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Did you mean dihex (4 results)?
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.
Sun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y. Sun X, et al. Brain Sci. 2021 Nov 11;11(11):1487. doi: 10.3390/brainsci11111487. Brain Sci. 2021. PMID: 34827486 Free PMC article.
We found that the amount of AngIV in mouse tissue increased after the administration of Dihexa compared to that in the WT group. Meanwhile, Dihexa restored spatial learning and cognitive functions in the Morris water maze test. Dihexa increased the neuronal c …
We found that the amount of AngIV in mouse tissue increased after the administration of Dihexa compared to that in the WT group. Mean …
Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.
Weiss JB, Phillips CJ, Malin EW, Gorantla VS, Harding JW, Salgar SK. Weiss JB, et al. Ann Med Surg (Lond). 2021 Oct 8;71:102917. doi: 10.1016/j.amsu.2021.102917. eCollection 2021 Nov. Ann Med Surg (Lond). 2021. PMID: 34703584 Free PMC article.
We investigated whether administration of mesenchymal stem cell (MSC), Granulocyte-Colony Stimulating Factor (G-CSF) and/or Dihexa can improve recovery of limb function following peripheral nerve damage in rat sciatic nerve transection-repair model. ...Bone marrow derived …
We investigated whether administration of mesenchymal stem cell (MSC), Granulocyte-Colony Stimulating Factor (G-CSF) and/or Dihexa ca …
Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.
Uribe PM, Kawas LH, Harding JW, Coffin AB. Uribe PM, et al. Front Cell Neurosci. 2015 Jan 28;9:3. doi: 10.3389/fncel.2015.00003. eCollection 2015. Front Cell Neurosci. 2015. PMID: 25674052 Free PMC article.
Addition of an amino group to the N-terminal of Dihexa also attenuates the protective response, suggesting that even small substitutions greatly alter the specificity of Dihexa for its target. Our data suggest that Dihexa confers protection of hair cells thro …
Addition of an amino group to the N-terminal of Dihexa also attenuates the protective response, suggesting that even small substituti …
The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease.
Wright JW, Harding JW. Wright JW, et al. J Alzheimers Dis. 2015;45(4):985-1000. doi: 10.3233/JAD-142814. J Alzheimers Dis. 2015. PMID: 25649658 Review.
This growth factor system has recently been shown to induce dendritic arborization and synaptogenesis when stimulated by a newly developed angiotensin-based analogue, N-hexanoic-Tyr-Ile-(6) amino hexanoic amide (Dihexa). This small molecule was derived from the pre-prototy …
This growth factor system has recently been shown to induce dendritic arborization and synaptogenesis when stimulated by a newly developed a …
The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases.
Wright JW, Kawas LH, Harding JW. Wright JW, et al. Prog Neurobiol. 2015 Feb;125:26-46. doi: 10.1016/j.pneurobio.2014.11.004. Epub 2014 Nov 29. Prog Neurobiol. 2015. PMID: 25455861 Review.
These research efforts are described along with details concerning a recently synthesized molecule, Dihexa that shows promise in overcoming memory and motor dysfunctions by augmenting synaptic connectivity via the formation of new functional synapses....
These research efforts are described along with details concerning a recently synthesized molecule, Dihexa that shows promise in over …
Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity.
Bapst JP, Froidevaux S, Calame M, Tanner H, Eberle AN. Bapst JP, et al. J Recept Signal Transduct Res. 2007;27(5-6):383-409. doi: 10.1080/10799890701723528. J Recept Signal Transduct Res. 2007. PMID: 18097939
In vitro, all three peptides were more potent ligands of the mouse B16-F1 melanoma cell melanocortin-1 receptor (MC1-R) than DOTA-NAPamide, which served as standard. The binding activity of DOTA-diHexa(NC-NC)-amide was 1.75-fold higher, that of diHexa(NC-NC)-Gly-Lys …
In vitro, all three peptides were more potent ligands of the mouse B16-F1 melanoma cell melanocortin-1 receptor (MC1-R) than DOTA-NAPamide, …
Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells.
Mathapati S, Siller R, Impellizzeri AA, Lycke M, Vegheim K, Almaas R, Sullivan GJ. Mathapati S, et al. Curr Protoc Stem Cell Biol. 2016 Aug 17;38:1G.6.1-1G.6.18. doi: 10.1002/cpsc.13. Curr Protoc Stem Cell Biol. 2016. PMID: 27532814
The resulting hepatoblasts are then differentiated to HLCs with N-hexanoic-Tyr, Ile-6 aminohexanoic amide (Dihexa, a hepatocyte growth factor agonist) and dexamethasone. ...
The resulting hepatoblasts are then differentiated to HLCs with N-hexanoic-Tyr, Ile-6 aminohexanoic …
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.
Benoist CC, Kawas LH, Zhu M, Tyson KA, Stillmaker L, Appleyard SM, Wright JW, Wayman GA, Harding JW. Benoist CC, et al. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402. doi: 10.1124/jpet.114.218735. Epub 2014 Sep 3. J Pharmacol Exp Ther. 2014. PMID: 25187433 Free PMC article.
Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle(1)-AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-d …
Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent com …
Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.
Pan T, Wang N, Zhang J, Yang F, Chen Y, Zhuang Y, Xu Y, Fang J, You K, Lin X, Li Y, Li S, Liang K, Li YX, Gao Y. Pan T, et al. Stem Cell Res Ther. 2022 Apr 11;13(1):159. doi: 10.1186/s13287-022-02831-1. Stem Cell Res Ther. 2022. PMID: 35410439 Free PMC article.
RESULTS: We demonstrated that small-molecule cocktail CIP (including CHIR99021, IDE1, and PD0332991) efficiently induced definitive endoderm (DE) formation via increased endogenous TGF-beta/Nodal signaling. Furthermore, we identified that combining Vitamin C, Dihexa, and F …
RESULTS: We demonstrated that small-molecule cocktail CIP (including CHIR99021, IDE1, and PD0332991) efficiently induced definitive endoderm …
Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.
McCoy AT, Benoist CC, Wright JW, Kawas LH, Bule-Ghogare JM, Zhu M, Appleyard SM, Wayman GA, Harding JW. McCoy AT, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):141-54. doi: 10.1124/jpet.112.199497. Epub 2012 Oct 10. J Pharmacol Exp Ther. 2013. PMID: 23055539 Free PMC article.
Subsequent chemical modifications, which were designed to increase hydrophobicity and decrease hydrogen bonding, yielded an orally active, blood-barrier permeant, metabolically stabilized analog, N-hexanoic-Tyr-Ile-(6) aminohexanoic am …
Subsequent chemical modifications, which were designed to increase hydrophobicity and decrease hydrogen bonding, yielded an orally active, b …
17 results