RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome.
Wu W, Bhowmick R, Vogel I, Özer Ö, Ghisays F, Thakur RS, Sanchez de Leon E, Richter PH, Ren L, Petrini JH, Hickson ID, Liu Y.
Wu W, et al. Among authors: hickson id.
Nat Struct Mol Biol. 2020 May;27(5):424-437. doi: 10.1038/s41594-020-0408-6. Epub 2020 May 11.
Nat Struct Mol Biol. 2020.
PMID: 32398827
In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in a process known as 'MiDAS'. Here, we demonstrate that RTEL1 (regulator of telome …
In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and s …