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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1929 1
1947 3
1949 1
1951 4
1952 3
1953 11
1954 7
1955 3
1956 8
1957 4
1958 9
1959 6
1960 2
1961 10
1962 8
1963 6
1964 31
1965 36
1966 37
1967 38
1968 49
1969 61
1970 57
1971 73
1972 62
1973 90
1974 109
1975 120
1976 139
1977 149
1978 177
1979 214
1980 285
1981 304
1982 331
1983 412
1984 512
1985 457
1986 529
1987 521
1988 575
1989 571
1990 586
1991 723
1992 690
1993 712
1994 669
1995 704
1996 727
1997 744
1998 686
1999 648
2000 716
2001 723
2002 678
2003 772
2004 816
2005 934
2006 952
2007 1006
2008 1023
2009 1026
2010 1140
2011 1173
2012 1223
2013 1261
2014 1227
2015 1180
2016 1125
2017 1153
2018 1158
2019 1178
2020 1155
2021 1045
2022 1026
2023 883
2024 437

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34,508 results

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Page 1
Alcohol ingestion, liver glutathione and lipoperoxidation: metabolic interrelations and pathological implications.
Videla LA, Valenzuela A. Videla LA, et al. Life Sci. 1982 Nov 29;31(22):2395-407. doi: 10.1016/0024-3205(82)90743-3. Life Sci. 1982. PMID: 6759830 Review.
Data reviewed here indicate that acute and chronic ethanol ingestion induce a decrease in the concentration of GSH and an increase in lipoperoxidation in the liver both in experimental animals and in man, changes that are closely interrelated GSH depletion is suggested to …
Data reviewed here indicate that acute and chronic ethanol ingestion induce a decrease in the concentration of GSH and an increase in lipope …
Intranuclear distribution, function and fate of glutathione and glutathione-S-conjugate in living rat hepatocytes studied by fluorescence microscopy.
Bellomo G, Palladini G, Vairetti M. Bellomo G, et al. Microsc Res Tech. 1997 Feb 15;36(4):243-52. doi: 10.1002/(SICI)1097-0029(19970215)36:4<243::AID-JEMT3>3.0.CO;2-N. Microsc Res Tech. 1997. PMID: 9140925 Review.
The availability of fluorescent probes to detect soluble and protein-bound thiols has made it possible to investigate some aspects of reduced glutathione (GSH) metabolism and function in intact rat hepatocytes and in hepatocyte nuclei. ...Concomitant biochemical stu …
The availability of fluorescent probes to detect soluble and protein-bound thiols has made it possible to investigate some aspects of reduce …
Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy.
Geenen S, du Preez FB, Snoep JL, Foster AJ, Sarda S, Kenna JG, Wilson ID, Westerhoff HV. Geenen S, et al. Biochim Biophys Acta. 2013 Oct;1830(10):4943-59. doi: 10.1016/j.bbagen.2013.04.014. Epub 2013 Apr 30. Biochim Biophys Acta. 2013. PMID: 23643929
To increase understanding of the dynamics of cellular glutathione homeostasis, we have developed an experiment-based mathematical model of the kinetics of the glutathione network. ...Use of the adaptive model to analyze the functioning of the glutathione …
To increase understanding of the dynamics of cellular glutathione homeostasis, we have developed an experiment-based mathematical mod …
Glutathione modulation and oxidative stress in human liver slices.
Vickers AE, Fisher RL, Sinclair JR. Vickers AE, et al. Curr Drug Discov Technol. 2010 Sep;7(3):154-69. doi: 10.2174/157016310793180530. Curr Drug Discov Technol. 2010. PMID: 20843295
Glutathione (GSH) levels are modulated in human liver slices to evaluate if drug induced liver injury is enhanced by a poor liver GSH status. ...MMI (500-1000 M) affected oxidative stress pathways and mitochondrial function, resulting in lower …
Glutathione (GSH) levels are modulated in human liver slices to evaluate if drug induced liver injury is enhanced by a …
Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney.
Puri RN, Meister A. Puri RN, et al. Proc Natl Acad Sci U S A. 1983 Sep;80(17):5258-60. doi: 10.1073/pnas.80.17.5258. Proc Natl Acad Sci U S A. 1983. PMID: 6577420 Free PMC article.
Administration of gamma-glutamylcysteinylglycyl monomethyl (or monoethyl) ester to mice leads to substantial increases in the levels of glutathione in the liver and kidney. Mice depleted of glutathione by treatment with buthionine sulfoximine, a potent inhibi …
Administration of gamma-glutamylcysteinylglycyl monomethyl (or monoethyl) ester to mice leads to substantial increases in the levels of g …
Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.
Carlson BA, Tobe R, Yefremova E, Tsuji PA, Hoffmann VJ, Schweizer U, Gladyshev VN, Hatfield DL, Conrad M. Carlson BA, et al. Redox Biol. 2016 Oct;9:22-31. doi: 10.1016/j.redox.2016.05.003. Epub 2016 May 26. Redox Biol. 2016. PMID: 27262435 Free PMC article.
Abrogation of selenoprotein expression in Gpx4(-/-) mice did not result in viable mice, indicating that the combined deficiency aggravated the loss of Gpx4 in liver. By contrast, combined Trsp/Txnrd1-deficient mice were born, but had significantly shorter lifespans than ei …
Abrogation of selenoprotein expression in Gpx4(-/-) mice did not result in viable mice, indicating that the combined deficiency aggravated t …
Glutathione and glutathione conjugate efflux from cultured liver cells.
Meredith MJ. Meredith MJ. Cell Biol Toxicol. 1991 Jan;7(1):15-33. doi: 10.1007/BF00121327. Cell Biol Toxicol. 1991. PMID: 1675926
Efflux of glutathione (GSH) and GSH-conjugates from cultured rat liver epithelial cell lines; the non-tumorigenic ARL-15C1 and the gamma-glutamyl transpeptidase containing, tumorigenic ARL-16T2, has been assessed under basal condition and during chronic treatment wi …
Efflux of glutathione (GSH) and GSH-conjugates from cultured rat liver epithelial cell lines; the non-tumorigenic ARL-15C1 and …
Exacerbation of gefitinib-induced liver injury by glutathione reduction in mice.
Oda S, Miyazaki N, Tsuneyama K, Yokoi T. Oda S, et al. J Toxicol Sci. 2020;45(8):493-502. doi: 10.2131/jts.45.493. J Toxicol Sci. 2020. PMID: 32741899 Free article.
It is associated with the occurrence of clinical drug-induced liver injury. Although GEF is metabolized to chemically reactive metabolites by cytochrome P450 3A and 1A enzymes and then conjugated to glutathione (GSH), whether these reactive metabolites contribute to …
It is associated with the occurrence of clinical drug-induced liver injury. Although GEF is metabolized to chemically reactive metabo …
Noninvasive monitoring of hepatic glutathione depletion through fluorescence imaging and blood testing.
Jiang X, Zhou Q, Du B, Li S, Huang Y, Chi Z, Lee WM, Yu M, Zheng J. Jiang X, et al. Sci Adv. 2021 Feb 19;7(8):eabd9847. doi: 10.1126/sciadv.abd9847. Print 2021 Feb. Sci Adv. 2021. PMID: 33608272 Free PMC article.
Hepatic glutathione plays a key role in regulating redox potential of the entire body, and its depletion is known to increase susceptibility to oxidative stress involved in many diseases. ...Here, we report that both in vivo fluorescence imaging and blood testing (the firs …
Hepatic glutathione plays a key role in regulating redox potential of the entire body, and its depletion is known to increase suscept …
Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver.
Ji B, Ito K, Sekine S, Tajima A, Horie T. Ji B, et al. Free Radic Biol Med. 2004 Dec 1;37(11):1718-29. doi: 10.1016/j.freeradbiomed.2004.08.020. Free Radic Biol Med. 2004. PMID: 15528031
Normal Sprague-Dawley rat (SDR) and Mrp2-deficient Eisai hyperbilirubinemic rat (EHBR) livers were perfused with 500 microM EA. The release of glutamic pyruvic transaminase (GPT) and thiobarbituric-acid-reactive substances (TBARS) from EHBR liver was markedly delaye …
Normal Sprague-Dawley rat (SDR) and Mrp2-deficient Eisai hyperbilirubinemic rat (EHBR) livers were perfused with 500 microM EA. The r …
34,508 results
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