Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma.
Barbaraci C, Giurdanella G, Leotta CG, Longo A, Amata E, Dichiara M, Pasquinucci L, Turnaturi R, Prezzavento O, Cacciatore I, Zuccarello E, Lupo G, Pitari GM, Anfuso CD, Marrazzo A.
Barbaraci C, et al.
J Med Chem. 2021 Sep 23;64(18):13622-13632. doi: 10.1021/acs.jmedchem.1c00995. Epub 2021 Sep 3.
J Med Chem. 2021.
PMID: 34477381
Free PMC article.
Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults. ()-MRJF22, a prodrug of the sigma (sigma) ligand haloperidol metabolite II conju …
Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma …