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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1955 1
1967 2
1968 1
1969 2
1970 4
1971 1
1972 3
1973 2
1974 3
1975 3
1976 3
1977 7
1978 6
1979 2
1980 5
1981 7
1982 8
1983 9
1984 10
1985 8
1986 8
1987 4
1988 9
1989 3
1990 4
1991 2
1992 16
1995 2
1996 4
1997 3
1998 1
1999 4
2000 1
2001 3
2002 1
2003 3
2005 1
2007 1
2008 2
2009 1
2010 2
2011 1
2012 1
2014 2
2015 3
2017 2
2018 2
2019 1
2020 5
2021 4
2022 2
2023 1
2024 6

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187 results

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Page 1
[Dihydroergocristine. A review of pharmacology and toxicology].
Coppi G. Coppi G. Arzneimittelforschung. 1992 Nov;42(11A):1381-90. Arzneimittelforschung. 1992. PMID: 1492857 Review. German.
A pharmacological and toxicological review of dihydroergocristine (DHEC, CAS 17479-19-5) is reported. Dihydroergocristine exercises a double agonistic/antagonistic activity on dopaminergic and adrenergic receptors; it also shows a non competitive antagonistic effect …
A pharmacological and toxicological review of dihydroergocristine (DHEC, CAS 17479-19-5) is reported. Dihydroergocristine exer …
The effect of topical dihydroergocristine on the intraocular pressure in alpha-chymotrypsin-induced ocular hypertensive rabbits.
Melena J, Santafé J, Segarra J. Melena J, et al. Methods Find Exp Clin Pharmacol. 1998 Dec;20(10):861-7. doi: 10.1358/mf.1998.20.10.487542. Methods Find Exp Clin Pharmacol. 1998. PMID: 10091223 Free article.
Intraocular pressure responses to drug vehicle and 5 different doses of topical dihydroergocristine were studied in order to obtain a dose-response curve. ...Our findings suggest that topical dihydroergocristine may be useful in the treatment of ocular hypertension. …
Intraocular pressure responses to drug vehicle and 5 different doses of topical dihydroergocristine were studied in order to obtain a …
[Cerebral actions of dihydroergocristine].
Drago F, Valerio C, Nardo L, Genazzani AA, D'Agata V, Mauceri F, Freni V. Drago F, et al. Arzneimittelforschung. 1992 Nov;42(11A):1391-4. Arzneimittelforschung. 1992. PMID: 1492858 Review. German.
Dihydroergocristine (DEC, CAS 17479-19-5) is a dihydrogenated ergot alkaloid with a potent dopaminergic activity that has been proved both in vitro and in vivo. ...
Dihydroergocristine (DEC, CAS 17479-19-5) is a dihydrogenated ergot alkaloid with a potent dopaminergic activity that has been proved …
Dihydroergocristine in stopping lactation: double-blind study vs bromocriptine.
de Aloysio D, Pamparana F, Zanotti A, Fabiani AG, Bottiglioni F. de Aloysio D, et al. Gynecol Endocrinol. 1988 Mar;2(1):67-71. doi: 10.3109/09513598809029341. Gynecol Endocrinol. 1988. PMID: 3140592 Clinical Trial.
After 5 days milk secretion was reduced more significantly in the dihydroergocristine group; after 10 days of treatment 6 cases treated with bromocriptine and 1 case treated with dihydroergocristine still revealed a low milk secretion. ...Other symptoms, such as nau …
After 5 days milk secretion was reduced more significantly in the dihydroergocristine group; after 10 days of treatment 6 cases treat …
Dihydroergocristine and memory alterations of aged male rats.
Drago F, Valerio C, Scalisi B, D'Agata V, Scapagnini U. Drago F, et al. Pharmacol Biochem Behav. 1988 Aug;30(4):961-5. doi: 10.1016/0091-3057(88)90127-x. Pharmacol Biochem Behav. 1988. PMID: 3147464
The ergot alkaloid derivative dihydroergocristine (DHECS) was injected acutely or subchronically to aged male rats of the Sprague-Dawley strain, 26 months old, at the dose of 0.05 or 0.1 mg/kg. ...
The ergot alkaloid derivative dihydroergocristine (DHECS) was injected acutely or subchronically to aged male rats of the Sprague-Daw …
The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides.
Lei X, Yu J, Niu Q, Liu J, Fraering PC, Wu F. Lei X, et al. Sci Rep. 2015 Nov 16;5:16541. doi: 10.1038/srep16541. Sci Rep. 2015. PMID: 26567970 Free PMC article.
To search for bioactive molecules that can reduce the amount of amyloid-beta peptides (Abeta) and that have better pharmacokinetics and an improved safety profile, we completed a screen of ~400 natural products by using cell-based and cell-free gamma-secretase activity assays. We …
To search for bioactive molecules that can reduce the amount of amyloid-beta peptides (Abeta) and that have better pharmacokinetics and an i …
In Vitro Effect and Mechanism of Action of Ergot Alkaloid Dihydroergocristine in Chemoresistant Prostate Cancer Cells.
Bai L, Li X, Ma X, Zhao R, Wu D. Bai L, et al. Anticancer Res. 2020 Nov;40(11):6051-6062. doi: 10.21873/anticanres.14626. Anticancer Res. 2020. PMID: 33109543
We evaluated the in vitro activity and mechanism of action of dihydroergocristine (DHECS), an ergot alkaloid approved for the treatment of dementia, in PCa cells. ...
We evaluated the in vitro activity and mechanism of action of dihydroergocristine (DHECS), an ergot alkaloid approved for the treatme …
Pharmacokinetics of dihydroergocristine and its major metabolite 8'-hydroxy-dihydroergocristine in human plasma.
Bicalho B, Guzzo GC, Lilla S, Dos Santos HO, Mendes GD, Caliendo G, Perissutti E, Aiello A, Luciano P, Santagada V, Pereira AS, De Nucci G. Bicalho B, et al. Curr Drug Metab. 2005 Dec;6(6):519-29. doi: 10.2174/138920005774832669. Curr Drug Metab. 2005. PMID: 16379666
Dihydroergocristine (DHEC) is a semi-synthetic drug mainly used for age-related cognitive impairment. In this study, its major metabolite 8'-hydroxy-dihydroergocristine (8'-OH-DHEC) was produced in incubates of a bovine liver preparation using dihydroergocristine …
Dihydroergocristine (DHEC) is a semi-synthetic drug mainly used for age-related cognitive impairment. In this study, its major metabo …
Dihydroergocristine-induced stimulation of the 5-HT autoreceptor in the hypothalamus of the rat.
Moret C, Briley M. Moret C, et al. Neuropharmacology. 1986 Feb;25(2):169-74. doi: 10.1016/0028-3908(86)90038-9. Neuropharmacology. 1986. PMID: 3010160
In slices of the hypothalamus of the rat, prelabelled with [3H]5-hydroxytryptamine ([3H]5-HT), dihydroergocristine (DHEC) decreased in a concentration-dependent manner (0.01-1 microM) the release of [3H]transmitter elicited by stimulation. ...
In slices of the hypothalamus of the rat, prelabelled with [3H]5-hydroxytryptamine ([3H]5-HT), dihydroergocristine (DHEC) decreased i …
187 results