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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1989 2
1990 2
1991 4
1992 4
1993 4
1994 5
1995 3
1996 8
1997 5
1998 2
1999 7
2000 6
2001 5
2002 2
2003 5
2004 10
2005 9
2006 6
2007 10
2008 10
2009 7
2010 10
2011 8
2012 9
2013 11
2014 18
2015 11
2016 20
2017 22
2018 25
2019 21
2020 17
2021 27
2022 24
2023 33
2024 17

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352 results

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Page 1
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress.
Raghu G, Berk M, Campochiaro PA, Jaeschke H, Marenzi G, Richeldi L, Wen FQ, Nicoletti F, Calverley PMA. Raghu G, et al. Curr Neuropharmacol. 2021;19(8):1202-1224. doi: 10.2174/1570159X19666201230144109. Curr Neuropharmacol. 2021. PMID: 33380301 Free PMC article. Review.
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing tripeptide glutathione (GSH), which is synthesized and maintained at high concentrations …
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous cellular process implicated in the etiology o …
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.
Gupta U, Ghosh S, Wallace CT, Shang P, Xin Y, Nair AP, Yazdankhah M, Strizhakova A, Ross MA, Liu H, Hose S, Stepicheva NA, Chowdhury O, Nemani M, Maddipatla V, Grebe R, Das M, Lathrop KL, Sahel JA, Zigler JS Jr, Qian J, Ghosh A, Sergeev Y, Handa JT, St Croix CM, Sinha D. Gupta U, et al. Autophagy. 2023 Jan;19(1):92-111. doi: 10.1080/15548627.2022.2062887. Epub 2022 Apr 26. Autophagy. 2023. PMID: 35473441 Free PMC article.
Here, we identify a molecular pathway whereby increased LCN2 elicits pathophysiology in the RPE, cells known to drive dry AMD pathology, thus providing a possible therapeutic strategy for a disease with no current treatment options.Abbreviations: ACTB: actin, beta; Ad-GFP: adenov …
Here, we identify a molecular pathway whereby increased LCN2 elicits pathophysiology in the RPE, cells known to drive dry AMD pathology, thu …
Air pollution and indoor settings.
Rosário Filho NA, Urrutia-Pereira M, D'Amato G, Cecchi L, Ansotegui IJ, Galán C, Pomés A, Murrieta-Aguttes M, Caraballo L, Rouadi P, Chong-Neto HJ, Peden DB. Rosário Filho NA, et al. World Allergy Organ J. 2021 Jan 7;14(1):100499. doi: 10.1016/j.waojou.2020.100499. eCollection 2021 Jan. World Allergy Organ J. 2021. PMID: 33510831 Free PMC article. Review.
Household air pollution (HAP) resulting from cooking with polluting ("dirty") fuels, which include coal, kerosene, and biomass (wood, charcoal, crop residues, and animal manure) is a global environmental health problem. Indoor pollutants are gases, particulates, toxins, an …
Household air pollution (HAP) resulting from cooking with polluting ("dirty") fuels, which include coal, kerosene, and biomass (wood, charco …
Antioxidant Defense and Pseudoexfoliation Syndrome: An Updated Review.
Mastronikolis S, Kagkelaris K, Pagkalou M, Tsiambas E, Plotas P, Georgakopoulos CD. Mastronikolis S, et al. Med Sci (Basel). 2022 Dec 14;10(4):68. doi: 10.3390/medsci10040068. Med Sci (Basel). 2022. PMID: 36548003 Free PMC article. Review.
Oxidative stress (OS) affects the anterior ocular tissues, rendering them susceptible to several eye diseases. On the other hand, protection of the eye from harmful factors is achieved by unique defense mechanisms, including enzymatic and non-enzymatic antioxidants. …
Oxidative stress (OS) affects the anterior ocular tissues, rendering them susceptible to several eye diseases. On the other hand, pro …
The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health.
Waugh DT. Waugh DT. Int J Environ Res Public Health. 2019 Mar 8;16(5):856. doi: 10.3390/ijerph16050856. Int J Environ Res Public Health. 2019. PMID: 30857240 Free PMC article. Review.
This study provides diverse lines of evidence demonstrating that fluoride (F) exposure contributes to degenerative eye diseases by stimulating or inhibiting biological pathways associated with the pathogenesis of cataract, age-related macular degeneration and glaucoma. ... …
This study provides diverse lines of evidence demonstrating that fluoride (F) exposure contributes to degenerative eye diseases by st …
New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans.
Babizhayev MA. Babizhayev MA. Am J Ther. 2010 Jul-Aug;17(4):373-89. doi: 10.1097/MJT.0b013e3181d6b6c3. Am J Ther. 2010. PMID: 20463577 Review.
A novel patented oral health supplement is presented which enhances the anticataract activity of eye drops and activates functional visual acuity. The clinical data demonstrate the effectiveness and safety of a combined oral health care treatment with amino a …
A novel patented oral health supplement is presented which enhances the anticataract activity of eye drops and activates funct …
The Role of Gut Microbiota in Glaucoma Progression and Other Retinal Diseases.
Chen J, Chen DF, Cho KS. Chen J, et al. Am J Pathol. 2023 Nov;193(11):1662-1668. doi: 10.1016/j.ajpath.2023.06.015. Epub 2023 Jul 23. Am J Pathol. 2023. PMID: 37490970 Review.
As a rapidly growing field, microbiota research offers novel approaches to promoting ocular health and treating major retinal diseases, such as glaucoma. Gut microbiota changes throughout life; however, certain patterns of population changes have been increasingly associat …
As a rapidly growing field, microbiota research offers novel approaches to promoting ocular health and treating major retinal disease …
Molecular Mechanisms of Iron Mediated Programmed Cell Death and Its Roles in Eye Diseases.
Zhang J, Sheng S, Wang W, Dai J, Zhong Y, Ren J, Jiang K, Li S, Bian X, Liu L. Zhang J, et al. Front Nutr. 2022 Apr 5;9:844757. doi: 10.3389/fnut.2022.844757. eCollection 2022. Front Nutr. 2022. PMID: 35495915 Free PMC article. Review.
Its main characteristics commonly involve excess iron accumulation, elevated lipid peroxides and reactive oxygen species, and reduced levels of glutathione and glutathione peroxidase 4 levels. The effects of ferroptosis in eye diseases cannot be underestimate …
Its main characteristics commonly involve excess iron accumulation, elevated lipid peroxides and reactive oxygen species, and reduced levels …
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film.
Li S, Tang L, Zhou J, Anchouche S, Li D, Yang Y, Liu Z, Wu J, Hu J, Zhou Y, Yin J, Liu Z, Li W. Li S, et al. Stem Cell Reports. 2022 May 10;17(5):1105-1119. doi: 10.1016/j.stemcr.2022.03.017. Epub 2022 Apr 28. Stem Cell Reports. 2022. PMID: 35487212 Free PMC article.
Sleep deficiency, a common public health problem, causes ocular discomfort and affects ocular surface health. ...Exogenous hydrogen peroxide (H(2)O(2)) could directly stimulate the proliferation of CEPCs in vivo and in vitro. Topical treatment of antioxidant L-gl …
Sleep deficiency, a common public health problem, causes ocular discomfort and affects ocular surface health. ...Exogenous hyd …
Novel roles for the lens in preserving overall ocular health.
Lim JC, Umapathy A, Grey AC, Vaghefi E, Donaldson PJ. Lim JC, et al. Exp Eye Res. 2017 Mar;156:117-123. doi: 10.1016/j.exer.2016.05.027. Epub 2016 Jun 6. Exp Eye Res. 2017. PMID: 27282996 Review.
Outside the traditional roles of the lens as an important refractive element and a UV filter, it was David Beebe's group that first demonstrated that the lens acts an oxygen sink that protects the tissues of the anterior segment of the eye from oxygen or oxygen metabolites …
Outside the traditional roles of the lens as an important refractive element and a UV filter, it was David Beebe's group that first demonstr …
352 results