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Page 1
Methyl-4-Hydroxybutyrate and Ethyl-4-Hydroxybutyrate as Potential Markers for Simultaneous Consumption of GHB/GBL and Alcohol: Preliminary Investigations.
Küting T, Beier N, Krämer M, Madea B. Küting T, et al. J Anal Toxicol. 2020 Dec 12;44(8):818-828. doi: 10.1093/jat/bkaa096. J Anal Toxicol. 2020. PMID: 32780806
Nearly no ethyl-4-hydroxybutyrate was observable in spirits/liqueurs and no methyl-4-hydroxybutyrate was detectable at all. A moderate correlation was shown between the ethyl-4-hydroxybutyrate concentration and the pH-value …
Nearly no ethyl-4-hydroxybutyrate was observable in spirits/liqueurs and no methyl-4-hydroxybutyrate was …
Surface glycosylation of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) membrane for selective adsorption of low-density lipoprotein.
Wang W, Lan P. Wang W, et al. J Biomater Sci Polym Ed. 2014;25(18):2094-112. doi: 10.1080/09205063.2014.970605. Epub 2014 Oct 29. J Biomater Sci Polym Ed. 2014. PMID: 25351372
A novel method of constructing a glycosylated surface on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] membrane surface for the selective adsorption of low-density lipoprotein (LDL) was developed, which involved the photoinduced graft polymerization o …
A novel method of constructing a glycosylated surface on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] membrane …
Determination of endogenous GHB levels in chest and pubic hair.
Bertol E, Mari F, Lachi A, Tespio G, Vaiano F. Bertol E, et al. Forensic Sci Int. 2021 Aug;325:110857. doi: 10.1016/j.forsciint.2021.110857. Epub 2021 Jun 1. Forensic Sci Int. 2021. PMID: 34098474
After acidification with H(2)SO(4), the solution was liquid-liquid extracted with ethyl acetate and a trimethylsilyl derivatization was then achieved. ...
After acidification with H(2)SO(4), the solution was liquid-liquid extracted with ethyl acetate and a trimethylsilyl derivatization w …
Simultaneous determination of GHB and EtG in hair using GCMS/MS.
Paul R, Tsanaclis L, Kingston R, Berry A, Guwy A. Paul R, et al. Drug Test Anal. 2011 Apr;3(4):201-5. doi: 10.1002/dta.172. Epub 2010 Oct 28. Drug Test Anal. 2011. PMID: 21500364
A gas chromatographic tandem mass spectrometric (GCMS/MS) method for simultaneously determining trace concentrations of gamma-hydroxybutyrate (GHB) and ethyl glucuronide (EtG) in hair has been developed. Multiple reaction monitoring (MRM) was used to detect precursor and p …
A gas chromatographic tandem mass spectrometric (GCMS/MS) method for simultaneously determining trace concentrations of gamma-hydroxybutyrat …
A potential new metabolite of gamma-hydroxybutyrate: sulfonated gamma-hydroxybutyric acid.
Hanisch S, Stachel N, Skopp G. Hanisch S, et al. Int J Legal Med. 2016 Mar;130(2):411-4. doi: 10.1007/s00414-015-1235-x. Epub 2015 Jul 26. Int J Legal Med. 2016. PMID: 26210636
Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuronide, the recently identified GHB-glucuronide exhibits a longer window of detection than the parent drug. ...
Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuronide, the recently iden …
gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors.
Schweitzer P, Roberto M, Madamba SG, Siggins GR. Schweitzer P, et al. J Pharmacol Exp Ther. 2004 Oct;311(1):172-9. doi: 10.1124/jpet.104.069534. Epub 2004 May 19. J Pharmacol Exp Ther. 2004. PMID: 15152029
The selective GABA(B) receptor antagonist CGP 55845 [3-N[1-(S)-(3,4-dichlorophenyl)ethyl]amino-2-(S)-hydroxypropyl-p-benzyl-phosphinic acid] blocked the effects of both GHB and baclofen, whereas the putative GHB receptor antagonist NCS-382 [(2E)-(5-hydroxy-5,7,8,9-tetrahyd …
The selective GABA(B) receptor antagonist CGP 55845 [3-N[1-(S)-(3,4-dichlorophenyl)ethyl]amino-2-(S)-hydroxypropyl-p-benzyl-phosphini …
Quantitative analysis of the endogenous GHB level in the hair of the Chinese population using GC/MS/MS.
Shi Y, Cui X, Shen M, Xiang P. Shi Y, et al. J Forensic Leg Med. 2016 Apr;39:10-5. doi: 10.1016/j.jflm.2016.01.002. Epub 2016 Jan 11. J Forensic Leg Med. 2016. PMID: 26807994
Hair was digested under alkaline conditions (1 mol/L NaOH, 90 C 10 min), and GHB-d6 was used as an internal standard. Before derivatization with BSTFA and ethyl acetate, a liquid-liquid extraction with ethyl acetate under acidic conditions was performed. ...
Hair was digested under alkaline conditions (1 mol/L NaOH, 90 C 10 min), and GHB-d6 was used as an internal standard. Before derivatization …
gamma-Hydroxybutyrate induces cyclic AMP-responsive element-binding protein phosphorylation in mouse hippocampus: an involvement of GABA(B) receptors and cAMP-dependent protein kinase activation.
Ren X, Mody I. Ren X, et al. Neuroscience. 2006 Aug 11;141(1):269-75. doi: 10.1016/j.neuroscience.2006.03.056. Epub 2006 May 3. Neuroscience. 2006. PMID: 16675135
Pretreatment with the specific GABA(B) receptor antagonist [3-[1-(R)-[(3-cyclohexylmethyl)hydroxyphosphinyl]-2-(S)-hydroxy-propyl]amino]ethyl]-benzoic acid (20 mg/kg, i.p.) prevented the action of gamma-hydroxybutyrate, confirming a GABA(B) receptor-mediated mechanism. ...
Pretreatment with the specific GABA(B) receptor antagonist [3-[1-(R)-[(3-cyclohexylmethyl)hydroxyphosphinyl]-2-(S)-hydroxy-propyl]amino]e …
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.
Kaupmann K, Cryan JF, Wellendorph P, Mombereau C, Sansig G, Klebs K, Schmutz M, Froestl W, van der Putten H, Mosbacher J, Bräuner-Osborne H, Waldmeier P, Bettler B. Kaupmann K, et al. Eur J Neurosci. 2003 Nov;18(10):2722-30. doi: 10.1111/j.1460-9568.2003.03013.x. Eur J Neurosci. 2003. PMID: 14656321
The GTPgamma[35S] responses in wild-type mice were blocked by the GABAB antagonist [3-[[1-(S)-(3,4dichlorophenyl)ethyl]amino]-2-(S)-hydroxy-propyl]-cyclohexylmethyl phosphinic acid hydrochloride (CGP54626) but not by NCS-382. ...
The GTPgamma[35S] responses in wild-type mice were blocked by the GABAB antagonist [3-[[1-(S)-(3,4dichlorophenyl)ethyl]amino]-2-(S)-h …
Discriminative stimulus effects of gamma-hydroxybutyrate: role of training dose.
Koek W, Chen W, Mercer SL, Coop A, France CP. Koek W, et al. J Pharmacol Exp Ther. 2006 Apr;317(1):409-17. doi: 10.1124/jpet.105.096909. Epub 2005 Dec 5. J Pharmacol Exp Ther. 2006. PMID: 16330491
The benzodiazepine antagonist flumazenil, the benzodiazepine inverse agonist ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-alpha]-[1,4]-benzodiazepine-3-carboxylate (Ro 15-4513), and the GHB receptor antagonist (2E)-5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annule …
The benzodiazepine antagonist flumazenil, the benzodiazepine inverse agonist ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-al …
28 results