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Showing results for doxorubicin hcl kp
Your search for doxorubicine-hcl-kp retrieved no results
Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma.
Castellino SM, Pei Q, Parsons SK, Hodgson D, McCarten K, Horton T, Cho S, Wu Y, Punnett A, Dave H, Henderson TO, Hoppe BS, Charpentier AM, Keller FG, Kelly KM. Castellino SM, et al. N Engl J Med. 2022 Nov 3;387(18):1649-1660. doi: 10.1056/NEJMoa2206660. N Engl J Med. 2022. PMID: 36322844 Free PMC article. Clinical Trial.
Patients were assigned to receive five 21-day cycles of brentuximab vedotin with doxorubicin, vincristine, etoposide, prednisone, and cyclophosphamide (brentuximab vedotin group) or the standard pediatric regimen of doxorubicin, bleomycin, vincristine, etoposide, pr …
Patients were assigned to receive five 21-day cycles of brentuximab vedotin with doxorubicin, vincristine, etoposide, prednisone, and …
Doxorubicin Detoxification in Healthy Organs Improves Tolerability to High Drug Doses for Enhanced Antitumor Therapy.
Jiang Q, Chen M, Yang X, Zhuge D, Yin Q, Tian D, Li L, Zhang X, Xu W, Liu S, Li F, Weng C, Lin Y, Wang H, Rao D, Chen Y, Cai Q, Yan L, Wang L, Wang F, Lu X, Wen B, Zhao Y, Zhang F, Xia W, Zhu H, Chen Y. Jiang Q, et al. ACS Nano. 2023 Apr 25;17(8):7705-7720. doi: 10.1021/acsnano.3c00195. Epub 2023 Apr 6. ACS Nano. 2023. PMID: 37022161
With its well-documented toxicity, the use of doxorubicin (Dox) for cancer treatment requires trade-offs between safety and effectiveness. ...By localizing treatment to organs susceptible to Dox-mediated toxicity, BPN-KP acts as a decoy that prevents the drug from i …
With its well-documented toxicity, the use of doxorubicin (Dox) for cancer treatment requires trade-offs between safety and effective …
Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial.
Tap WD, Wagner AJ, Schöffski P, Martin-Broto J, Krarup-Hansen A, Ganjoo KN, Yen CC, Abdul Razak AR, Spira A, Kawai A, Le Cesne A, Van Tine BA, Naito Y, Park SH, Fedenko A, Pápai Z, Soldatenkova V, Shahir A, Mo G, Wright J, Jones RL; ANNOUNCE Investigators. Tap WD, et al. JAMA. 2020 Apr 7;323(13):1266-1276. doi: 10.1001/jama.2020.1707. JAMA. 2020. PMID: 32259228 Free PMC article. Clinical Trial.
In a phase 2 study, an overall survival benefit in this population was observed with the addition of olaratumab to doxorubicin over doxorubicin alone. OBJECTIVE: To determine the efficacy of doxorubicin plus olaratumab in patients with advanced/metastatic STS …
In a phase 2 study, an overall survival benefit in this population was observed with the addition of olaratumab to doxorubicin over …
Rifampicin efficacy against doxorubicin-induced cardiotoxicity in mice.
Basal OA, Zahran RF, Saad EA. Basal OA, et al. Egypt Heart J. 2023 Aug 21;75(1):73. doi: 10.1186/s43044-023-00403-z. Egypt Heart J. 2023. PMID: 37603165 Free PMC article.
BACKGROUND: The toxic effect of doxorubicin on the heart limits its clinical usage in cancer therapy. This work intended to investigate, for the first time, the efficacy of rifampicin administration against doxorubicin-induction of cardiotoxicity in mice. Forty adul …
BACKGROUND: The toxic effect of doxorubicin on the heart limits its clinical usage in cancer therapy. This work intended to investiga …
Doxorubicin induced cardio toxicity through sirtuins mediated mitochondrial disruption.
Ahmad N, Ullah A, Chu P, Tian W, Tang Z, Sun Z. Ahmad N, et al. Chem Biol Interact. 2022 Sep 25;365:110028. doi: 10.1016/j.cbi.2022.110028. Epub 2022 Jul 31. Chem Biol Interact. 2022. PMID: 35921947 Review.
The chemotherapeutic drug Doxorubicin is the most commonly prescribed in the world. However, its clinical wide application is limited due to harmful side effects like cardiotoxicity. ...
The chemotherapeutic drug Doxorubicin is the most commonly prescribed in the world. However, its clinical wide application is limited …
TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer.
Lynce F, Stevens LE, Li Z, Brock JE, Gulvady A, Huang Y, Nakhlis F, Patel A, Force JM, Haddad TC, Ueno N, Stearns V, Wolff AC, Clark AS, Bellon JR, Richardson ET, Balko JM, Krop IE, Winer EP, Lange P, Hwang ES, King TA, Tolaney SM, Thompson A, Gupta GP, Mittendorf EA, Regan MM, Overmoyer B, Polyak K. Lynce F, et al. Breast Cancer Res. 2024 Jan 31;26(1):20. doi: 10.1186/s13058-024-01774-0. Breast Cancer Res. 2024. PMID: 38297352 Free PMC article. Clinical Trial.
After the run-in, those who received RUX alone proceeded to neoadjuvant therapy with either RUX + PAC or PAC alone for 12 weeks; those who had received RUX + PAC continued treatment for 12 weeks. All patients subsequently received 4 cycles of doxorubicin plus cyclophospham …
After the run-in, those who received RUX alone proceeded to neoadjuvant therapy with either RUX + PAC or PAC alone for 12 weeks; those who h …
Recent development in graphdiyne and its derivative materials for novel biomedical applications.
Khan K, Tareen AK, Iqbal M, Mahmood A, Mahmood N, Shi Z, Yin J, Qing D, Ma C, Zhang H. Khan K, et al. J Mater Chem B. 2021 Dec 1;9(46):9461-9484. doi: 10.1039/d1tb01794b. J Mater Chem B. 2021. PMID: 34762090 Review.
GDY and its derivatives have also been used in cancer treatment due to their high doxorubicin (DOX) loading capacity (using-stacking) and photothermal conversion ability, and radiation protection since their initial biological use. ...
GDY and its derivatives have also been used in cancer treatment due to their high doxorubicin (DOX) loading capacity (using-stacking) …
Management of older Hodgkin lymphoma patients.
Evens AM, Carter J, Loh KP, David KA. Evens AM, et al. Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):233-242. doi: 10.1182/hematology.2019000028. Hematology Am Soc Hematol Educ Program. 2019. PMID: 31808898 Free PMC article.
Although inclusion of anthracycline therapy is important, bleomycin-containing regimens (eg, doxorubicin, bleomycin, vinblastine, dacarbazine) may lead to prohibitive pulmonary toxicity, and intensive therapies (eg, bleomycin, etoposide, doxorubicin, cyclophosphamid …
Although inclusion of anthracycline therapy is important, bleomycin-containing regimens (eg, doxorubicin, bleomycin, vinblastine, dac …
Lysosomal Biogenesis and Implications for Hydroxychloroquine Disposition.
Collins KP, Witta S, Coy JW, Pang Y, Gustafson DL. Collins KP, et al. J Pharmacol Exp Ther. 2021 Feb;376(2):294-305. doi: 10.1124/jpet.120.000309. Epub 2020 Nov 10. J Pharmacol Exp Ther. 2021. PMID: 33172973 Free PMC article.
This concept can be applied to many other lysosomotropic drugs that activate transcription factor EB, such as doxorubicin and other tyrosine kinase inhibitor drugs, as these drugs may actively increase their own sequestration within the lysosome to further exacerbate multi …
This concept can be applied to many other lysosomotropic drugs that activate transcription factor EB, such as doxorubicin and other t …
Vernonia amygdalina Ethanol Extract Protects against Doxorubicin-Induced Cardiotoxicity via TGFbeta, Cytochrome c, and Apoptosis.
Syahputra RA, Harahap U, Harahap Y, Gani AP, Dalimunthe A, Ahmed A, Zainalabidin S. Syahputra RA, et al. Molecules. 2023 May 24;28(11):4305. doi: 10.3390/molecules28114305. Molecules. 2023. PMID: 37298779 Free PMC article.
Doxorubicin (DOX) has been extensively utilized in cancer treatment. ...These findings suggest that Vernonia amygdalina may protect cardiac rats by reducing the apoptosis, TGF, and cytochrome c expression while not producing the doxorubicinol as doxorubicin metaboli …
Doxorubicin (DOX) has been extensively utilized in cancer treatment. ...These findings suggest that Vernonia amygdalina may protect c …
59 results