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Comparison of a dimethicone/antacid (Asilone gel) with an alginate/antacid (Gaviscon liquid) in the management of reflux oesophagitis.
Smart HL, Atkinson M. Smart HL, et al. J R Soc Med. 1990 Sep;83(9):554-6. doi: 10.1177/014107689008300907. J R Soc Med. 1990. PMID: 2213800 Free PMC article. Clinical Trial.
Fifty-three patients with symptomatic reflux oesophagitis were entered into a single centre randomized study comparing the effects of a dimethicone/antacid (Asilone Gel) and an alginate/antacid (Gaviscon liquid) on symptoms and endoscopic changes over an 8-week peri …
Fifty-three patients with symptomatic reflux oesophagitis were entered into a single centre randomized study comparing the effects of a dime …
A Randomized, controlled, crossover trial to investigate times to onset of the perception of soothing and cooling by over-the-counter heartburn treatments.
Strugala V, Dettmar PW, Sarratt K, Sykes J, Berry P, Thomas E. Strugala V, et al. J Int Med Res. 2010 Mar-Apr;38(2):449-57. doi: 10.1177/147323001003800208. J Int Med Res. 2010. PMID: 20515559 Free article. Clinical Trial.
Similarly, time to onset of cooling was perceived within 1.95 min, 1.23 min and 11.22 min for Gaviscon Liquid, Double Action Liquid and Powder Formulation, respectively. The results show that Gaviscon Liquid and Gaviscon Double Action soothe within 3.1 …
Similarly, time to onset of cooling was perceived within 1.95 min, 1.23 min and 11.22 min for Gaviscon Liquid, Double Action L …
Alginate-antacid combinations: raft formation and gastric retention studies.
Hampson FC, Jolliffe IG, Bakhtyari A, Taylor G, Sykes J, Johnstone LM, Dettmar PW. Hampson FC, et al. Drug Dev Ind Pharm. 2010 May;36(5):614-23. doi: 10.3109/03639040903388290. Drug Dev Ind Pharm. 2010. PMID: 19925256 Clinical Trial.
RESULT: GDAL had similar raft strength and improved raft resilience than Gaviscon Liquid (GL), and both were significantly greater than five other products tested. ...
RESULT: GDAL had similar raft strength and improved raft resilience than Gaviscon Liquid (GL), and both were significantly gre …
Development and characterization of novel ambroxol sustained-release oral suspensions based on drug-polymeric complexation and polymeric raft formation.
Bani-Jaber A, Abdullah S. Bani-Jaber A, et al. Pharm Dev Technol. 2020 Jul;25(6):666-675. doi: 10.1080/10837450.2020.1729799. Epub 2020 Feb 25. Pharm Dev Technol. 2020. PMID: 32067531
However, pH dissolution profiles of the optimum suspensions revealed less pH sensitivity of the release consequent to this replacement as well as more stable ABX release upon aging. Relative to Gaviscon liquid, the optimum suspensions formed rafts of similar strengt …
However, pH dissolution profiles of the optimum suspensions revealed less pH sensitivity of the release consequent to this replacement as we …