions with the same inhibitors) was applie …
258 results