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Showing results for haloperidol herein
Your search for haloperidol-ferein retrieved no results
Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects.
Natfji AA, Nikitin DO, Semina II, Moustafine RI, Khutoryanskiy VV, Lin H, Stephens GJ, Watson KA, Osborn HMI, Greco F. Natfji AA, et al. J Control Release. 2020 Jun 10;322:227-235. doi: 10.1016/j.jconrel.2020.02.037. Epub 2020 Feb 26. J Control Release. 2020. PMID: 32112855
We hypothesised that this polymer-drug conjugate would localise haloperidol's activity either centrally or peripherally, dependent on the location of administration, due to the polymer preventing penetration through the blood-brain barrier (BBB). Herein, we v …
We hypothesised that this polymer-drug conjugate would localise haloperidol's activity either centrally or peripherally, depen …
Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma.
Barbaraci C, Giurdanella G, Leotta CG, Longo A, Amata E, Dichiara M, Pasquinucci L, Turnaturi R, Prezzavento O, Cacciatore I, Zuccarello E, Lupo G, Pitari GM, Anfuso CD, Marrazzo A. Barbaraci C, et al. J Med Chem. 2021 Sep 23;64(18):13622-13632. doi: 10.1021/acs.jmedchem.1c00995. Epub 2021 Sep 3. J Med Chem. 2021. PMID: 34477381 Free PMC article.
Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults. ()-MRJF22, a prodrug of the sigma (sigma) ligand haloperidol metabolite II conju …
Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma …
Haloperidol-induced sudden cardiac arrest in a recently detected HIV and hepatitis C patient: A unique case report.
Tamang K, Kc B, Kuikel S, Thapa S. Tamang K, et al. SAGE Open Med Case Rep. 2023 Dec 20;11:2050313X231220792. doi: 10.1177/2050313X231220792. eCollection 2023. SAGE Open Med Case Rep. 2023. PMID: 38130911 Free PMC article.
We herein described a case of a 45-year-old male recently detected with HIV and Hepatitis C who presented with signs of sepsis, developed delirium, and received haloperidol. ...The report discusses the limited instances of cardiac arrest linked to haloperidol
We herein described a case of a 45-year-old male recently detected with HIV and Hepatitis C who presented with signs of sepsis, devel …
Amisulpride - is it as all other medicines or is it different? An update.
Hadryś T, Rymaszewska J. Hadryś T, et al. Psychiatr Pol. 2020 Oct 31;54(5):977-989. doi: 10.12740/PP/OnlineFirst/109129. Epub 2020 Oct 31. Psychiatr Pol. 2020. PMID: 33529280 Free article. Review. English, Polish.
Since new publications of comparative drug trials, meta-analyses and systematic reviews are issued regularly, the authors present herein publications issued within last ten years focusing on amisulpride as opposed to other neuroleptics used in Poland. ...Amisulpride seems …
Since new publications of comparative drug trials, meta-analyses and systematic reviews are issued regularly, the authors present herein
Insights into the biased activity of dextromethorphan and haloperidol towards SARS-CoV-2 NSP6: in silico binding mechanistic analysis.
Pandey P, Prasad K, Prakash A, Kumar V. Pandey P, et al. J Mol Med (Berl). 2020 Dec;98(12):1659-1673. doi: 10.1007/s00109-020-01980-1. Epub 2020 Sep 23. J Mol Med (Berl). 2020. PMID: 32965508 Free PMC article.
To explore the potential mechanisms of biased binding and activity of the two drugs, haloperidol and dextromethorphan towards NSP6, we herein utilized molecular docking-based molecular dynamics simulation studies. ...Thus, the structural insights of stronger binding …
To explore the potential mechanisms of biased binding and activity of the two drugs, haloperidol and dextromethorphan towards NSP6, w …
Influence of CYP3A5 polymorphism on the pharmacokinetics of psychiatric drugs.
Ragia G, Dahl ML, Manolopoulos VG. Ragia G, et al. Curr Drug Metab. 2016;17(3):227-36. doi: 10.2174/1389200217666151210125831. Curr Drug Metab. 2016. PMID: 26651976 Review.
BACKGROUND: The contribution of the CYP3A5 enzyme to the metabolism of clinically used drugs has been established only for a few CYP3A substrates, such as the immunosuppressant tacrolimus, while for drugs used in the field of psychiatry its role is still vague. METHODS: We her
BACKGROUND: The contribution of the CYP3A5 enzyme to the metabolism of clinically used drugs has been established only for a few CYP3A subst …
Gnal haploinsufficiency causes genomic instability and increased sensitivity to haloperidol.
Khan MM, Xiao J, Hollingsworth TJ, Patel D, Selley DE, Ring TL, LeDoux MS. Khan MM, et al. Exp Neurol. 2019 Aug;318:61-70. doi: 10.1016/j.expneurol.2019.04.014. Epub 2019 Apr 26. Exp Neurol. 2019. PMID: 31034808 Free PMC article.
Administration of haloperidol promotes cAMP-dependent signaling in D2R-expressing indirect pathway MSNs. At present, little is known about the cellular relationships among isolated, acute, and tardive dystonia. Herein, we report the effects of acute D2R blockade on …
Administration of haloperidol promotes cAMP-dependent signaling in D2R-expressing indirect pathway MSNs. At present, little is known …
The modulation of carbonyl reductase 1 by polyphenols.
Boušová I, Skálová L, Souček P, Matoušková P. Boušová I, et al. Drug Metab Rev. 2015;47(4):520-33. doi: 10.3109/03602532.2015.1089885. Epub 2015 Sep 29. Drug Metab Rev. 2015. PMID: 26415702 Review.
Plant polyphenols are not only present in many human food sources, but are also a component of many popular dietary supplements and herbal medicines. Many studies reviewed herein have demonstrated the potency of certain flavonoids, stilbenes and curcuminoids in the inhibit …
Plant polyphenols are not only present in many human food sources, but are also a component of many popular dietary supplements and herbal m …
Vortioxetine improved negative and cognitive symptoms of schizophrenia in subchronic MK-801 model in rats.
Bozkurt NM, Unal G. Bozkurt NM, et al. Behav Brain Res. 2023 Apr 27;444:114365. doi: 10.1016/j.bbr.2023.114365. Epub 2023 Feb 27. Behav Brain Res. 2023. PMID: 36858318
Female Wistar albino rats (10-12 weeks) were grouped as saline, MK-801 (0.2 mg/kg), MK-801 + vortioxetine (2.5 mg/kg), MK-801 + vortioxetine (5 mg/kg), MK-801 + vortioxetine (10 mg/kg), MK-801 + risperidone (0.3 mg/kg), MK-801 + haloperidol (1 mg/kg) (n = 8 in each group). …
Female Wistar albino rats (10-12 weeks) were grouped as saline, MK-801 (0.2 mg/kg), MK-801 + vortioxetine (2.5 mg/kg), MK-801 + vortioxetine …
Status dystonicus associated with CLN8 disease.
Yıldırım M, Köse E, Keçeli AM, Balasar Ö, Şimşek N. Yıldırım M, et al. Brain Dev. 2021 Apr;43(4):571-575. doi: 10.1016/j.braindev.2020.12.005. Epub 2020 Dec 24. Brain Dev. 2021. PMID: 33358637
BACKGROUND: Status dystonicus is an underdiagnosed condition, probably due to heterogeneous etiology, presentation and course. Herein, we report the first case of CLN8 disease in the literature presenting with status dystonicus who responded well to pharmacological interve …
BACKGROUND: Status dystonicus is an underdiagnosed condition, probably due to heterogeneous etiology, presentation and course. Herein
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