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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 2
1962 5
1963 1
1964 10
1965 15
1966 23
1967 29
1968 68
1969 60
1970 81
1971 175
1972 305
1973 309
1974 365
1975 515
1976 426
1977 449
1978 503
1979 548
1980 619
1981 646
1982 774
1983 709
1984 858
1985 956
1986 866
1987 883
1988 929
1989 1031
1990 963
1991 1073
1992 1057
1993 1195
1994 1422
1995 1442
1996 1747
1997 1751
1998 1876
1999 2105
2000 2392
2001 2592
2002 2706
2003 2937
2004 3185
2005 3421
2006 3660
2007 3763
2008 3819
2009 4108
2010 4525
2011 4715
2012 5020
2013 5130
2014 5397
2015 5403
2016 5477
2017 5543
2018 5609
2019 5791
2020 6548
2021 7034
2022 6533
2023 6143
2024 2711
2025 1

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129,752 results

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Page 1
Mechanisms of DNA damage, repair, and mutagenesis.
Chatterjee N, Walker GC. Chatterjee N, et al. Environ Mol Mutagen. 2017 Jun;58(5):235-263. doi: 10.1002/em.22087. Epub 2017 May 9. Environ Mol Mutagen. 2017. PMID: 28485537 Free PMC article. Review.
However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. Deviations in this fine-tuning are known to destabilize cellular metabolic homeostasis, as exemplifie …
However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the …
Non-homologous DNA end joining and alternative pathways to double-strand break repair.
Chang HHY, Pannunzio NR, Adachi N, Lieber MR. Chang HHY, et al. Nat Rev Mol Cell Biol. 2017 Aug;18(8):495-506. doi: 10.1038/nrm.2017.48. Epub 2017 May 17. Nat Rev Mol Cell Biol. 2017. PMID: 28512351 Free PMC article. Review.
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. ...In this Review, we discuss the most recent findings regarding the relative involvement of the different NHEJ proteins in th …
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromos …
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.
Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S. Sancar A, et al. Annu Rev Biochem. 2004;73:39-85. doi: 10.1146/annurev.biochem.73.011303.073723. Annu Rev Biochem. 2004. PMID: 15189136 Review.
DNA repair mechanisms include direct repair, base excision repair, nucleotide excision repair, double-strand break repair, and cross-link repair. ...In this review the molecular mechanisms of DNA repair and the DNA …
DNA repair mechanisms include direct repair, base excision repair, nucleotide excision repair, double-str …
Biomarker-Guided Development of DNA Repair Inhibitors.
Cleary JM, Aguirre AJ, Shapiro GI, D'Andrea AD. Cleary JM, et al. Mol Cell. 2020 Jun 18;78(6):1070-1085. doi: 10.1016/j.molcel.2020.04.035. Epub 2020 May 26. Mol Cell. 2020. PMID: 32459988 Free PMC article. Review.
Recent work has identified additional genomic and functional assays of DNA repair that provide new predictive and pharmacodynamic biomarkers for these targeted therapies. Here, we examine the development of selective agents targeting DNA repair, includ …
Recent work has identified additional genomic and functional assays of DNA repair that provide new predictive and pharmacodyna …
DNA Repair: Translation to the Clinic.
Minten EV, Yu DS. Minten EV, et al. Clin Oncol (R Coll Radiol). 2019 May;31(5):303-310. doi: 10.1016/j.clon.2019.02.007. Epub 2019 Mar 12. Clin Oncol (R Coll Radiol). 2019. PMID: 30876709 Free PMC article. Review.
Therefore, it is critically important for a cell to have the capacity to properly respond to and repair DNA damage as it occurs. The DNA damage response (DDR) describes a collection of DNA repair pathways that aid in the protection of genomic in …
Therefore, it is critically important for a cell to have the capacity to properly respond to and repair DNA damage as it occur …
DNA helicases in homologous recombination repair.
Branzei D, Szakal B. Branzei D, et al. Curr Opin Genet Dev. 2021 Dec;71:27-33. doi: 10.1016/j.gde.2021.06.009. Epub 2021 Jul 14. Curr Opin Genet Dev. 2021. PMID: 34271541 Review.
Helicases are in the spotlight of DNA metabolism and are critical for DNA repair in all domains of life. At their biochemical core, they bind and hydrolyze ATP, converting this energy to translocate unidirectionally, with different strand polarities and subst …
Helicases are in the spotlight of DNA metabolism and are critical for DNA repair in all domains of life. At their bioch …
Transcription-coupled DNA double-strand break repair.
Guha S, Bhaumik SR. Guha S, et al. DNA Repair (Amst). 2022 Jan;109:103211. doi: 10.1016/j.dnarep.2021.103211. Epub 2021 Aug 13. DNA Repair (Amst). 2022. PMID: 34883263 Review.
Fortunately, the cell is armed to safeguard its genome by various mechanisms such as nucleotide excision, base excision, mismatch and DNA double-strand break repairs. While these processes maintain the integrity of the genome throughout, DNA repair occurs pre …
Fortunately, the cell is armed to safeguard its genome by various mechanisms such as nucleotide excision, base excision, mismatch and DNA …
DNA repair as a human biomonitoring tool: Comet assay approaches.
Azqueta A, Langie SAS, Boutet-Robinet E, Duthie S, Ladeira C, Møller P, Collins AR, Godschalk RWL; Working Group 5 of the hCOMET project (CA15132). Azqueta A, et al. Mutat Res Rev Mutat Res. 2019 Jul-Sep;781:71-87. doi: 10.1016/j.mrrev.2019.03.002. Epub 2019 Mar 6. Mutat Res Rev Mutat Res. 2019. PMID: 31416580 Review.
These conditions include i) robustness of the assay, ii) sources of inter- and intra-individual variability must be known, iii) DNA repair kinetics should be assessed to optimize sampling timing; and iv) DNA repair in accessible surrogate tissues shoul …
These conditions include i) robustness of the assay, ii) sources of inter- and intra-individual variability must be known, iii) DNA …
Balancing DNA repair to prevent ageing and cancer.
Stead ER, Bjedov I. Stead ER, et al. Exp Cell Res. 2021 Aug 15;405(2):112679. doi: 10.1016/j.yexcr.2021.112679. Epub 2021 Jun 5. Exp Cell Res. 2021. PMID: 34102225 Free PMC article. Review.
Loss of efficient DNA damage repair can lead to accelerated ageing phenotypes or an increased cancer risk, and the trade-off between cancer susceptibility and longevity is often driven by the cell's response to DNA damage. High levels of mutations in DNA …
Loss of efficient DNA damage repair can lead to accelerated ageing phenotypes or an increased cancer risk, and the trade-off b …
DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy.
Peng Y, Pei H. Peng Y, et al. J Zhejiang Univ Sci B. 2021 Jan 15;22(1):47-62. doi: 10.1631/jzus.B2000344. J Zhejiang Univ Sci B. 2021. PMID: 33448187 Free PMC article. Review.
Alkylated DNA lesions, induced by both exogenous chemical agents and endogenous metabolites, represent a major form of DNA damage in cells. ...However, maintaining a proper balance between these pathways is crucial for the favorable response of an organism to alkyla …
Alkylated DNA lesions, induced by both exogenous chemical agents and endogenous metabolites, represent a major form of DNA dam …
129,752 results
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