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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1977 1
1980 1
1990 1
1993 3
1996 5
1997 3
1998 1
1999 3
2000 2
2001 6
2002 10
2003 9
2004 2
2005 5
2006 16
2007 18
2008 7
2009 9
2010 13
2011 24
2012 24
2013 18
2014 21
2015 24
2016 23
2017 18
2018 21
2019 18
2020 21
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2023 22
2024 9

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361 results

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Page 1
Nebulised hypertonic saline for cystic fibrosis.
Wark P, McDonald VM, Smith S. Wark P, et al. Cochrane Database Syst Rev. 2023 Jun 14;6(6):CD001506. doi: 10.1002/14651858.CD001506.pub5. Cochrane Database Syst Rev. 2023. PMID: 37319354 Review.
OBJECTIVES: To investigate efficacy and tolerability of nebulised hypertonic saline treatment in people with cystic fibrosis (CF) compared to placebo or other treatments that enhance mucociliary clearance. ...Hypertonic saline versus cont …
OBJECTIVES: To investigate efficacy and tolerability of nebulised hypertonic saline treatment in people with cystic …
Cystic fibrosis.
O'Sullivan BP, Freedman SD. O'Sullivan BP, et al. Lancet. 2009 May 30;373(9678):1891-904. doi: 10.1016/S0140-6736(09)60327-5. Epub 2009 May 4. Lancet. 2009. PMID: 19403164 Review.
Cystic fibrosis is the most common lethal genetic disease in white populations. ...One of these treatments, hypertonic saline, is already in use, whereas others are in advanced stages of development. ...
Cystic fibrosis is the most common lethal genetic disease in white populations. ...One of these treatments, hypertonic …
Nebulised hypertonic saline for cystic fibrosis.
Wark P, McDonald VM. Wark P, et al. Cochrane Database Syst Rev. 2018 Sep 27;9(9):CD001506. doi: 10.1002/14651858.CD001506.pub4. Cochrane Database Syst Rev. 2018. PMID: 30260472 Free PMC article. Updated. Review.
BACKGROUND: Impaired mucociliary clearance characterises lung disease in cystic fibrosis (CF). Hypertonic saline enhances mucociliary clearance and may lessen the destructive inflammatory process in the airways. ...SEARCH METHODS: We searched the Cochr …
BACKGROUND: Impaired mucociliary clearance characterises lung disease in cystic fibrosis (CF). Hypertonic saline …
Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials.
Mayer-Hamblett N, Ratjen F, Russell R, Donaldson SH, Riekert KA, Sawicki GS, Odem-Davis K, Young JK, Rosenbluth D, Taylor-Cousar JL, Goss CH, Retsch-Bogart G, Clancy JP, Genatossio A, O'Sullivan BP, Berlinski A, Millard SL, Omlor G, Wyatt CA, Moffett K, Nichols DP, Gifford AH; SIMPLIFY Study Group. Mayer-Hamblett N, et al. Lancet Respir Med. 2023 Apr;11(4):329-340. doi: 10.1016/S2213-2600(22)00434-9. Epub 2022 Nov 4. Lancet Respir Med. 2023. PMID: 36343646 Free PMC article. Clinical Trial.
METHODS: The SIMPLIFY study included two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials at 80 participating clinics across the USA in the Cystic Fibrosis Therapeutics Development Network. We included individuals with cystic …
METHODS: The SIMPLIFY study included two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials at 80 participati …
Timing of hypertonic saline inhalation for cystic fibrosis.
Elkins M, Dentice R. Elkins M, et al. Cochrane Database Syst Rev. 2016 Dec;12(12):CD008816. doi: 10.1002/14651858.CD008816.pub3. Epub 2016 Dec 22. Cochrane Database Syst Rev. 2016. PMID: 28146603 Free PMC article. Updated. Review.
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. OBJECTIVES: To determine whether the timing of hypertonic saline inhala …
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical …
Cystic Fibrosis.
Savant A, Lyman B, Bojanowski C, Upadia J. Savant A, et al. 2001 Mar 26 [updated 2023 Mar 9]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2001 Mar 26 [updated 2023 Mar 9]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301428 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: Cystic fibrosis (CF) is a multisystem disease affecting epithelia of the respiratory tract, exocrine pancreas, intestine, hepatobiliary system, and exocrine sweat glands. ...DIAGNOSIS/TESTING: The diagnosis of CF is established in a proband …
CLINICAL CHARACTERISTICS: Cystic fibrosis (CF) is a multisystem disease affecting epithelia of the respiratory tract, exocrine …
Timing of hypertonic saline inhalation for cystic fibrosis.
Elkins M, Dentice R. Elkins M, et al. Cochrane Database Syst Rev. 2020 Feb 28;2(2):CD008816. doi: 10.1002/14651858.CD008816.pub4. Cochrane Database Syst Rev. 2020. PMID: 32107770 Free PMC article.
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. This is an update of a previously published Cochrane Review. OBJECTIVES: To determine …
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical …
Efficacy of hypertonic saline versus isotonic saline among children with cystic fibrosis: A systematic review and meta-analysis.
Ullah SE, Zahoor MM, Gupta S, Boparai S, Muneeb M, Eltieb SAH, Shankar A, Kidiavai HM, Vohra RR, Devi A, Bhura ZA, Aslam ZM, Shoaib M. Ullah SE, et al. Can J Respir Ther. 2023 Jan 20;59:1-7. doi: 10.29390/cjrt-2022-046. eCollection 2023. Can J Respir Ther. 2023. PMID: 36711047 Free PMC article. Review.
BACKGROUND: Inhaled hypertonic saline (HS) reduces pulmonary exacerbations in patients with cystic fibrosis (CF) aged 6 or more years. ...Trials involving only patients greater than 6 years or control group other than isotonic saline (IS) were e …
BACKGROUND: Inhaled hypertonic saline (HS) reduces pulmonary exacerbations in patients with cystic fibrosis (CF) …
Hypertonic saline for cystic fibrosis: worth its salt?
Goralski JL, Donaldson SH. Goralski JL, et al. Expert Rev Respir Med. 2014 Jun;8(3):267-9. doi: 10.1586/17476348.2014.896203. Epub 2014 Mar 26. Expert Rev Respir Med. 2014. PMID: 24666113
Airway dehydration in cystic fibrosis (CF) leads to chronic inflammation, ongoing infection and progressive lung disease. ...In this editorial, we discuss the evidence behind hypertonic saline use for adults, children and infants with CF....
Airway dehydration in cystic fibrosis (CF) leads to chronic inflammation, ongoing infection and progressive lung disease. ...I …
Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.
Reeves EP, Molloy K, Pohl K, McElvaney NG. Reeves EP, et al. ScientificWorldJournal. 2012;2012:465230. doi: 10.1100/2012/465230. Epub 2012 May 3. ScientificWorldJournal. 2012. PMID: 22645424 Free PMC article. Review.
Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been shown that hypertonic saline possesses mucolytic properties and aids mucociliary clearance by restoring the liquid layer lining th …
Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been show …
361 results