Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1991 1
1992 1
1995 1
1996 1
1998 1
1999 1
2002 2
2003 1
2006 2
2012 1
2021 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

14 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Horse chestnut seed extract for chronic venous insufficiency.
Pittler MH, Ernst E. Pittler MH, et al. Cochrane Database Syst Rev. 2012 Nov 14;11(11):CD003230. doi: 10.1002/14651858.CD003230.pub4. Cochrane Database Syst Rev. 2012. PMID: 23152216 Free PMC article. Review.
This is an update of a Cochrane review first published in 2002 and updated in 2004, 2006, 2008 and 2010. OBJECTIVES: To review the efficacy and safety of oral horse chestnut seed extract (HCSE) versus placebo, or reference therapy, for the treatment of CVI. . …
This is an update of a Cochrane review first published in 2002 and updated in 2004, 2006, 2008 and 2010. OBJECTIVES: To review the efficacy …
Horse chestnut seed extract for chronic venous insufficiency.
Pittler MH, Ernst E. Pittler MH, et al. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD003230. doi: 10.1002/14651858.CD003230.pub3. Cochrane Database Syst Rev. 2006. PMID: 16437450 Updated. Review.
Therefore, oral drug treatment is an attractive option. OBJECTIVES: To review the efficacy and safety of oral horse chestnut seed extract (HCSE) versus placebo, or reference therapy, for the treatment of CVI. ...
Therefore, oral drug treatment is an attractive option. OBJECTIVES: To review the efficacy and safety of oral horse chestnut …
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease.
Pompilio G, Nicolaides A, Kakkos SK, Integlia D. Pompilio G, et al. Phlebology. 2021 Oct;36(9):695-709. doi: 10.1177/02683555211015020. Epub 2021 May 13. Phlebology. 2021. PMID: 33983078
OBJECTIVE: To assess the clinical efficacy of sulodexide, including a comparison with venoactive drugs (VAD) (micronized purified flavonoid fraction, MPFF; hydroxy-ethyl-rutosides, HR; calcium dobesilate;Ruscus extract combined with hesperidin methyl chalcone and vitamin C, Ruscu …
OBJECTIVE: To assess the clinical efficacy of sulodexide, including a comparison with venoactive drugs (VAD) (micronized purified flavonoid …
Herbal medications for common ailments in the elderly.
Ernst E. Ernst E. Drugs Aging. 1999 Dec;15(6):423-8. doi: 10.2165/00002512-199915060-00002. Drugs Aging. 1999. PMID: 10641953
There is relatively compelling evidence that Ginkgo biloba (ginkgo) is effective in delaying the clinical course of dementias. It has been well documented that Aesculus hippocastanum (horse chestnut) seed extracts alleviate the subjective symptoms and reduce …
There is relatively compelling evidence that Ginkgo biloba (ginkgo) is effective in delaying the clinical course of dementias. It has been w …
Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency.
Koch R. Koch R. Phytother Res. 2002 Mar;16 Suppl 1:S1-5. doi: 10.1002/ptr.1010. Phytother Res. 2002. PMID: 11933130 Clinical Trial.
The aim of this study was to compare the efficacy of Venostasin (horse chestnut seed extract) and Pycnogenol (French maritime pine bark extract) in the treatment of chronic venous insufficiency (CVI). ...
The aim of this study was to compare the efficacy of Venostasin (horse chestnut seed extract) and Pycnogenol (French ma …
Bioavailability of beta-aescin from horse chestnut seed extract: comparative clinical studies of two Galenic formulations.
Bässler D, Okpanyi S, Schrödter A, Loew D, Schürer M, Schulz HU. Bässler D, et al. Adv Ther. 2003 Sep-Oct;20(5):295-304. doi: 10.1007/BF02849858. Adv Ther. 2003. PMID: 14964349 Clinical Trial.
The bioavailability of beta-aescin--the main active constituent of horse chestnut seed extract--in a nonretarded test medication in comparison with that in a retarded reference formulation was evaluated in 2 randomized crossover clinical trials involving 18 h …
The bioavailability of beta-aescin--the main active constituent of horse chestnut seed extract--in a nonretarded test m …
Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies.
Suter A, Bommer S, Rechner J. Suter A, et al. Adv Ther. 2006 Jan-Feb;23(1):179-90. doi: 10.1007/BF02850359. Adv Ther. 2006. PMID: 16644618
Extracts from the seed of the horse chestnut (Aesculus hippocastanum L.) have traditionally been used to treat patients with chronic venous insufficiency and to alleviate its associated symptoms, including lower leg swelling. The efficacy of preparations that contain horse …
Extracts from the seed of the horse chestnut (Aesculus hippocastanum L.) have traditionally been used to treat patients with chronic venous …
[Effects of horse-chestnut seed extract on transcapillary filtration in chronic venous insufficiency].
Bisler H, Pfeifer R, Klüken N, Pauschinger P. Bisler H, et al. Dtsch Med Wochenschr. 1986 Aug 29;111(35):1321-9. doi: 10.1055/s-2008-1068628. Dtsch Med Wochenschr. 1986. PMID: 3527643 Clinical Trial. German.
The effect of horse-chestnut seed extract (standardized on aescin; Venostasin retard) was assessed in a randomized placebo-controlled crossover double-blind trial of 22 patients with proven chronic venous insufficiency by measuring the capillary filtration co …
The effect of horse-chestnut seed extract (standardized on aescin; Venostasin retard) was assessed in a randomized plac …
Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency.
Diehm C, Trampisch HJ, Lange S, Schmidt C. Diehm C, et al. Lancet. 1996 Feb 3;347(8997):292-4. doi: 10.1016/s0140-6736(96)90467-5. Lancet. 1996. PMID: 8569363 Clinical Trial.
This study was carried out to compare the efficacy (oedema reduction) and safety of compression stockings class II and dried horse chestnut seed extract (HCSE, 50 mg aescin, twice daily). METHODS: Equivalence of both therapies was examined in a novel hierarch …
This study was carried out to compare the efficacy (oedema reduction) and safety of compression stockings class II and dried horse …
Medical edema protection--clinical benefit in patients with chronic deep vein incompetence. A placebo controlled double blind study.
Diehm C, Vollbrecht D, Amendt K, Comberg HU. Diehm C, et al. Vasa. 1992;21(2):188-92. Vasa. 1992. PMID: 1621440 Clinical Trial.
In a randomized placebo controlled parallel double blind study on 40 patients suffering from venous edema in chronic deep vein incompetence, the edema-reducing effect of horse chestnut seed extract vs. placebo, being the main test variable, was demonstrated b …
In a randomized placebo controlled parallel double blind study on 40 patients suffering from venous edema in chronic deep vein incompetence, …
14 results