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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 2
1990 1
1992 1
1993 1
1995 1
2000 1
2002 1
2003 1
2008 1
2010 3
2011 2
2014 2
2015 1
2017 1
2018 3
2019 1
2020 1
2021 1
2024 0

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25 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Impact of doxofylline in COPD: A pairwise meta-analysis.
Cazzola M, Calzetta L, Rogliani P, Page C, Matera MG. Cazzola M, et al. Pulm Pharmacol Ther. 2018 Aug;51:1-9. doi: 10.1016/j.pupt.2018.04.010. Epub 2018 Apr 26. Pulm Pharmacol Ther. 2018. PMID: 29705620 Free article. Review.

The total administered dose of doxofylline significantly (P < 0.001) interacted with the size of the effect estimates detected for FEV(1). ...Doxofylline is an effective and safe medicine when administered to patients with COPD and can be considered as an alterna

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The total administered dose of doxofylline significantly (P < 0.001) interacted with the size of the effect estimates detected for

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Impact of doxofylline compared to theophylline in asthma: A pooled analysis of functional and clinical outcomes from two multicentre, double-blind, randomized studies (DOROTHEO 1 and DOROTHEO 2).
Calzetta L, Hanania NA, Dini FL, Goldstein MF, Fairweather WR, Howard WW, Cazzola M. Calzetta L, et al. Pulm Pharmacol Ther. 2018 Dec;53:20-26. doi: 10.1016/j.pupt.2018.09.007. Epub 2018 Sep 13. Pulm Pharmacol Ther. 2018. PMID: 30219705 Free article.
Asthmatic patients 16 years of age with forced expiratory volume in 1 s (FEV(1)) 50% and <80% and with 15% post-bronchodilator increase in FEV(1) were randomized in a 1:1:1:1 ratio in DOROTHEO 1 to receive doxofylline 200 mg, doxofylline 400 mg, theophylline 250 …
Asthmatic patients 16 years of age with forced expiratory volume in 1 s (FEV(1)) 50% and <80% and with 15% post-bronchodilator increase i …
A long-term clinical trial on the efficacy and safety profile of doxofylline in Asthma: The LESDA study.
Calzetta L, Matera MG, Goldstein MF, Fairweather WR, Howard WW, Cazzola M, Rogliani P. Calzetta L, et al. Pulm Pharmacol Ther. 2020 Feb;60:101883. doi: 10.1016/j.pupt.2019.101883. Epub 2019 Dec 26. Pulm Pharmacol Ther. 2020. PMID: 31884206 Free article. Clinical Trial.
Doxofylline, an oral methylxanthine with bronchodilator and anti-inflammatory activities, offers a promising alternative to theophylline due to its superior efficacy/safety profile. No long-term studies on the efficacy and safety of doxofylline are currently availab …
Doxofylline, an oral methylxanthine with bronchodilator and anti-inflammatory activities, offers a promising alternative to theophyll …
Efficacy and safety of combined doxofylline and salbutamol in treatment of acute exacerbation of chronic obstructive pulmonary disease.
Du X, Bao H, Zhao D. Du X, et al. Rev Assoc Med Bras (1992). 2021 Sep;67(9):1256-1260. doi: 10.1590/1806-9282.20210429. Rev Assoc Med Bras (1992). 2021. PMID: 34816917 Free article. Clinical Trial.
OBJECTIVE: The aim of this study was to investigate the efficacy and safety of combined doxofylline and salbutamol in the treatment of acute exacerbation of chronic obstructive pulmonary disease. METHODS: A total of 68 acute exacerbation of chronic obstructive pulmonary di …
OBJECTIVE: The aim of this study was to investigate the efficacy and safety of combined doxofylline and salbutamol in the treatment o …
Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial.
Rajanandh MG, Nageswari AD, Ilango K. Rajanandh MG, et al. Clin Ther. 2015 Feb 1;37(2):418-26. doi: 10.1016/j.clinthera.2014.12.008. Epub 2015 Jan 8. Clin Ther. 2015. PMID: 25577543 Clinical Trial.
This study aimed to compare the efficacy and safety of montelukast, doxofylline, and tiotropium with a low-dose budesonide in patients with mild to moderate persistent asthma. ...IMPLICATIONS: Among the tested second-line treatment regimens, the budesonide/montelukast comb …
This study aimed to compare the efficacy and safety of montelukast, doxofylline, and tiotropium with a low-dose budesonide in patient …
Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma -- a double-blind randomized placebo-controlled multicentre clinical trial.
Goldstein MF, Chervinsky P. Goldstein MF, et al. Med Sci Monit. 2002 Apr;8(4):CR297-304. Med Sci Monit. 2002. PMID: 11951074 Clinical Trial.
MATERIAL/METHODS: Three hundred forty-six patients were randomly assigned to a 12-week oral treatment with either doxofylline 400 mg t.i.d. (high dose), doxofylline 200 mg t.i.d. (low dose), theophylline 250 mg t.i.d. ...Asthma attack rate and use of albuterol decre …
MATERIAL/METHODS: Three hundred forty-six patients were randomly assigned to a 12-week oral treatment with either doxofylline 400 mg …
Treatment of reversible chronic airways obstruction with doxofylline compared with slow-release theophylline: a double-blind, randomized, multicentre trial.
Melillo G, Balzano G, Jodice F, De Felice A, Campisi V, Capone M, Di Filippo A, Foddai G, Franzone JS, Grossi E, et al. Melillo G, et al. Int J Clin Pharmacol Res. 1989;9(6):397-405. Int J Clin Pharmacol Res. 1989. PMID: 2699466 Clinical Trial.
The two groups of 69 patients on doxofylline and 70 patients on theophylline did not differ in their baseline clinical and functional parameters. ...Both drugs significantly increased spirometric parameters (p less than 0.001 for all tests) and significantly reduced salbut …
The two groups of 69 patients on doxofylline and 70 patients on theophylline did not differ in their baseline clinical and functional …
Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease.
Wang T, Luo G, Hu Y, Li F, Ma J, Wang J, Zuo P, Xiong W, Liu X, Zhao J, Xiong S, Zhang Z, Li C, Zhao S, Sun J, Xu Y. Wang T, et al. J Huazhong Univ Sci Technolog Med Sci. 2011 Oct;31(5):614. doi: 10.1007/s11596-011-0570-5. Epub 2011 Oct 25. J Huazhong Univ Sci Technolog Med Sci. 2011. PMID: 22038349 Clinical Trial.
This study compared the efficacy and safety of tiotropium bromide inhalation powder (spiriva) and doxofylline oral tablet (doxofylline) in the treatment of chronic obstructive pulmonary disease (COPD). ...We are led to conclude that both tiotropium at 18 mug a day a …
This study compared the efficacy and safety of tiotropium bromide inhalation powder (spiriva) and doxofylline oral tablet (doxofyl …
Comparison of intravenously administered doxofylline and placebo for the treatment of severe acute airways obstruction.
Dolcetti A, Osella D, De Filippis G, Carnuccio C, Grossi E. Dolcetti A, et al. J Int Med Res. 1988 Jul-Aug;16(4):264-9. doi: 10.1177/030006058801600403. J Int Med Res. 1988. PMID: 3169372 Clinical Trial.
This double-blind, randomized, placebo-controlled study investigated the therapeutic effects of a single dose of doxofylline, a methylxanthine derivative, in 10 patients aged 26-79 years. ...Clinical tolerability of doxofylline proved to be good since no signs of lo …
This double-blind, randomized, placebo-controlled study investigated the therapeutic effects of a single dose of doxofylline, a methy …
The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients.
Lazzaroni M, Grossi E, Bianchi Porro G. Lazzaroni M, et al. Aliment Pharmacol Ther. 1990 Dec;4(6):643-9. doi: 10.1111/j.1365-2036.1990.tb00512.x. Aliment Pharmacol Ther. 1990. PMID: 2129651 Clinical Trial.
In a 1-hour infusion, six patients received either 240 mg aminophylline i.v. or 200 mg doxofylline i.v., and six received either 240 mg aminophylline i.v. or 400 mg doxofylline i.v. ...These findings suggest that doxofylline, unlike aminophylline, has a low s …
In a 1-hour infusion, six patients received either 240 mg aminophylline i.v. or 200 mg doxofylline i.v., and six received either 240 …
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