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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1917 1
1924 1
1942 1
1945 1
1946 2
1947 4
1948 1
1949 2
1950 4
1951 3
1953 6
1954 3
1955 4
1956 2
1957 3
1958 5
1959 4
1960 3
1961 8
1962 2
1963 5
1964 6
1965 2
1966 4
1967 1
1968 5
1969 9
1970 3
1971 6
1972 10
1973 21
1974 23
1975 90
1976 108
1977 92
1978 84
1979 103
1980 86
1981 81
1982 83
1983 84
1984 111
1985 115
1986 123
1987 107
1988 109
1989 162
1990 164
1991 173
1992 157
1993 146
1994 161
1995 145
1996 163
1997 152
1998 133
1999 118
2000 154
2001 144
2002 168
2003 157
2004 190
2005 206
2006 218
2007 188
2008 206
2009 188
2010 200
2011 197
2012 218
2013 195
2014 205
2015 199
2016 133
2017 165
2018 143
2019 126
2020 140
2021 125
2022 91
2023 91
2024 32

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6,897 results

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Page 1
Hypertonic saline and mannitol in patients with traumatic brain injury: A systematic and meta-analysis.
Shi J, Tan L, Ye J, Hu L. Shi J, et al. Medicine (Baltimore). 2020 Aug 28;99(35):e21655. doi: 10.1097/MD.0000000000021655. Medicine (Baltimore). 2020. PMID: 32871879 Free PMC article.
BACKGROUND: To compare the effects of 3% hypertonic saline solution and 20% mannitol solution on intracranial hypertension. METHODS: WAN-FANGDATA, CNKI, and CQVIP databases were searched, and relevant literatures of randomized controlled trials compari …
BACKGROUND: To compare the effects of 3% hypertonic saline solution and 20% mannitol solution on intracranial hy …
Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial.
Roquilly A, Moyer JD, Huet O, Lasocki S, Cohen B, Dahyot-Fizelier C, Chalard K, Seguin P, Jeantrelle C, Vermeersch V, Gaillard T, Cinotti R, Demeure Dit Latte D, Mahe PJ, Vourc'h M, Martin FP, Chopin A, Lerebourg C, Flet L, Chiffoleau A, Feuillet F, Asehnoune K; Atlanrea Study Group and the Société Française d’Anesthésie Réanimation (SFAR) Research Network. Roquilly A, et al. JAMA. 2021 May 25;325(20):2056-2066. doi: 10.1001/jama.2021.5561. JAMA. 2021. PMID: 34032829 Free PMC article. Clinical Trial.
INTERVENTIONS: Adult patients with moderate to severe traumatic brain injury were randomly assigned to receive continuous infusion of 20% hypertonic saline solution plus standard care (n = 185) or standard care alone (controls; n = 185). The 20% hypertonic
INTERVENTIONS: Adult patients with moderate to severe traumatic brain injury were randomly assigned to receive continuous infusion of 20% …
The Use of Mannitol and Hypertonic Saline Therapies in Patients with Elevated Intracranial Pressure: A Review of the Evidence.
Witherspoon B, Ashby NE. Witherspoon B, et al. Nurs Clin North Am. 2017 Jun;52(2):249-260. doi: 10.1016/j.cnur.2017.01.002. Epub 2017 Apr 7. Nurs Clin North Am. 2017. PMID: 28478873 Review.
Regardless of the cause of increased intracranial pressure, osmotherapy is considered the mainstay of medical therapy, and should be administered as soon as possible. This article reviews the history of hyperosmolar and hypertonic therapies, the Monro-Kellie hypothesis, an …
Regardless of the cause of increased intracranial pressure, osmotherapy is considered the mainstay of medical therapy, and should be adminis …
Hypertonic saline.
Hoffer A, Selman WR. Hoffer A, et al. J Neurosurg. 2012 Jan;116(1):208-9; discussion 209. doi: 10.3171/2011.6.JNS11831. Epub 2011 Sep 23. J Neurosurg. 2012. PMID: 21942726 No abstract available.
Hyponatremia in dogs and cats.
Burton AG, Hopper K. Burton AG, et al. J Vet Emerg Crit Care (San Antonio). 2019 Sep;29(5):461-471. doi: 10.1111/vec.12881. Epub 2019 Aug 26. J Vet Emerg Crit Care (San Antonio). 2019. PMID: 31448558 Review.
As a general rule, serum sodium concentration should be raised 10 mmol/L over 24 hours, but rapid increases in serum sodium are indicated if neurologic abnormalities are evident. Serum sodium can be increased using hypertonic saline, with dosing based on the patient …
As a general rule, serum sodium concentration should be raised 10 mmol/L over 24 hours, but rapid increases in serum sodium are indicated if …
Hypertonic saline.
Li YH, Yu CH, Chien TJ, Huang RC, Tan PH, Cheng YS, Chen CA, Hueng DY. Li YH, et al. J Neurosurg. 2013 Dec;119(6):1646. doi: 10.3171/2013.6.JNS131094. Epub 2013 Sep 20. J Neurosurg. 2013. PMID: 24053498 No abstract available.
Equimolar doses of hypertonic agents (saline or mannitol) in the treatment of intracranial hypertension after severe traumatic brain injury.
Huang X, Yang L, Ye J, He S, Wang B. Huang X, et al. Medicine (Baltimore). 2020 Sep 18;99(38):e22004. doi: 10.1097/MD.0000000000022004. Medicine (Baltimore). 2020. PMID: 32957318 Free PMC article. Clinical Trial.
BACKGROUND: Mannitol and hypertonic saline (HTS) are effective in reducing intracranial pressure (ICP) after severe traumatic brain injury (TBI). ...
BACKGROUND: Mannitol and hypertonic saline (HTS) are effective in reducing intracranial pressure (ICP) after severe traumatic …
Hypertonic saline.
Smith JE, Hall MJ. Smith JE, et al. J R Army Med Corps. 2004 Dec;150(4):239-43. doi: 10.1136/jramc-150-04-03. J R Army Med Corps. 2004. PMID: 15732410 Review.
The optimal fluid for the resuscitation of critically ill and injured patients remains the subject of considerable controversy. Hypertonic crystalloid solutions such as hypertonic saline provide rapid volume expansion, have an acceptable safety profile, and a …
The optimal fluid for the resuscitation of critically ill and injured patients remains the subject of considerable controversy. Hypertoni
Diagnosis and management of sodium disorders: hyponatremia and hypernatremia.
Braun MM, Barstow CH, Pyzocha NJ. Braun MM, et al. Am Fam Physician. 2015 Mar 1;91(5):299-307. Am Fam Physician. 2015. PMID: 25822386 Free article.
In general, hyponatremia is treated with fluid restriction (in the setting of euvolemia), isotonic saline (in hypovolemia), and diuresis (in hypervolemia). A combination of these therapies may be needed based on the presentation. Hypertonic saline is used to …
In general, hyponatremia is treated with fluid restriction (in the setting of euvolemia), isotonic saline (in hypovolemia), and diure …
Hypertonic saline.
Bergui M, Bradac GB. Bergui M, et al. J Neurosurg. 2008 Mar;108(3):632; author reply 632-3. doi: 10.3171/JNS/2008/108/3/0632. J Neurosurg. 2008. PMID: 18312116 No abstract available.
6,897 results