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Showing results for hepatic na tc
Your search for heparin-na-at retrieved no results
Inhibition of the Hepatic Uptake of (99m)Tc-Tetrofosmin Using an Organic Cation Transporter Blocker.
Nishi K, Kobayashi M, Kikuchi M, Mizutani A, Muranaka Y, Tamai I, Kawai K, Kudo T. Nishi K, et al. Pharmaceutics. 2021 Jul 13;13(7):1073. doi: 10.3390/pharmaceutics13071073. Pharmaceutics. 2021. PMID: 34371764 Free PMC article.
The present study investigated the transport mechanisms of (99m)Tc-TF and attempted to apply competitive inhibition using a specific inhibitor to reduce (99m)Tc-TF hepatic accumulation. ...The hepatic accumulation of (99m)Tc-TF was markedly supp …
The present study investigated the transport mechanisms of (99m)Tc-TF and attempted to apply competitive inhibition using a specific …
Prolactin increases mRNA encoding Na(+)-TC cotransport polypeptide and hepatic Na(+)-TC cotransport.
Liu Y, Ganguly T, Hyde JF, Vore M. Liu Y, et al. Am J Physiol. 1995 Jan;268(1 Pt 1):G11-7. doi: 10.1152/ajpgi.1995.268.1.G11. Am J Physiol. 1995. PMID: 7840192
The present studies were designed to determine if treatment of Ovx rats with oPrl (100, 300, or 600 micrograms/day, 7 days iv) 1) increases Na(+)-TC cotransport in basolateral plasma membrane vesicles (bLPM), 2) induces a corresponding increase in the steady-state l …
The present studies were designed to determine if treatment of Ovx rats with oPrl (100, 300, or 600 micrograms/day, 7 days iv) 1) increases …
Cannabinoids and Chronic Liver Diseases.
Mboumba Bouassa RS, Sebastiani G, Di Marzo V, Jenabian MA, Costiniuk CT. Mboumba Bouassa RS, et al. Int J Mol Sci. 2022 Aug 20;23(16):9423. doi: 10.3390/ijms23169423. Int J Mol Sci. 2022. PMID: 36012687 Free PMC article. Review.
Although their etiologies differ, these CLDs all have in common a significant dysregulation of liver metabolism that is closely linked to the perturbation of the hepatic endocannabinoid system (eCBS) and inflammatory pathways. Therefore, targeting the hepatic eCBS m …
Although their etiologies differ, these CLDs all have in common a significant dysregulation of liver metabolism that is closely linked to th …
Role of protein phosphatases in cyclic AMP-mediated stimulation of hepatic Na+/taurocholate cotransport.
Mukhopadhyay S, Webster CR, Anwer MS. Mukhopadhyay S, et al. J Biol Chem. 1998 Nov 6;273(45):30039-45. doi: 10.1074/jbc.273.45.30039. J Biol Chem. 1998. PMID: 9792726 Free article.
Cyclic AMP has been proposed to stimulate Na+/taurocholate (TC) cotransport in hepatocytes by translocating Na+/TC cotransport polypeptide (Ntcp) to the plasma membrane and to induce Ntcp dephosphorylation. Whether protein phosphatases 1 and 2A (PP1/2A …
Cyclic AMP has been proposed to stimulate Na+/taurocholate (TC) cotransport in hepatocytes by translocating Na+/TC
Role of intracellular calcium and protein kinases in the activation of hepatic Na+/taurocholate cotransport by cyclic AMP.
Grüne S, Engelking LR, Anwer MS. Grüne S, et al. J Biol Chem. 1993 Aug 25;268(24):17734-41. J Biol Chem. 1993. PMID: 8394349 Free article.
Bt2cAMP, forskolin, and 8-bromo-cAMP stimulated Na(+)-dependent, but not Na(+)-independent TC uptake. Bt2cAMP increased the maximal rate of Na+/TC cotransport without affecting the apparent Km. ...Unlike thapsigargin, vasopressin inhibited Bt2cA …
Bt2cAMP, forskolin, and 8-bromo-cAMP stimulated Na(+)-dependent, but not Na(+)-independent TC uptake. Bt2cAMP increased …
Comparison of protective effects of hesperetin and pectolinarigenin on high-fat diet-induced hyperlipidemia and hepatic steatosis in Golden Syrian hamsters.
Shi L, Zou M, Zhou X, Wang S, Meng W, Lan Z. Shi L, et al. Exp Anim. 2023 Feb 21;72(1):123-131. doi: 10.1538/expanim.22-0115. Epub 2022 Oct 31. Exp Anim. 2023. PMID: 36310057 Free PMC article.
It was found that pectolinarigenin treatment resulted in significant reductions in body weight, adiposity index, serum levels of TC, TG and hepatic TC, TG and free fatty acid compared to those in control hamsters with hyperlipidemia (P<0.05). However, hesp …
It was found that pectolinarigenin treatment resulted in significant reductions in body weight, adiposity index, serum levels of TC, …
Evaluation of pharmacogenomics and hepatic nuclear imaging-related covariates by population pharmacokinetic models of irinotecan and its metabolites.
Liu Z, Martin JH, Liauw W, McLachlan SA, Link E, Matera A, Thompson M, Jefford M, Hicks RJ, Cullinane C, Hatzimihalis A, Campbell I, Crowley S, Beale PJ, Karapetis CS, Price T, Burge ME, Michael M. Liu Z, et al. Eur J Clin Pharmacol. 2022 Jan;78(1):53-64. doi: 10.1007/s00228-021-03206-w. Epub 2021 Sep 4. Eur J Clin Pharmacol. 2022. PMID: 34480602
BACKGROUND: Body surface area (BSA)-based dosing of irinotecan (IR) does not account for its pharmacokinetic (PK) and pharmacodynamic (PD) variabilities. Functional hepatic nuclear imaging (HNI) and excretory/metabolic/PD pharmacogenomics have shown correlations with IR di …
BACKGROUND: Body surface area (BSA)-based dosing of irinotecan (IR) does not account for its pharmacokinetic (PK) and pharmacodynamic (PD) v …
Beneficial Effect of Cuban Policosanol on Blood Pressure and Serum Lipoproteins Accompanied with Lowered Glycated Hemoglobin and Enhanced High-Density Lipoprotein Functionalities in a Randomized, Placebo-Controlled, and Double-Blinded Trial with Healthy Japanese.
Cho KH, Nam HS, Baek SH, Kang DJ, Na H, Komatsu T, Uehara Y. Cho KH, et al. Int J Mol Sci. 2023 Mar 8;24(6):5185. doi: 10.3390/ijms24065185. Int J Mol Sci. 2023. PMID: 36982259 Free PMC article. Clinical Trial.

The policosanol group showed significantly higher HDL-C level and HDL-C/TC (%), approximately 9.5% (p < 0.001) and 7.2% (p = 0.003), respectively, than the placebo group and a difference in the point of time and group interaction (p < 0.001). ...In conclusion, 12 wee

The policosanol group showed significantly higher HDL-C level and HDL-C/TC (%), approximately 9.5% (p < 0.001) and 7.2% (p = 0.003

99mTc(CO)3-nitrilotriacetic acid: a new renal radiopharmaceutical showing pharmacokinetic properties in rats comparable to those of 131I-OIH.
Lipowska M, Marzilli LG, Taylor AT. Lipowska M, et al. J Nucl Med. 2009 Mar;50(3):454-60. doi: 10.2967/jnumed.108.058768. Epub 2009 Feb 17. J Nucl Med. 2009. PMID: 19223406 Free PMC article.
The plasma clearances of Na(2)[(99m)Tc(CO)(3)(NTA)] and (131)I-OIH were comparable, but the extraction fraction of Na(2)[(99m)Tc(CO)(3)(NTA)] was 93.5% +/- 3.8%, compared with 67.9% +/- 6.1% for (131)I-OIH. Plasma protein binding of Na(2)[(99m) …
The plasma clearances of Na(2)[(99m)Tc(CO)(3)(NTA)] and (131)I-OIH were comparable, but the extraction fraction of Na(2 …
Di(2-ethylhexyl) phthalate disturbs cholesterol metabolism through oxidative stress in rat liver.
Li G, Zhao CY, Wu Q, Kang Z, Zhang JT, Guan SY, Jin HW, Zhang YB, Na XL. Li G, et al. Environ Toxicol Pharmacol. 2022 Oct;95:103958. doi: 10.1016/j.etap.2022.103958. Epub 2022 Aug 13. Environ Toxicol Pharmacol. 2022. PMID: 35970509
An RNA-Seq analysis was performed to describe the hepatic responses to long-term DEHP exposure in combination with serological and oxidative stress parameter measurements. DEHP increased the serum levels of total cholesterol (TC), high-density lipoprotein (HDL), and …
An RNA-Seq analysis was performed to describe the hepatic responses to long-term DEHP exposure in combination with serological and ox …
61 results