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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1891 1
1903 1
1908 1
1909 1
1912 1
1914 1
1920 1
1921 1
1923 1
1928 2
1930 1
1942 1
1946 4
1947 3
1948 2
1949 1
1950 3
1951 1
1952 3
1953 2
1954 3
1955 3
1956 5
1957 4
1958 10
1959 5
1960 1
1961 8
1962 7
1963 4
1964 9
1965 12
1966 15
1967 26
1968 21
1969 17
1970 27
1971 25
1972 16
1973 28
1974 33
1975 88
1976 108
1977 93
1978 125
1979 122
1980 138
1981 154
1982 168
1983 260
1984 204
1985 272
1986 290
1987 322
1988 331
1989 439
1990 460
1991 582
1992 585
1993 627
1994 769
1995 816
1996 918
1997 957
1998 1131
1999 1228
2000 1637
2001 1765
2002 1942
2003 2328
2004 2673
2005 3209
2006 3552
2007 4031
2008 4352
2009 4928
2010 5696
2011 6563
2012 7193
2013 7953
2014 8817
2015 9725
2016 10515
2017 10996
2018 11861
2019 12577
2020 14383
2021 15593
2022 15806
2023 14695
2024 5611
2025 1

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180,509 results

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Page 1
Revisiting the Tenascins: Exploitable as Cancer Targets?
Tucker RP, Degen M. Tucker RP, et al. Front Oncol. 2022 Jun 17;12:908247. doi: 10.3389/fonc.2022.908247. eCollection 2022. Front Oncol. 2022. PMID: 35785162 Free PMC article. Review.
Although each have been described to be expressed in the ECM surrounding cancer cells, tenascin-C and tenascin-W are currently the most promising candidates for exploitability and clinical use as they are highly expressed in various tumor stroma with relatively low abundan …
Although each have been described to be expressed in the ECM surrounding cancer cells, tenascin-C and tenascin-W are currently the most prom …
Microtubule stabilising agents and ionising radiation: multiple exploitable mechanisms for combined treatment.
Rohrer Bley C, Furmanova P, Orlowski K, Grosse N, Broggini-Tenzer A, McSheehy PM, Pruschy M. Rohrer Bley C, et al. Eur J Cancer. 2013 Jan;49(1):245-53. doi: 10.1016/j.ejca.2012.05.008. Epub 2012 Jun 7. Eur J Cancer. 2013. PMID: 22683167 Free article. Review.
Apart from direct cytotoxicity and similar to mechanisms of molecular targeting agents, microtubule stabilising agents interfere with multiple cellular processes, which can be exploited as part of combined treatment modalities. Recent preclinical investigations on the comb …
Apart from direct cytotoxicity and similar to mechanisms of molecular targeting agents, microtubule stabilising agents interfere with multip …
Targeting synthetic lethal paralogs in cancer.
Ryan CJ, Mehta I, Kebabci N, Adams DJ. Ryan CJ, et al. Trends Cancer. 2023 May;9(5):397-409. doi: 10.1016/j.trecan.2023.02.002. Epub 2023 Mar 6. Trends Cancer. 2023. PMID: 36890003 Free article. Review.
Moreover, existing small-molecule drugs may exploit synthetic lethal interactions by inhibiting multiple paralogs simultaneously. ...Here we review approaches to identify such interactions and discuss some of the challenges of exploiting them....
Moreover, existing small-molecule drugs may exploit synthetic lethal interactions by inhibiting multiple paralogs simultaneously. ... …
Extending the gleaner-opportunist trade-off.
Yamamichi M, Letten AD. Yamamichi M, et al. J Anim Ecol. 2022 Nov;91(11):2163-2170. doi: 10.1111/1365-2656.13813. Epub 2022 Oct 24. J Anim Ecol. 2022. PMID: 36102615 Free PMC article. Review.
Pathogenic Exploitation of Lymphatic Vessels.
Magold AI, Swartz MA. Magold AI, et al. Cells. 2022 Mar 12;11(6):979. doi: 10.3390/cells11060979. Cells. 2022. PMID: 35326430 Free PMC article. Review.
At the same time, lymphatics help shape the nature and kinetics of immune responses to ensure resolution, limit tissue damage, and prevent autoimmune responses. A variety of pathogens have developed strategies to exploit these functions, from multicellular organisms like n …
At the same time, lymphatics help shape the nature and kinetics of immune responses to ensure resolution, limit tissue damage, and prevent a …
Understanding patch foraging strategies across development.
Lloyd A, Viding E, McKay R, Furl N. Lloyd A, et al. Trends Cogn Sci. 2023 Nov;27(11):1085-1098. doi: 10.1016/j.tics.2023.07.004. Epub 2023 Jul 25. Trends Cogn Sci. 2023. PMID: 37500422 Free article. Review.
We propose that neurocomputational mechanisms responsible for reward processing, learning, and cognitive control facilitate the transition from exploratory strategies in adolescence to exploitative strategies in adulthood - where individuals capitalise on known resources. …
We propose that neurocomputational mechanisms responsible for reward processing, learning, and cognitive control facilitate the transition f …
Child Labor and Sex Trafficking.
Greenbaum J. Greenbaum J. Pediatr Rev. 2021 Dec 1;42(12):639-654. doi: 10.1542/pir.2020-001396. Pediatr Rev. 2021. PMID: 34850175 Review.
Trafficked and exploited children can present with myriad physical or mental health conditions; most have experienced repeated, significant trauma; and few are likely to spontaneously disclose their exploitative situation. ...Knowledge of common risk factors and pot …
Trafficked and exploited children can present with myriad physical or mental health conditions; most have experienced repeated, signi …
Cancer cell survival depends on collagen uptake into tumor-associated stroma.
Hsu KS, Dunleavey JM, Szot C, Yang L, Hilton MB, Morris K, Seaman S, Feng Y, Lutz EM, Koogle R, Tomassoni-Ardori F, Saha S, Zhang XM, Zudaire E, Bajgain P, Rose J, Zhu Z, Dimitrov DS, Cuttitta F, Emenaker NJ, Tessarollo L, St Croix B. Hsu KS, et al. Nat Commun. 2022 Nov 18;13(1):7078. doi: 10.1038/s41467-022-34643-5. Nat Commun. 2022. PMID: 36400786 Free PMC article.
Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells. While tumor cells were unable to exploit collagen directly, here we show they can usurp metabolic byproduct …
Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabol …
Breaking the bonds of reinforcement: Effects of trial outcome, rule consistency and rule complexity against exploitable and unexploitable opponents.
Sundvall J, Dyson BJ. Sundvall J, et al. PLoS One. 2022 Feb 2;17(2):e0262249. doi: 10.1371/journal.pone.0262249. eCollection 2022. PLoS One. 2022. PMID: 35108279 Free PMC article.
Participants played the game against both computer opponents who could not be exploited and computer opponents who could be exploited by making choices that would at times conflict with reinforcement. Against unexploitable opponents, participants achieved an approxi …
Participants played the game against both computer opponents who could not be exploited and computer opponents who could be exploi …
The neurocomputational bases of explore-exploit decision-making.
Hogeveen J, Mullins TS, Romero JD, Eversole E, Rogge-Obando K, Mayer AR, Costa VD. Hogeveen J, et al. Neuron. 2022 Jun 1;110(11):1869-1879.e5. doi: 10.1016/j.neuron.2022.03.014. Epub 2022 Apr 6. Neuron. 2022. PMID: 35390278 Free PMC article.
Using the same task and a partially observable Markov decision process (POMDP) model to quantify the value of choices, we first determined that the computational basis for managing explore-exploit tradeoffs is conserved across monkeys and humans. We then used fMRI to ident …
Using the same task and a partially observable Markov decision process (POMDP) model to quantify the value of choices, we first determined t …
180,509 results
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