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Year Number of Results
1993 1
1997 1
1998 8
1999 24
2000 28
2001 40
2002 52
2003 28
2004 45
2005 46
2006 57
2007 44
2008 51
2009 55
2010 44
2011 39
2012 34
2013 49
2014 51
2015 51
2016 54
2017 47
2018 48
2019 40
2020 68
2021 63
2022 47
2023 38
2024 23

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1,042 results

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Page 1
Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial.
Bermejo J, Yotti R, García-Orta R, Sánchez-Fernández PL, Castaño M, Segovia-Cubero J, Escribano-Subías P, San Román JA, Borrás X, Alonso-Gómez A, Botas J, Crespo-Leiro MG, Velasco S, Bayés-Genís A, López A, Muñoz-Aguilera R, de Teresa E, González-Juanatey JR, Evangelista A, Mombiela T, González-Mansilla A, Elízaga J, Martín-Moreiras J, González-Santos JM, Moreno-Escobar E, Fernández-Avilés F; Sildenafil for Improving Outcomes after VAlvular Correction (SIOVAC) investigators. Bermejo J, et al. Eur Heart J. 2018 Apr 14;39(15):1255-1264. doi: 10.1093/eurheartj/ehx700. Eur Heart J. 2018. PMID: 29281101 Free PMC article. Clinical Trial.
We assigned 200 patients to receive sildenafil (40 mg three times daily, n = 104) or placebo (n = 96) for 6 months. ...Off-label usage of sildenafil for treating this source of left heart disease PH should be avoided. ...
We assigned 200 patients to receive sildenafil (40 mg three times daily, n = 104) or placebo (n = 96) for 6 months. ...Off-label usag …
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders.
Samidurai A, Xi L, Das A, Kukreja RC. Samidurai A, et al. Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:585-615. doi: 10.1146/annurev-pharmtox-040122-034745. Epub 2022 Oct 7. Annu Rev Pharmacol Toxicol. 2023. PMID: 36206989 Free article. Review.
Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and t …
Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets …
Lodenafil.
Alshehri YM, Al-Majed AA, Attwa MW, Bakheit AH. Alshehri YM, et al. Profiles Drug Subst Excip Relat Methodol. 2022;47:113-147. doi: 10.1016/bs.podrm.2021.10.004. Epub 2021 Dec 7. Profiles Drug Subst Excip Relat Methodol. 2022. PMID: 35396013 Review.
Lodenafil is a class of drugs called an inhibitor of PDE5 which also include a wide range of other erectile medicines, such as sildenafil, tadalafil and vardenafil. It is part of a new generation of PDE5 inhibitors that includes udenafil and avanafil. Lodenaf …
Lodenafil is a class of drugs called an inhibitor of PDE5 which also include a wide range of other erectile medicines, such as sil …
Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial.
Cooper TJ, Cleland JGF, Guazzi M, Pellicori P, Ben Gal T, Amir O, Al-Mohammad A, Clark AL, McConnachie A, Steine K, Dickstein K. Cooper TJ, et al. Eur J Heart Fail. 2022 Jul;24(7):1239-1248. doi: 10.1002/ejhf.2527. Epub 2022 Jun 6. Eur J Heart Fail. 2022. PMID: 35596935 Free PMC article. Clinical Trial.
Compared to placebo, sildenafil did not improve symptoms, quality of life, PASP or walk test distance. Sildenafil was generally well tolerated, but those assigned to sildenafil had numerically more serious adverse events (33% vs. 21%). ...
Compared to placebo, sildenafil did not improve symptoms, quality of life, PASP or walk test distance. Sildenafil was gener …
Cardiovascular safety of sildenafil.
Tran D, Howes LG. Tran D, et al. Drug Saf. 2003;26(7):453-60. doi: 10.2165/00002018-200326070-00002. Drug Saf. 2003. PMID: 12735784 Review.
A significant body of evidence now indicates that sildenafil generally has a good safety profile in men with erectile dysfunction and cardiovascular disease. ...Sildenafil appears to be generally well tolerated in most patients with chronic, stable car …
A significant body of evidence now indicates that sildenafil generally has a good safety profile in men with erectile dysfunct …
Sildenafil: two decades of benefits or risks?
Leoni LA, Leite GS, Wichi RB, Rodrigues B. Leoni LA, et al. Aging Male. 2013 Sep;16(3):85-91. doi: 10.3109/13685538.2013.801952. Epub 2013 Jun 12. Aging Male. 2013. PMID: 23758451 Review.
Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE-5). ...Since expiration, the drug has been marketed under various trade names or as generic drugs. Numerous clinical trials have been conducted …
Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE-5). ...Since expi …
Sildenafil citrate: a therapeutic update.
Boyce EG, Umland EM. Boyce EG, et al. Clin Ther. 2001 Jan;23(1):2-23. doi: 10.1016/s0149-2918(01)80027-8. Clin Ther. 2001. PMID: 11219477 Review.
BACKGROUND: Since its approval by the US Food and Drug Administration in March 1998, sildenafil citrate has been used by millions of men for the treatment of erectile dysfunction. ...In addition, patients taking drugs that inhibit the cytochrome P450 3A4 isoz …
BACKGROUND: Since its approval by the US Food and Drug Administration in March 1998, sildenafil citrate has been used by milli …
ATR-FTIR characterization of generic brand-named and counterfeit sildenafil- and tadalafil-based tablets found on the Brazilian market.
Coelho Neto J, Lisboa FLC. Coelho Neto J, et al. Sci Justice. 2017 Jul;57(4):283-295. doi: 10.1016/j.scijus.2017.04.009. Epub 2017 Apr 22. Sci Justice. 2017. PMID: 28606335
In this study, we present our findings in exploring ATR-FTIR spectral profiles for characterizing both genuine and questioned samples of several generic and brand-name sildenafil- and tadalafil-based tablets available on the Brazilian market, including Viagra and Ci …
In this study, we present our findings in exploring ATR-FTIR spectral profiles for characterizing both genuine and questioned samples of sev …
Should sildenafil be available over the counter?
Rubin N, Wylie K. Rubin N, et al. Br Med Bull. 2009;90:53-62. doi: 10.1093/bmb/ldp001. Epub 2009 Feb 9. Br Med Bull. 2009. PMID: 19208615 Review.
INTRODUCTION: This article considers the process of re-classification of prescription drugs from prescription-only medications to over-the-counter (OTC) prescription drugs. ...GROWING POINTS: While the decision for re-classification to OTC would depend on a number o …
INTRODUCTION: This article considers the process of re-classification of prescription drugs from prescription-only medications to ove …
Efficacy and Safety of Sildenafil in Men With Sexual Dysfunction and Spinal Cord Injury.
Ohl DA, Carlsson M, Stecher VJ, Rippon GA. Ohl DA, et al. Sex Med Rev. 2017 Oct;5(4):521-528. doi: 10.1016/j.sxmr.2017.01.007. Epub 2017 Mar 21. Sex Med Rev. 2017. PMID: 28341580 Review.

The percentage of successful intercourse attempts with sildenafil (53% vs 12%) and preference for sildenafil (96% vs 4%) vs placebo were significant (P < .001), including the subgroup with complete SCI. ...Sildenafil is an effective and well-tolerated trea

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The percentage of successful intercourse attempts with sildenafil (53% vs 12%) and preference for sildenafil (96% vs 4%) vs pl …
1,042 results