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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 3
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1991 14
1992 14
1993 14
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1995 20
1996 14
1997 19
1998 18
1999 12
2000 16
2001 14
2002 14
2003 8
2004 8
2005 4
2006 6
2007 3
2008 4
2009 1
2010 1
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2012 3
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2024 0

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261 results

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Page 1
Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice.
Miyagishi H, Tsuji M, Miyagawa K, Kurokawa K, Mochida-Saito A, Takahashi K, Kosuge Y, Ishige K, Takeda H. Miyagishi H, et al. Brain Res. 2022 May 15;1783:147859. doi: 10.1016/j.brainres.2022.147859. Epub 2022 Mar 2. Brain Res. 2022. PMID: 35245487
Moreover, this emotional abnormality was alleviated by chronic treatment with flesinoxan, a serotonin (5-HT)(1A) receptor agonist. 5-HT(1A) receptor expression is regulated by several transcription factors such as nuclear deformed epidermal autoregulatory factor (NUDR/Deaf …
Moreover, this emotional abnormality was alleviated by chronic treatment with flesinoxan, a serotonin (5-HT)(1A) receptor agonist. 5- …
Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus.
Kurokawa K, Takahashi K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Kurokawa K, et al. Neurochem Int. 2021 Dec;151:105213. doi: 10.1016/j.neuint.2021.105213. Epub 2021 Oct 18. Neurochem Int. 2021. PMID: 34673172
Mice were exposed to repeated restraint stress for 4 h/day for 14 days as a stress-maladaptive model. Flesinoxan was given intraperitoneally immediately after the daily exposure to restraint stress. ...Hippocampal oligodendrogenesis were examined by immunohistochemistry. C …
Mice were exposed to repeated restraint stress for 4 h/day for 14 days as a stress-maladaptive model. Flesinoxan was given intraperit …
Serotonin 5-HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model.
Depoortère R, Bardin L, Varney MA, Newman-Tancredi A. Depoortère R, et al. ACS Chem Neurosci. 2019 Jul 17;10(7):3101-3107. doi: 10.1021/acschemneuro.8b00661. Epub 2019 Apr 2. ACS Chem Neurosci. 2019. PMID: 30929419
At 30 min before being placed in an open-field, both rats of the dyad were injected (i.p or s.c.) with either vehicle, diazepam (as a reference compound), or one of six 5-HT(1A) receptor agonists: NLX-101 (a.k.a. F15599), F13714, S15535, flesinoxan, 8-OH-DPAT, and buspiron …
At 30 min before being placed in an open-field, both rats of the dyad were injected (i.p or s.c.) with either vehicle, diazepam (as a refere …
A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation.
Li Y, Pehrson AL, Oosting RS, Gulinello M, Olivier B, Sanchez C. Li Y, et al. Neuropharmacology. 2017 Jul 15;121:89-99. doi: 10.1016/j.neuropharm.2017.04.017. Epub 2017 Apr 13. Neuropharmacology. 2017. PMID: 28414050
To investigate the mechanisms involved, sexual behavior was assessed in male and female rats after acute, and repeated (7 and 14 days) treatment with vortioxetine, flesinoxan (a 5-HT(1A) receptor agonist), CP-94253 (a 5-HT(1B) receptor agonist), or ondansetron (a 5-HT(3) r …
To investigate the mechanisms involved, sexual behavior was assessed in male and female rats after acute, and repeated (7 and 14 days) treat …
Involvement of 5-HT₇ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents.
Westrich L, Haddjeri N, Dkhissi-Benyahya O, Sánchez C. Westrich L, et al. Neuropharmacology. 2015 Feb;89:382-90. doi: 10.1016/j.neuropharm.2014.10.015. Neuropharmacology. 2015. PMID: 25446573 Free article.
.), alone or in combination with the 5-HT1A receptor agonist flesinoxan (2.5 mg/kg, s.c.) or the 5-HT7 receptor antagonist SB269970 (30 mg/kg, s.c.), just prior to activity onset revealed significant delays in wheel-running behavior. ...
.), alone or in combination with the 5-HT1A receptor agonist flesinoxan (2.5 mg/kg, s.c.) or the 5-HT7 receptor antagonist SB269970 ( …
Serotonin: a never-ending story.
Olivier B. Olivier B. Eur J Pharmacol. 2015 Apr 15;753:2-18. doi: 10.1016/j.ejphar.2014.10.031. Epub 2014 Nov 7. Eur J Pharmacol. 2015. PMID: 25446560 Review.
Most of the research work described has started from an industrial perspective, aimed at developing animals models for psychiatric diseases and leading to putative new innovative psychotropic drugs, like in the cases of the SSRI fluvoxamine, the serenic eltoprazine and the anxiol …
Most of the research work described has started from an industrial perspective, aimed at developing animals models for psychiatric diseases …
The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function.
Moha ou Maati H, Bourcier-Lucas C, Veyssiere J, Kanzari A, Heurteaux C, Borsotto M, Haddjeri N, Lucas G. Moha ou Maati H, et al. Brain Struct Funct. 2016 Jan;221(1):21-37. doi: 10.1007/s00429-014-0890-x. Epub 2014 Sep 19. Brain Struct Funct. 2016. PMID: 25233810
The combination of spadin with the 5-HT4 agonist RS 67333 paradoxically reduced 5-HT firing, an effect reversed by acutely administering the 5-HT1A agonist flesinoxan. It also had a robust synergetic effect on the expression of Zif268 within the DRN. ...
The combination of spadin with the 5-HT4 agonist RS 67333 paradoxically reduced 5-HT firing, an effect reversed by acutely administering the …
Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine--a quantitative EEG study in rats.
Leiser SC, Pehrson AL, Robichaud PJ, Sanchez C. Leiser SC, et al. Br J Pharmacol. 2014 Sep;171(18):4255-72. doi: 10.1111/bph.12782. Br J Pharmacol. 2014. PMID: 24846338 Free PMC article.
.): vehicle, vortioxetine (0.1, 1.0, 3.0, 10), 5-HT1A agonist flesinoxan (2.5), 5-HT3 antagonist ondansetron (0.30), 5-HT7 antagonist SB-269970-A (10), escitalopram (2.0), duloxetine (10) and vortioxetine plus flesinoxan. ...Quantitative spectral analyses showed vor …
.): vehicle, vortioxetine (0.1, 1.0, 3.0, 10), 5-HT1A agonist flesinoxan (2.5), 5-HT3 antagonist ondansetron (0.30), 5-HT7 antagonist …
Yokukansan, a traditional Japanese herbal medicine, alleviates the emotional abnormality induced by maladaptation to stress in mice.
Tsuji M, Takeuchi T, Miyagawa K, Ishii D, Imai T, Takeda K, Kitajima M, Takeda H. Tsuji M, et al. Phytomedicine. 2014 Feb 15;21(3):363-71. doi: 10.1016/j.phymed.2013.08.025. Epub 2013 Oct 13. Phytomedicine. 2014. PMID: 24129119
From the 3rd day of stress exposure, mice were given yokukansan orally (p.o.) or the 5-HT1A receptor agonist flesinoxan intraperitoneally (i.p.) immediately after the daily exposure to restraint stress. ...The decreased emotionality observed in stress-maladaptive mice was …
From the 3rd day of stress exposure, mice were given yokukansan orally (p.o.) or the 5-HT1A receptor agonist flesinoxan intraperitone …
Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats.
Li Y, Raaby KF, Sánchez C, Gulinello M. Li Y, et al. Behav Brain Res. 2013 Nov 1;256:520-8. doi: 10.1016/j.bbr.2013.09.002. Epub 2013 Sep 7. Behav Brain Res. 2013. PMID: 24016840
When administered acutely during PWD, the 5-HT(1A) receptor agonist, flesinoxan, significantly reduced immobility, whereas the 5-HT(1A) receptor antagonist, WAY-100635, increased immobility. ...The 5-HT(7) receptor antagonist, SB-269970, was inactive, although the 5-HT(7) …
When administered acutely during PWD, the 5-HT(1A) receptor agonist, flesinoxan, significantly reduced immobility, whereas the 5-HT(1 …
261 results