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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1982 1
1993 1
1994 2
1995 1
1996 2
1998 2
1999 4
2000 3
2001 1
2002 3
2003 3
2004 5
2005 4
2006 10
2007 8
2008 8
2009 6
2010 10
2011 11
2012 15
2013 9
2014 14
2015 11
2016 12
2017 6
2018 17
2019 22
2020 18
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2023 16
2024 4

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233 results

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Page 1
The Role of Glutathione in Age-Related Macular Degeneration (AMD).
Brodzka S, Baszyński J, Rektor K, Hołderna-Bona K, Stanek E, Kurhaluk N, Tkaczenko H, Malukiewicz G, Woźniak A, Kamiński P. Brodzka S, et al. Int J Mol Sci. 2024 Apr 9;25(8):4158. doi: 10.3390/ijms25084158. Int J Mol Sci. 2024. PMID: 38673745 Free PMC article. Review.
Age-related macular degeneration (AMD) is a chronic disease that usually develops in older people. ...Unspecific results of many of the parameters that make up the glutathione system show many unknowns. It is so important to conduct further research to unders …
Age-related macular degeneration (AMD) is a chronic disease that usually develops in older people. ...Unspecific results of ma …
Interferon-gamma induces retinal pigment epithelial cell Ferroptosis by a JAK1-2/STAT1/SLC7A11 signaling pathway in Age-related Macular Degeneration.
Wei TT, Zhang MY, Zheng XH, Xie TH, Wang W, Zou J, Li Y, Li HY, Cai J, Wang X, Tan J, Yang X, Yao Y, Zhu L. Wei TT, et al. FEBS J. 2022 Apr;289(7):1968-1983. doi: 10.1111/febs.16272. Epub 2021 Nov 22. FEBS J. 2022. PMID: 34741776 Free article.
Retinal pigment epithelium (RPE) cell damage is implicated in the pathogenesis of age-related macular degeneration (AMD). An increase of interferon-gamma (IFN-gamma) levels was observed in patients with AMD, but whether inflammatory factors are causally related to A …
Retinal pigment epithelium (RPE) cell damage is implicated in the pathogenesis of age-related macular degeneration (AMD). An i …
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.
Gupta U, Ghosh S, Wallace CT, Shang P, Xin Y, Nair AP, Yazdankhah M, Strizhakova A, Ross MA, Liu H, Hose S, Stepicheva NA, Chowdhury O, Nemani M, Maddipatla V, Grebe R, Das M, Lathrop KL, Sahel JA, Zigler JS Jr, Qian J, Ghosh A, Sergeev Y, Handa JT, St Croix CM, Sinha D. Gupta U, et al. Autophagy. 2023 Jan;19(1):92-111. doi: 10.1080/15548627.2022.2062887. Epub 2022 Apr 26. Autophagy. 2023. PMID: 35473441 Free PMC article.
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. ...Sub-retinal injection of the LCN2 homodimer secreted by RPE cells into NOD-SCID mice leads to re …
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD path …
Ferroptosis: mechanisms and advances in ocular diseases.
Liu K, Li H, Wang F, Su Y. Liu K, et al. Mol Cell Biochem. 2023 Sep;478(9):2081-2095. doi: 10.1007/s11010-022-04644-5. Epub 2023 Jan 8. Mol Cell Biochem. 2023. PMID: 36617346 Review.
Ferroptosis is mainly characterized by excess iron accumulation, elevated lipid peroxides and reactive oxygen species, and reduced levels of glutathione and glutathione peroxidase 4. The vast emerging literature on ferroptosis has shown that numerous diseases, such …
Ferroptosis is mainly characterized by excess iron accumulation, elevated lipid peroxides and reactive oxygen species, and reduced levels of …
Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis.
Yang M, Tsui MG, Tsang JKW, Goit RK, Yao KM, So KF, Lam WC, Lo ACY. Yang M, et al. Cell Death Dis. 2022 May 18;13(5):468. doi: 10.1038/s41419-022-04924-4. Cell Death Dis. 2022. PMID: 35585057 Free PMC article.
Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal disorders such as retinal degeneration (RD) and age-related macular degeneration (AMD). ...Ferroptosis, a novel regulated cell death pathway, participates in ca …
Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal disorders such as retinal degeneration …
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.
Sun Y, Zheng Y, Wang C, Liu Y. Sun Y, et al. Cell Death Dis. 2018 Jul 9;9(7):753. doi: 10.1038/s41419-018-0794-4. Cell Death Dis. 2018. PMID: 29988039 Free PMC article.
Glutathione (GSH) protects against oxidative damage in many tissues, including retinal pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and subsequent death of photoreceptors have been observed in age-related macular degeneration …
Glutathione (GSH) protects against oxidative damage in many tissues, including retinal pigment epithelium (RPE). Oxidative stress-med …
The macular carotenoids: A biochemical overview.
Arunkumar R, Gorusupudi A, Bernstein PS. Arunkumar R, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158617. doi: 10.1016/j.bbalip.2020.158617. Epub 2020 Jan 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 31931175 Free PMC article. Review.
These retinal carotenoids are collectively referred to as the macular pigment (MP) and are obtained only through dietary sources such as green leafy vegetables and yellow and orange fruits and vegetables. ...
These retinal carotenoids are collectively referred to as the macular pigment (MP) and are obtained only through dietary sources such …
(4S)-4-(3-[18F]Fluoropropyl)-l-glutamate.
Chopra A. Chopra A. 2013 Mar 20 [updated 2013 May 23]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2013 Mar 20 [updated 2013 May 23]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 23700646 Free Books & Documents. Review.
Cysteine is not only a component of most proteins; it is also required for the synthesis of glutathione (GSH; a l-gamma-glutamyl-l-cysteinyl-glycine tripeptide), an important detoxifier that scavenges and reduces the reactive oxygen or nitrogen species (RO/NS) generated du …
Cysteine is not only a component of most proteins; it is also required for the synthesis of glutathione (GSH; a l-gamma-glutamyl-l-cy …
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration.
Advani J, Corso-Diaz X, Kwicklis M, van Asten F, Ratnapriya R, Mehta P, Hamel A, Mahrotra S, Segrè A, Kiel C, Strunz T, Weber B, Chew E, Hernandez D, Montezuma S, Ferrington D, Swaroop A. Advani J, et al. Res Sq [Preprint]. 2023 Jun 16:rs.3.rs-3011096. doi: 10.21203/rs.3.rs-3011096/v1. Res Sq. 2023. PMID: 37398472 Free PMC article. Updated. Preprint.
Summary data-based Mendelian randomization and colocalization analyses identify 87 target genes where methylation and gene-expression changes likely mediate the genotype effect on age-related macular degeneration (AMD). Integrated pathway analysis reveals epigenetic …
Summary data-based Mendelian randomization and colocalization analyses identify 87 target genes where methylation and gene-expression change …
Dysregulated metabolic pathways in age-related macular degeneration.
Zhang M, Jiang N, Chu Y, Postnikova O, Varghese R, Horvath A, Cheema AK, Golestaneh N. Zhang M, et al. Sci Rep. 2020 Feb 12;10(1):2464. doi: 10.1038/s41598-020-59244-4. Sci Rep. 2020. PMID: 32051464 Free PMC article.
Age-related macular degeneration is a major cause of vision impairment in the Western world among people of 55 years and older. ...Metabolomics and lipidomics revealed dysregulated metabolites in AMD RPE as compared to normal RPE, including glycerophospholipid metab …
Age-related macular degeneration is a major cause of vision impairment in the Western world among people of 55 years and older …
233 results