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Calorie Restriction Using High-Fat/Low-Carbohydrate Diet Suppresses Liver Fat Accumulation and Pancreatic Beta-Cell Dedifferentiation in Obese Diabetic Mice.
Lei X, Ishida E, Yoshino S, Matsumoto S, Horiguchi K, Yamada E. Lei X, et al. Among authors: ishida e. Nutrients. 2024 Mar 28;16(7):995. doi: 10.3390/nu16070995. Nutrients. 2024. PMID: 38613031 Free PMC article.
Recently, islet cell heterogeneity, exemplified by beta-cell dedifferentiation and identified in diabetic animals, has attracted attention as an underlying molecular mechanism of beta-cell dysfunction. ...In conclusion, the fat/carbohydrate ratio in food during calorie res …
Recently, islet cell heterogeneity, exemplified by beta-cell dedifferentiation and identified in diabetic animals, has attracted atte …
Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of beta-Cell Dedifferentiation in db/db Mice.
Ishida E, Kim-Muller JY, Accili D. Ishida E, et al. Diabetes. 2017 Aug;66(8):2092-2101. doi: 10.2337/db16-1213. Epub 2017 May 15. Diabetes. 2017. PMID: 28506962 Free PMC article.
Among several cellular biological mechanisms of cellular dysfunction, we and others have recently proposed that dedifferentiation of beta-cells can explain the slowly progressive onset and partial reversibility of beta-cell failure. ...However, pair feeding among the four …
Among several cellular biological mechanisms of cellular dysfunction, we and others have recently proposed that dedifferentiation of …
Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.
Kim-Muller JY, Fan J, Kim YJ, Lee SA, Ishida E, Blaner WS, Accili D. Kim-Muller JY, et al. Among authors: ishida e. Nat Commun. 2016 Aug 30;7:12631. doi: 10.1038/ncomms12631. Nat Commun. 2016. PMID: 27572106 Free PMC article.
Insulin-producing beta cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, initiates progression from beta-cell dysfunction to beta-cell dedifferentiation. The …
Insulin-producing beta cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidat …