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Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice.
Li Y, Wu B, Hossain MJ, Quagliata L, O'Meara C, Wilkins MR, Corley S, Khachigian LM. Li Y, et al. J Transl Med. 2023 Jul 14;21(1):467. doi: 10.1186/s12967-023-04289-y. J Transl Med. 2023. PMID: 37452307 Free PMC article.
Flubendazole (FLU) is an anthelmintic that has been used to treat worm infections in humans and animals for decades. ...CONCLUSION: This study is the first to show that FLU can inhibit melanoma growth with PD-1 suppression in immunocompetent mice....
Flubendazole (FLU) is an anthelmintic that has been used to treat worm infections in humans and animals for decades. ...CONCLUSION: T …
Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells.
Čáňová K, Rozkydalová L, Vokurková D, Rudolf E. Čáňová K, et al. Toxicol In Vitro. 2018 Feb;46:313-322. doi: 10.1016/j.tiv.2017.10.025. Epub 2017 Oct 26. Toxicol In Vitro. 2018. PMID: 29107018
Flubendazole (FLU) is a widely used anthelmintic drug belonging to benzimidazole group. ...In the present study we have investigated cytotoxic effects of FLU on malignant melanoma using A-375, BOWES and RPMI-7951 cell lines representing diverse melanoma molec …
Flubendazole (FLU) is a widely used anthelmintic drug belonging to benzimidazole group. ...In the present study we have investigated …
The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation.
Li Y, Acharya G, Elahy M, Xin H, Khachigian LM. Li Y, et al. Cancer Lett. 2019 Sep 10;459:268-276. doi: 10.1016/j.canlet.2019.05.026. Epub 2019 May 23. Cancer Lett. 2019. PMID: 31128215
Here we demonstrate the ability of flubendazole to inhibit human melanoma growth and spread in mice. Flubendazole's ability to block tumor growth and spread was comparable to paclitaxel. ...Western blotting and flow cytometry revealed that flubendazole …
Here we demonstrate the ability of flubendazole to inhibit human melanoma growth and spread in mice. Flubendazole's abi …
Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
Čáňová K, Rozkydalová L, Rudolf E. Čáňová K, et al. Acta Medica (Hradec Kralove). 2017;60(1):5-11. doi: 10.14712/18059694.2017.44. Epub 2017 Apr 11. Acta Medica (Hradec Kralove). 2017. PMID: 28399389 Free article. Review.
Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. ...The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effect …
Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. ...The microtubule-disrupting properties of benzimi …
Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers.
Chen C, Ding Y, Liu H, Sun M, Wang H, Wu D. Chen C, et al. Int J Mol Sci. 2022 Jan 4;23(1):519. doi: 10.3390/ijms23010519. Int J Mol Sci. 2022. PMID: 35008943 Free PMC article. Review.
Flubendazole, belonging to benzimidazole, is a broad-spectrum insect repellent and has been repurposed as a promising anticancer drug. In recent years, many studies have shown that flubendazole plays an anti-tumor role in different types of cancers, including breast …
Flubendazole, belonging to benzimidazole, is a broad-spectrum insect repellent and has been repurposed as a promising anticancer drug …
An analysis of mitotic catastrophe induced cell responses in melanoma cells exposed to flubendazole.
Rudolf K, Rudolf E. Rudolf K, et al. Toxicol In Vitro. 2020 Oct;68:104930. doi: 10.1016/j.tiv.2020.104930. Epub 2020 Jul 8. Toxicol In Vitro. 2020. PMID: 32652169
The present study was designed to explore some of these endpoints; i.e. the apoptosis as well as autophagy and their related signaling in several stabilized cell lines as well as human explant melanoma cells treated with flubendazole (FLU). FLU-induced mitotic catas …
The present study was designed to explore some of these endpoints; i.e. the apoptosis as well as autophagy and their related signaling in se …