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1983 1
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Page 1
Evaluation of guanfacine as a potential medication for alcohol use disorder in long-term drinking rats: behavioral and electrophysiological findings.
Fredriksson I, Jayaram-Lindström N, Wirf M, Nylander E, Nyström E, Jardemark K, Steensland P. Fredriksson I, et al. Neuropsychopharmacology. 2015 Mar 13;40(5):1130-40. doi: 10.1038/npp.2014.294. Neuropsychopharmacology. 2015. PMID: 25359257 Free PMC article.
In addition, guanfacine attenuated the ADE as well as alcohol seeking and cue/priming-induced reinstatement of alcohol seeking. ...Together with the fact that guanfacine appears to be clinically safe, these results merit evaluation of guanfacine's clinical ef …
In addition, guanfacine attenuated the ADE as well as alcohol seeking and cue/priming-induced reinstatement of alcohol seeking. ...To …
Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats.
Lê AD, Funk D, Juzytsch W, Coen K, Navarre BM, Cifani C, Shaham Y. Lê AD, et al. Psychopharmacology (Berl). 2011 Nov;218(1):89-99. doi: 10.1007/s00213-011-2178-7. Epub 2011 Feb 12. Psychopharmacology (Berl). 2011. PMID: 21318567 Free PMC article.
Here, we further addressed this issue by studying the effect of the alpha-1 adrenoceptor antagonist prazosin and the alpha-2 adrenoceptor agonist guanfacine on yohimbine-induced reinstatement. METHODS: In exp. 1, we trained rats to self-administer alcohol (12% w/v, 1 h/day …
Here, we further addressed this issue by studying the effect of the alpha-1 adrenoceptor antagonist prazosin and the alpha-2 adrenoceptor ag …
A sustained depressive state promotes a guanfacine reversible susceptibility to alcohol seeking in rats.
Riga D, Schmitz LJ, van der Harst JE, van Mourik Y, Hoogendijk WJ, Smit AB, De Vries TJ, Spijker S. Riga D, et al. Neuropsychopharmacology. 2014 Apr;39(5):1115-24. doi: 10.1038/npp.2013.311. Epub 2013 Nov 6. Neuropsychopharmacology. 2014. PMID: 24192553 Free PMC article.
Subsequently, animals were subjected to a 5-month operant alcohol SA paradigm, examining acquisition, motivation, extinction, and cue-induced reinstatement of alcohol seeking. The effects of guanfacine on motivation and relapse were measured at >6 months following defea …
Subsequently, animals were subjected to a 5-month operant alcohol SA paradigm, examining acquisition, motivation, extinction, and cue-induce …
Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments.
Fox HC, Milivojevic V, Sinha R. Fox HC, et al. Handb Exp Pharmacol. 2023;282:127-161. doi: 10.1007/164_2023_687. Handb Exp Pharmacol. 2023. PMID: 37592081
We additionally discuss the efficacy of these mechanisms as novel targets for medications development, using exogenous progesterone and guanfacine as examples. Finally, we assess some of the challenges faced and progress made in terms of developing innovative medications i …
We additionally discuss the efficacy of these mechanisms as novel targets for medications development, using exogenous progesterone and g …
Role of alpha-2 adrenergic and kappa opioid receptors in the effects of alcohol gavage-induced dependence on alcohol seeking.
Funk D, Mak D, Coen K, Lê AD. Funk D, et al. Behav Brain Res. 2022 Sep 26;434:114032. doi: 10.1016/j.bbr.2022.114032. Epub 2022 Jul 29. Behav Brain Res. 2022. PMID: 35908667
The influence of these variables on the inhibitory effects of the alpha-2 agonist guanfacine on ASA, and on reinstatement induced by the alpha-2 antagonist yohimbine were determined. ...Alcohol dependence did not modify the inhibitory effects of guanfacine on ASA in …
The influence of these variables on the inhibitory effects of the alpha-2 agonist guanfacine on ASA, and on reinstatement induced by …
The effect of clonidine and related substances on voluntary ethanol consumption in rats.
Opitz K. Opitz K. Drug Alcohol Depend. 1990 Feb;25(1):43-8. doi: 10.1016/0376-8716(90)90139-6. Drug Alcohol Depend. 1990. PMID: 1969792
Clonidine, guanfacine and tiamenidine, in equihypotensive doses, significantly reduced alcohol intake in ethanol-preferring rats having free choice between 10% ethanol and drinking water. ...Simultaneous treatment with yohimbine attenuated the clonidine-induc …
Clonidine, guanfacine and tiamenidine, in equihypotensive doses, significantly reduced alcohol intake in ethanol-preferring ra …
Functional effects of alcohol withdrawal syndrome on peripheral sympathetic neurotransmission in vas deferens of adult rats.
Bomfim GH, Verde LF, Frussa-Filho R, Jurkiewicz A, Jurkiewicz NH. Bomfim GH, et al. Life Sci. 2014 Jul 11;108(1):34-43. doi: 10.1016/j.lfs.2014.05.002. Epub 2014 May 14. Life Sci. 2014. PMID: 24831557
AIMS: Alcohol withdrawal syndrome (AWS) is characterized by a set of physiological modifications triggered by abrupt withdrawal and/or decreasing consumption of ethanol (EtOH), which may manifest 16-48 h after ceasing consumption. ...KEY FINDINGS: The results showed that t …
AIMS: Alcohol withdrawal syndrome (AWS) is characterized by a set of physiological modifications triggered by abrupt withdrawal and/or decre …
Studies with alpha 2-adrenoceptor agonists and alcohol abstinence syndrome in rats.
Parale MP, Kulkarni SK. Parale MP, et al. Psychopharmacology (Berl). 1986;88(2):237-9. doi: 10.1007/BF00652247. Psychopharmacology (Berl). 1986. PMID: 2869542
The volume of fluid intake was measured every 12 h to determine daily ethanol consumption. Abstinence signs following abrupt alcohol withdrawal were observed in control as well as test groups receiving various alpha 2-adrenoceptor agonists. Clonidine, guanfacine and …
The volume of fluid intake was measured every 12 h to determine daily ethanol consumption. Abstinence signs following abrupt alcohol …
Sleeping times evoked by alpha adrenoceptor agonists in two-day-old chicks: an experimental model to evaluate full and partial agonists at central alpha-2 adrenoceptors.
Roach AG, Doxey JC, Strachan DA, Cavero I. Roach AG, et al. J Pharmacol Exp Ther. 1983 Nov;227(2):421-8. J Pharmacol Exp Ther. 1983. PMID: 6138427
The ability of a series of alpha adrenoceptor agonists to induce a sleep-like state (as measured by the time interval between the loss and regaining of the righting reflex) has been assessed in 2-day-old chicks in order to understand their pharmacological profile better. Guanaben …
The ability of a series of alpha adrenoceptor agonists to induce a sleep-like state (as measured by the time interval between the loss and r …