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Did you mean fedak (500 results)?
[(18)F]FEDAC translocator protein positron emission tomography-computed tomography for early detection of mitochondrial dysfunction secondary to myocardial ischemia.
Luo R, Wang L, Ye F, Wang YR, Fang W, Zhang MR, Wang F. Luo R, et al. Ann Nucl Med. 2021 Aug;35(8):927-936. doi: 10.1007/s12149-021-01630-7. Epub 2021 Jun 3. Ann Nucl Med. 2021. PMID: 34081287 Free PMC article.
We also assessed the feasibility of [18F]FEDAC for the early detection of mitochondrial dysfunction associated with myocardial ischemia (MI). METHODS: The radiochemical purity and stability of [(18)F]FEDAC were analyzed by radio-high-performance liquid chromatograph …
We also assessed the feasibility of [18F]FEDAC for the early detection of mitochondrial dysfunction associated with myocardial ischem …
(18)F-FEDAC as a Targeting Agent for Activated Macrophages in DBA/1 Mice with Collagen-Induced Arthritis: Comparison with (18)F-FDG.
Chung SJ, Yoon HJ, Youn H, Kim MJ, Lee YS, Jeong JM, Chung JK, Kang KW, Xie L, Zhang MR, Cheon GJ. Chung SJ, et al. J Nucl Med. 2018 May;59(5):839-845. doi: 10.2967/jnumed.117.200667. Epub 2018 Jan 11. J Nucl Med. 2018. PMID: 29326355 Free article.
We evaluated the feasibility of using (18)F-FEDAC in a murine RA model. Methods: RAW 264.7 mouse macrophages were activated by lipopolysaccharide. ...The results suggest the potential usefulness of (18)F-FEDAC imaging in the early phase of RA....
We evaluated the feasibility of using (18)F-FEDAC in a murine RA model. Methods: RAW 264.7 mouse macrophages were activated by lipopo …
Translocator protein imaging with (18)F-FEDAC-positron emission tomography in rabbit atherosclerosis and its presence in human coronary vulnerable plaques.
Maekawa K, Tsuji AB, Yamashita A, Sugyo A, Katoh C, Tang M, Nishihira K, Shibata Y, Koshimoto C, Zhang MR, Nishii R, Yoshinaga K, Asada Y. Maekawa K, et al. Atherosclerosis. 2021 Oct 12;337:7-17. doi: 10.1016/j.atherosclerosis.2021.10.003. Online ahead of print. Atherosclerosis. 2021. PMID: 34662838 Free article.
METHODS: (18)F-FEDAC-PET of a rabbit model of atherosclerosis induced by a 0.5% cholesterol diet and balloon injury of the left carotid artery (n = 7) was performed eight weeks after the injury. The autoradiography intensity of (18)F-FEDAC in carotid artery tissue s …
METHODS: (18)F-FEDAC-PET of a rabbit model of atherosclerosis induced by a 0.5% cholesterol diet and balloon injury of the left carot …
N-Benzyl-N-methyl-2-[7,8-dihydro-7-(2-[18F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide.
Leung K. Leung K. 2010 May 6 [updated 2010 Aug 19]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2010 May 6 [updated 2010 Aug 19]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20734501 Free Books & Documents. Review.
N-Benzyl-N-methyl-2-[7,8-dihydro-7-(2-[(18)F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide ([(18)F]FEDAC), which has an acetamide structure, has been evaluated for imaging PBR in the brain (13)....
N-Benzyl-N-methyl-2-[7,8-dihydro-7-(2-[(18)F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide ([(18)F]FEDAC), which has an acetami …
[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain.
Yanamoto K, Kumata K, Yamasaki T, Odawara C, Kawamura K, Yui J, Hatori A, Suzuki K, Zhang MR. Yanamoto K, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1707-10. doi: 10.1016/j.bmcl.2009.01.093. Epub 2009 Jan 31. Bioorg Med Chem Lett. 2009. PMID: 19217778
[(18)F]FEAC ([(18)F]4a) and [(18)F]FEDAC ([(18)F]4b) were developed as two novel positron emission tomography (PET) ligands for peripheral-type benzodiazepine receptor (PBR). [(18)F]4a and [(18)F]4b were synthesized by fluoroethylation of precursors 8a and 8b with [(18)F]F …
[(18)F]FEAC ([(18)F]4a) and [(18)F]FEDAC ([(18)F]4b) were developed as two novel positron emission tomography (PET) ligands for perip …
In vivo imaging of activated macrophages by (18)F-FEDAC, a TSPO targeting PET ligand, in the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs).
Chung SJ, Youn H, Jeong EJ, Park CR, Kim MJ, Kang KW, Zhang MR, Cheon GJ. Chung SJ, et al. Biochem Biophys Res Commun. 2018 Nov 17;506(1):216-222. doi: 10.1016/j.bbrc.2018.10.083. Epub 2018 Oct 19. Biochem Biophys Res Commun. 2018. PMID: 30343885
Interestingly, when we divided joints according to the degree of (18)F-FEDAC uptake before ETN treatment, the joints of high (18)F-FEDAC uptake showed better response to ETN than the joints with low (18)F-FEDAC uptakes. In case of (18)F-FDG, there was no such …
Interestingly, when we divided joints according to the degree of (18)F-FEDAC uptake before ETN treatment, the joints of high (18)F- …
PET imaging of lung inflammation with [18F]FEDAC, a radioligand for translocator protein (18 kDa).
Hatori A, Yui J, Yamasaki T, Xie L, Kumata K, Fujinaga M, Yoshida Y, Ogawa M, Nengaki N, Kawamura K, Fukumura T, Zhang MR. Hatori A, et al. PLoS One. 2012;7(9):e45065. doi: 10.1371/journal.pone.0045065. Epub 2012 Sep 12. PLoS One. 2012. PMID: 22984611 Free PMC article.
RESULTS: The uptake of [(18)F]FEDAC increased in the lung with the progress of inflammation by treatment with LPS. ...Study on human lung using [(18)F]FEDAC-PET is promising....
RESULTS: The uptake of [(18)F]FEDAC increased in the lung with the progress of inflammation by treatment with LPS. ...Study on human …
18F-FEAC and 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain.
Yui J, Maeda J, Kumata K, Kawamura K, Yanamoto K, Hatori A, Yamasaki T, Nengaki N, Higuchi M, Zhang MR. Yui J, et al. J Nucl Med. 2010 Aug;51(8):1301-9. doi: 10.2967/jnumed.109.072223. Epub 2010 Jul 21. J Nucl Med. 2010. PMID: 20660373 Free article.
RESULTS: (18)F-FEAC and (18)F-FEDAC had a high uptake of radioactivity in the heart, lung, and other TSPO-rich organs of mice. ...CONCLUSION: (18)F-FEAC and (18)F-FEDAC produced in vitro and in vivo signals allowing visualization of the increase in TSPO expression i …
RESULTS: (18)F-FEAC and (18)F-FEDAC had a high uptake of radioactivity in the heart, lung, and other TSPO-rich organs of mice. ...CON …
In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC.
Yanamoto K, Kumata K, Fujinaga M, Nengaki N, Takei M, Wakizaka H, Hosoi R, Momosaki S, Yamasaki T, Yui J, Kawamura K, Hatori A, Inoue O, Zhang MR. Yanamoto K, et al. Nucl Med Biol. 2010 Oct;37(7):853-60. doi: 10.1016/j.nucmedbio.2010.04.183. Nucl Med Biol. 2010. PMID: 20870161
Our laboratory developed N-benzyl-N-methyl-2-[7,8-dihydro-7-(2-[(18)F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide ([(18)F]FEDAC) as a TSPO positron emission tomography (PET) ligand. Here, using small-animal PET with [(18)F]FEDAC, we performed TSPO imaging an …
Our laboratory developed N-benzyl-N-methyl-2-[7,8-dihydro-7-(2-[(18)F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide ([(18)F]FEDAC …
Efficient radiosynthesis and non-clinical safety tests of the TSPO radioprobe [(18)F]FEDAC: Prerequisites for clinical application.
Kawamura K, Kumata K, Takei M, Furutsuka K, Hashimoto H, Ito T, Shiomi S, Fujishiro T, Watanabe R, Igarashi N, Muto M, Yamasaki T, Yui J, Xie L, Hatori A, Zhang Y, Nemoto K, Fujibayashi Y, Zhang MR. Kawamura K, et al. Nucl Med Biol. 2016 Jul;43(7):445-53. doi: 10.1016/j.nucmedbio.2016.04.004. Epub 2016 Apr 26. Nucl Med Biol. 2016. PMID: 27183465
INTRODUCTION: [(18)F]FEDAC ([(18)F]1) has potent binding affinity and selectivity for translocator protein (18kDa, TSPO), and has been used to noninvasively visualize neuroinflammation, lung inflammation, acute liver damage, nonalcoholic fatty liver disease, and liver fibr …
INTRODUCTION: [(18)F]FEDAC ([(18)F]1) has potent binding affinity and selectivity for translocator protein (18kDa, TSPO), and has bee …
19 results