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1,995 results

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Page 1
Lysine Hydroxylation and Cross-Linking of Collagen.
Yamauchi M, Terajima M, Shiiba M. Yamauchi M, et al. Methods Mol Biol. 2019;1934:309-324. doi: 10.1007/978-1-4939-9055-9_19. Methods Mol Biol. 2019. PMID: 31256387
Collagens represent a large family of structurally related proteins containing a unique triple-helical structure. ...This chapter presents an overview of lysine hydroxylation and cross-linking of collagen, and the analytical methods we have developed....
Collagens represent a large family of structurally related proteins containing a unique triple-helical structure. ...This chapter pre …
[Industrial development and biomedical application prospect of recombinant collagen].
Fu R, Fan D, Yang W, Chen L, Qu C, Yang S, Xu L. Fu R, et al. Sheng Wu Gong Cheng Xue Bao. 2022 Sep 25;38(9):3228-3242. doi: 10.13345/j.cjb.220061. Sheng Wu Gong Cheng Xue Bao. 2022. PMID: 36151795 Free article. Review. Chinese.
Recombinant collagen, as an alternative to natural collagen, has the potential to be widely used in biomaterials, biomedicine, etc. ...In particularly, we focused on the current progress in the recombinant collagen production, including recombinant expression …
Recombinant collagen, as an alternative to natural collagen, has the potential to be widely used in biomaterials, biomedicine, …
Contrasting Local and Macroscopic Effects of Collagen Hydroxylation.
Varma S, Orgel JPRO, Schieber JD. Varma S, et al. Int J Mol Sci. 2021 Aug 23;22(16):9068. doi: 10.3390/ijms22169068. Int J Mol Sci. 2021. PMID: 34445791 Free PMC article.
Collagen is heavily hydroxylated. Experiments show that proline hydroxylation is important to triple helix (monomer) stability, fibril assembly, and interaction of fibrils with other molecules. ...Our simulations reproduce the experimental observation that …
Collagen is heavily hydroxylated. Experiments show that proline hydroxylation is important to triple helix (monomer) st …
Collagen type II-hyaluronan interactions - the effect of proline hydroxylation: a molecular dynamics study.
Bełdowski P, Przybyłek M, Bełdowski D, Dedinaite A, Sionkowska A, Cysewski P, Claesson PM. Bełdowski P, et al. J Mater Chem B. 2022 Nov 30;10(46):9713-9723. doi: 10.1039/d2tb01550a. J Mater Chem B. 2022. PMID: 36413305
This article presents the results from molecular dynamics calculations of HA-collagen type II interactions with hyaluronan. The applied protocol employed docking and geometry optimization of complexes built using collagen structures with different numbers of hydr …
This article presents the results from molecular dynamics calculations of HA-collagen type II interactions with hyaluronan. The appli …
Investigation of Triple-Helix Collagen Hydroxylation by Solid-State NMR Spectroscopy.
Chow WY. Chow WY. Methods Mol Biol. 2019;1944:57-77. doi: 10.1007/978-1-4939-9095-5_5. Methods Mol Biol. 2019. PMID: 30840235
Solid-state nuclear magnetic resonance spectroscopy (ssNMR) is an emerging technique in structural methods of studying collagen proteins, capable of identifying features on an atomic length scale in tissues and protein samples without extensive extraction or purification. …
Solid-state nuclear magnetic resonance spectroscopy (ssNMR) is an emerging technique in structural methods of studying collagen prote …
Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation.
Chen G, Tang Q, Yu S, Shen Y, Sun J, Peng J, Yin Y, Feng G, Lu X, Mei G, Zhang Y, Wan Q, Zhang L, Chen L. Chen G, et al. Cell Death Differ. 2023 Jun;30(6):1503-1516. doi: 10.1038/s41418-023-01152-x. Epub 2023 Apr 7. Cell Death Differ. 2023. PMID: 37029304 Free PMC article.
Excessive LAN exposure induces downregulation of the core circadian clock protein BMAL1, which leads to collagen accumulation in the ER. Further investigations suggest that BMAL1 is the direct transcriptional activator of prolyl 4-hydroxylase subunit alpha 1 (P4ha1) in cho …
Excessive LAN exposure induces downregulation of the core circadian clock protein BMAL1, which leads to collagen accumulation in the …
Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy.
Peterkofsky B. Peterkofsky B. Am J Clin Nutr. 1991 Dec;54(6 Suppl):1135S-1140S. doi: 10.1093/ajcn/54.6.1135s. Am J Clin Nutr. 1991. PMID: 1720597 Review.
Vitamin C deficiency is associated with defective connective tissue, particularly in wound healing. Ascorbate is required for hydroxylation of proline residues in procollagen and hydroxyproline stabilizes the collagen triple helical structure. Consequently, ascorbat …
Vitamin C deficiency is associated with defective connective tissue, particularly in wound healing. Ascorbate is required for hydroxylati …
Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues.
Homan EP, Lietman C, Grafe I, Lennington J, Morello R, Napierala D, Jiang MM, Munivez EM, Dawson B, Bertin TK, Chen Y, Lua R, Lichtarge O, Hicks J, Weis MA, Eyre D, Lee BH. Homan EP, et al. PLoS Genet. 2014 Jan;10(1):e1004121. doi: 10.1371/journal.pgen.1004121. Epub 2014 Jan 23. PLoS Genet. 2014. PMID: 24465224 Free PMC article.
Recent data suggest that prolyl 3-hydroxylation of Pro986 is not required for the structural stability of collagen; however, the absence of this post-translational modification may disrupt protein-protein interactions integral for proper collagen folding and …
Recent data suggest that prolyl 3-hydroxylation of Pro986 is not required for the structural stability of collagen; however, t …
Role of prolyl hydroxylation in the molecular interactions of collagens.
Rappu P, Salo AM, Myllyharju J, Heino J. Rappu P, et al. Essays Biochem. 2019 Sep 13;63(3):325-335. doi: 10.1042/EBC20180053. Print 2019 Sep 13. Essays Biochem. 2019. PMID: 31350381 Free PMC article. Review.
Co- and post-translational hydroxylation of proline residues is critical for the stability of the triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4-hydroxylases and collagen prolyl 3-hydroxylases, the enzy …
Co- and post-translational hydroxylation of proline residues is critical for the stability of the triple helical collagen stru …
Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia.
Cabral WA, Fratzl-Zelman N, Weis M, Perosky JE, Alimasa A, Harris R, Kang H, Makareeva E, Barnes AM, Roschger P, Leikin S, Klaushofer K, Forlino A, Backlund PS, Eyre DR, Kozloff KM, Marini JC. Cabral WA, et al. Matrix Biol. 2020 Aug;90:20-39. doi: 10.1016/j.matbio.2020.02.003. Epub 2020 Feb 26. Matrix Biol. 2020. PMID: 32112888 Free PMC article.
Lack of either protein prevents formation of the ER prolyl 3-hydroxylation complex, which catalyzes 3Hyp modification of types I and II collagen and also acts as a collagen chaperone. ...Thus, 3-hydroxylation of the A1 site alpha1(I)P986 affects col …
Lack of either protein prevents formation of the ER prolyl 3-hydroxylation complex, which catalyzes 3Hyp modification of types I and …
1,995 results