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Page 1
Completing genome replication outside of S phase.
Bhowmick R, Hickson ID, Liu Y. Bhowmick R, et al. Among authors: hickson id. Mol Cell. 2023 Oct 19;83(20):3596-3607. doi: 10.1016/j.molcel.2023.08.023. Epub 2023 Sep 15. Mol Cell. 2023. PMID: 37716351 Free article. Review.
Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during mitosis. ...In this review, we introduce the causes of RS, regions of the human genome known to be especially vulnerable to RS, and the strategies used to complete DNA replication outsid …
Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during mitosis. ...In this review, we introduce the c …
Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci.
Garribba L, Wu W, Özer Ö, Bhowmick R, Hickson ID, Liu Y. Garribba L, et al. Among authors: hickson id. Methods Enzymol. 2018;601:45-58. doi: 10.1016/bs.mie.2017.11.025. Epub 2018 Feb 3. Methods Enzymol. 2018. PMID: 29523241 Review.
Nevertheless, it is still not clear which loci that can undergo MiDAS, whether MiDAS is associated with mutations or genome rearrangements, or whether MiDAS really is a form of BIR. ...In addition, we have included methods for combining MiDAS detection …
Nevertheless, it is still not clear which loci that can undergo MiDAS, whether MiDAS is associated with mutations or genome re …
Pathways for maintenance of telomeres and common fragile sites during DNA replication stress.
Özer Ö, Hickson ID. Özer Ö, et al. Among authors: hickson id. Open Biol. 2018 Apr;8(4):180018. doi: 10.1098/rsob.180018. Open Biol. 2018. PMID: 29695617 Free PMC article. Review.
If MiDAS fails, the ensuing mitotic errors threaten genome integrity and cell viability. Recent studies have provided an insight into how MiDAS helps cells to counteract DNA replication stress. However, our understanding of the molecular mechanisms and regulation of …
If MiDAS fails, the ensuing mitotic errors threaten genome integrity and cell viability. Recent studies have provided an insight into …
Potential biomarkers of DNA replication stress in cancer.
Ren L, Chen L, Wu W, Garribba L, Tian H, Liu Z, Vogel I, Li C, Hickson ID, Liu Y. Ren L, et al. Among authors: hickson id. Oncotarget. 2017 Jun 6;8(23):36996-37008. doi: 10.18632/oncotarget.16940. Oncotarget. 2017. PMID: 28445142 Free PMC article. Review.
RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.
Bhowmick R, Minocherhomji S, Hickson ID. Bhowmick R, et al. Among authors: hickson id. Mol Cell. 2016 Dec 15;64(6):1117-1126. doi: 10.1016/j.molcel.2016.10.037. Mol Cell. 2016. PMID: 27984745 Free article.
Here, we examine the contribution of HR factors in promoting MiDAS in human cells. We report that RAD51 and BRCA2 are dispensable for MiDAS but are required to counteract replication stress at CFS loci during S-phase. ...Our results provide further mechanistic insig …
Here, we examine the contribution of HR factors in promoting MiDAS in human cells. We report that RAD51 and BRCA2 are dispensable for …
High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing.
Macheret M, Bhowmick R, Sobkowiak K, Padayachy L, Mailler J, Hickson ID, Halazonetis TD. Macheret M, et al. Among authors: hickson id. Cell Res. 2020 Nov;30(11):997-1008. doi: 10.1038/s41422-020-0358-x. Epub 2020 Jun 19. Cell Res. 2020. PMID: 32561860 Free PMC article.
Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we mapped, at high resolution, the genomic sites of MiDAS in cells treated with the DNA p …
Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of …
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome.
Wu W, Bhowmick R, Vogel I, Özer Ö, Ghisays F, Thakur RS, Sanchez de Leon E, Richter PH, Ren L, Petrini JH, Hickson ID, Liu Y. Wu W, et al. Among authors: hickson id. Nat Struct Mol Biol. 2020 May;27(5):424-437. doi: 10.1038/s41594-020-0408-6. Epub 2020 May 11. Nat Struct Mol Biol. 2020. PMID: 32398827
In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in a process known as 'MiDAS'. Here, we demonstrate that RTEL1 (regulator of telome …
In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and s …
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication.
Sonneville R, Bhowmick R, Hoffmann S, Mailand N, Hickson ID, Labib K. Sonneville R, et al. Among authors: hickson id. Elife. 2019 Sep 23;8:e48686. doi: 10.7554/eLife.48686. Elife. 2019. PMID: 31545170 Free PMC article.
These regions are processed in early mitosis via a process known as mitotic DNA repair synthesis (MiDAS), but little is known about how cells switch from conventional DNA replication to MiDAS. Using the early embryo of the nematode Caenorhabditis elegans as a model …
These regions are processed in early mitosis via a process known as mitotic DNA repair synthesis (MiDAS), but little is known about h …
Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.
Garribba L, Bjerregaard VA, Gonçalves Dinis MM, Özer Ö, Wu W, Sakellariou D, Pena-Diaz J, Hickson ID, Liu Y. Garribba L, et al. Among authors: hickson id. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16527-16536. doi: 10.1073/pnas.1921219117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601218 Free PMC article.
Here, we demonstrate that MiDAS does occur at FRAXA following folate deprivation but proceeds via a pathway that shows some mechanistic differences from that at CFSs, being dependent on RAD51, SLX1, and POLD3. A failure to complete MiDAS at FRAXA leads to severe loc …
Here, we demonstrate that MiDAS does occur at FRAXA following folate deprivation but proceeds via a pathway that shows some mechanist …
11 results