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Down-regulation of hsa-miR-1264 contributes to DNMT1-mediated silencing of SOCS3.
Boosani CS, Dhar K, Agrawal DK. Boosani CS, et al. Mol Biol Rep. 2015 Sep;42(9):1365-76. doi: 10.1007/s11033-015-3882-x. Mol Biol Rep. 2015. PMID: 26047583 Free PMC article.
Our miRNA expression profiling revealed profound down-regulation of two specific miRNAs, hsa-miR-758 and hsa-miR-1264, whose expression levels were decreased by 8-10 folds in HCASMCs that were treated with both TNF-alpha and IGF-1. ...Expression of hsa …
Our miRNA expression profiling revealed profound down-regulation of two specific miRNAs, hsa-miR-758 and hsa-miR-1264, …
MiR-323b-5p acts as a novel diagnostic biomarker for critical limb ischemia in type 2 diabetic patients.
Cheng B, Li JY, Li XC, Wang XF, Wang ZJ, Liu J, Deng AP. Cheng B, et al. Sci Rep. 2018 Oct 10;8(1):15080. doi: 10.1038/s41598-018-33310-4. Sci Rep. 2018. PMID: 30305681 Free PMC article.
We statistically identified 7 miRNAs (hsa-miR-200b-3p, hsa-miR-2115-3p, hsa-miR-431-5p, hsa-miR-486-5p, hsa-miR-210-3p, hsa-miR-1264, hsa-miR-323b-5p) which were up-regulated in the CLI group, whereas other 4 miRNAs (hsa-miR-5579-3p, hsa-miR-665, hsa-miR-4285 …
We statistically identified 7 miRNAs (hsa-miR-200b-3p, hsa-miR-2115-3p, hsa-miR-431-5p, hsa-miR-486-5p, hsa-miR-210-3p, hsa-miR …
Five miRNAs considered as molecular targets for predicting neuroglioma.
Yang H, Wang Y. Yang H, et al. Tumour Biol. 2016 Jan;37(1):1051-9. doi: 10.1007/s13277-015-3898-9. Epub 2015 Aug 14. Tumour Biol. 2016. PMID: 26269115
A total of 33 DEMs were obtained, among which 25 miRNAs were upregulated including hsa-mir-675, hsa-mir-196a-1, and hsa-mir-196a-2, while eight miRNAs were downregulated including hsa-mir-1911, hsa-mir-1264, and hsa-mir-1298. Five miRNAs with diagnostic and p …
A total of 33 DEMs were obtained, among which 25 miRNAs were upregulated including hsa-mir-675, hsa-mir-196a-1, and hsa-mir-196a-2, while ei …
Differential expression of miRNAs in a human developing neuronal cell line chronically infected with Zika virus.
Bagasra O, Shamabadi NS, Pandey P, Desoky A, McLean E. Bagasra O, et al. Libyan J Med. 2021 Dec;16(1):1909902. doi: 10.1080/19932820.2021.1909902. Libyan J Med. 2021. PMID: 33849406 Free PMC article.
In particular, we determined that hsa-mir-431-5p, hsa-mir-3687, hsa-mir-4655-5p, hsa-mir-6071, hsa-mir-762, hsa-mir-5787, and hsa-mir-6825-3p were significantly downregulated, ranging from -5711 to -660-fold whereas, has-mir-4315, hsa-mir-5681b, hsa-mir-6511a-3p, hsa-mi …
In particular, we determined that hsa-mir-431-5p, hsa-mir-3687, hsa-mir-4655-5p, hsa-mir-6071, hsa-mir-762, hsa-mir-5787, and hsa-mir-6825-3 …
The genomic landscape associated with resistance to aromatase inhibitors in breast cancer.
Sadasivam K, Manoharan JP, Palanisamy H, Vidyalakshmi S. Sadasivam K, et al. Genomics Inform. 2023 Jun;21(2):e20. doi: 10.5808/gi.23012. Epub 2023 Jun 30. Genomics Inform. 2023. PMID: 37415453 Free PMC article.
The top mutated genes (FGFR3, CDKN2A, RNF208, MAPK4, MAPK15, HSD3B1, CRYBB2, CDC20B, TP53TG5, and MAPK8IP3) were predicted. We also identified a key miRNA - hsa-mir-1264 regulating the expression of CDC20B. Pathway analysis revealed HSD3B1 to be involved in e …
The top mutated genes (FGFR3, CDKN2A, RNF208, MAPK4, MAPK15, HSD3B1, CRYBB2, CDC20B, TP53TG5, and MAPK8IP3) were predicted. We also identifi …
Inhibition of DNA methyltransferase-1 instigates the expression of DNA methyltransferase-3a in angioplasty-induced restenosis.
Boosani CS, Gunasekar P, Block M, Jiang W, Zhang Z, Radwan MM, Agrawal DK. Boosani CS, et al. Can J Physiol Pharmacol. 2018 Oct;96(10):1030-1039. doi: 10.1139/cjpp-2018-0111. Epub 2018 Aug 1. Can J Physiol Pharmacol. 2018. PMID: 30067080
Here, we studied the molecular mechanisms that occur during angioplasty-induced restenosis and found that DNMT1 inhibition in both in vitro and in vivo approaches resulted in the induction of DNA methyltransferase-3a (DNMT3a) expression. In vascular smooth muscle cells (VSMCs), t …
Here, we studied the molecular mechanisms that occur during angioplasty-induced restenosis and found that DNMT1 inhibition in both in vitro …