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Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial.
Moon JM, Ratliff KM, Hagele AM, Stecker RA, Mumford PW, Kerksick CM. Moon JM, et al. Nutrients. 2021 Dec 28;14(1):124. doi: 10.3390/nu14010124. Nutrients. 2021. PMID: 35010998 Free PMC article. Clinical Trial.
Berberine is a natural alkaloid used to improve glycemia but displays poor bioavailability and increased rates of gastrointestinal distress at higher doses. Recently, dihydroberberine has been developed to combat these challenges. This study was designed to determine the r …
Berberine is a natural alkaloid used to improve glycemia but displays poor bioavailability and increased rates of gastrointestinal distress …
Toxicological assessment of dihydroberberine.
Lewis KD, Falk M. Lewis KD, et al. Food Chem Toxicol. 2022 Oct;168:113301. doi: 10.1016/j.fct.2022.113301. Epub 2022 Jul 19. Food Chem Toxicol. 2022. PMID: 35868606
A battery of studies was conducted to examine the toxicological potential of dihydroberberine (DHBBR), a derivative of berberine (BBR). The genotoxicity studies conducted on DHBBR, including the bacterial reverse mutation test, the mouse lymphoma assay, and the in vivo mic …
A battery of studies was conducted to examine the toxicological potential of dihydroberberine (DHBBR), a derivative of berberine (BBR …
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.
Ma SR, Tong Q, Lin Y, Pan LB, Fu J, Peng R, Zhang XF, Zhao ZX, Li Y, Yu JB, Cong L, Han P, Zhang ZW, Yu H, Wang Y, Jiang JD. Ma SR, et al. Signal Transduct Target Ther. 2022 Jul 7;7(1):207. doi: 10.1038/s41392-022-01027-6. Signal Transduct Target Ther. 2022. PMID: 35794102 Free PMC article.
We found that oral BBR in animals lowers TMAO biosynthesis in intestine through interacting with the enzyme/co-enzyme of choline-trimethylamine lyase (CutC) and flavin-containing monooxygenase (FMO) in the gut microbiota. This action was performed by BBR's metabolite dihydrobe …
We found that oral BBR in animals lowers TMAO biosynthesis in intestine through interacting with the enzyme/co-enzyme of choline-trimethylam …
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota.
Wang Y, Tong Q, Ma SR, Zhao ZX, Pan LB, Cong L, Han P, Peng R, Yu H, Lin Y, Gao TL, Shou JW, Li XY, Zhang XF, Zhang ZW, Fu J, Wen BY, Yu JB, Cao X, Jiang JD. Wang Y, et al. Signal Transduct Target Ther. 2021 Feb 24;6(1):77. doi: 10.1038/s41392-020-00456-5. Signal Transduct Target Ther. 2021. PMID: 33623004 Free PMC article.
Here, we show that oral berberine (BBR) might supply H() through dihydroberberine (reduced BBR produced by bacterial nitroreductase) and promote the production of BH(4) from dihydrobiopterin; the increased BH(4) enhances TH activity, which accelerates the production of L-d …
Here, we show that oral berberine (BBR) might supply H() through dihydroberberine (reduced BBR produced by bacterial nitroreductase) …
Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice.
Li C, Dong N, Wu B, Mo Z, Xie J, Lu Q. Li C, et al. Phytomedicine. 2021 Sep;90:153631. doi: 10.1016/j.phymed.2021.153631. Epub 2021 Jun 25. Phytomedicine. 2021. PMID: 34253428
BACKGROUND: As a chronic inflammatory disease, ulcerative colitis (UC) is relevant to a rising risk of colorectal cancer. Dihydroberberine (DHBB), a natural occurring isoquinoline alkaloid with various bioactivities, was found in many plants including Coptis chinensis Fran …
BACKGROUND: As a chronic inflammatory disease, ulcerative colitis (UC) is relevant to a rising risk of colorectal cancer. Dihydroberberin …
Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-kappaB and MAPK signaling pathways.
Tan L, Wang Y, Ai G, Luo C, Chen H, Li C, Zeng H, Xie J, Chen J, Su Z. Tan L, et al. Int Immunopharmacol. 2019 Oct;75:105802. doi: 10.1016/j.intimp.2019.105802. Epub 2019 Aug 8. Int Immunopharmacol. 2019. PMID: 31401380
Dihydroberberine (DHB), a hydrogenated derivative of berberine (BBR), has been firstly identified in Phellodendri Chinese Cortex (PC) by HPLC-ESI-MS/MS. ...
Dihydroberberine (DHB), a hydrogenated derivative of berberine (BBR), has been firstly identified in Phellodendri Chinese Cortex (PC) …
Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators.
Dai B, Ma Y, Wang W, Zhan Y, Zhang D, Liu R, Zhang Y. Dai B, et al. J Cell Mol Med. 2017 Oct;21(10):2573-2585. doi: 10.1111/jcmm.13178. Epub 2017 Apr 26. J Cell Mol Med. 2017. PMID: 28444871 Free PMC article.
Combination chemotherapy is a good strategy in cancer therapy. We evaluated the antitumour effects of dihydroberberine combined with sunitinib (DCS) on the human non-small cell lung cancer cell lines (NSCLC), A549, NCI-H460, and NCI-H1299 in vitro and in vivo. DCS showed s …
Combination chemotherapy is a good strategy in cancer therapy. We evaluated the antitumour effects of dihydroberberine combined with …
Synthesis of new dihydroberberine and tetrahydroberberine analogues and evaluation of their antiproliferative activity on NCI-H1975 cells.
Mari G, De Crescentini L, Benedetti S, Palma F, Santeusanio S, Mantellini F. Mari G, et al. Beilstein J Org Chem. 2020 Jul 6;16:1606-1616. doi: 10.3762/bjoc.16.133. eCollection 2020. Beilstein J Org Chem. 2020. PMID: 32704327 Free PMC article.
Dihydroberberine (DHBER), the partially reduced form of the alkaloid berberine (BER), is known to exhibit important biological activities. ...
Dihydroberberine (DHBER), the partially reduced form of the alkaloid berberine (BER), is known to exhibit important biological activi …
Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.
Xu L, Lin G, Yu Q, Li Q, Mai L, Cheng J, Xie J, Liu Y, Su Z, Li Y. Xu L, et al. Front Pharmacol. 2021 Apr 20;12:645879. doi: 10.3389/fphar.2021.645879. eCollection 2021. Front Pharmacol. 2021. PMID: 33959014 Free PMC article.
Berberine (BBR), its characteristic ingredient, has also been shown to be effective in alleviating monosodium urate crystals-triggered gout inflammation in vitro and in vivo. Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved in vivo efficacy o …
Berberine (BBR), its characteristic ingredient, has also been shown to be effective in alleviating monosodium urate crystals-triggered gout …
46 results