Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 1
1990 2
1991 2
1992 3
1994 1
1995 3
1996 2
1997 5
1998 1
1999 3
2000 5
2001 4
2002 1
2003 4
2004 8
2005 6
2006 13
2007 17
2008 20
2009 18
2010 15
2011 18
2012 17
2013 20
2014 24
2015 25
2016 18
2017 15
2018 20
2019 22
2020 32
2021 33
2022 27
2023 27
2024 11

Text availability

Article attribute

Article type

Publication date

Search Results

401 results

Results by year

Filters applied: . Clear all
Page 1
Hypertonic saline and mannitol in patients with traumatic brain injury: A systematic and meta-analysis.
Shi J, Tan L, Ye J, Hu L. Shi J, et al. Medicine (Baltimore). 2020 Aug 28;99(35):e21655. doi: 10.1097/MD.0000000000021655. Medicine (Baltimore). 2020. PMID: 32871879 Free PMC article.
BACKGROUND: To compare the effects of 3% hypertonic saline solution and 20% mannitol solution on intracranial hypertension. METHODS: WAN-FANGDATA, CNKI, and CQVIP databases were searched, and relevant literatures of randomized controlled trials compari …
BACKGROUND: To compare the effects of 3% hypertonic saline solution and 20% mannitol solution on intracranial hy …
Hypertonic saline for traumatic brain injury: a systematic review and meta-analysis.
Gharizadeh N, Ghojazadeh M, Naseri A, Dolati S, Tarighat F, Soleimanpour H. Gharizadeh N, et al. Eur J Med Res. 2022 Nov 20;27(1):254. doi: 10.1186/s40001-022-00897-4. Eur J Med Res. 2022. PMID: 36404350 Free PMC article.
BACKGROUND: Traumatic brain injury (TBI) causes mortality and long-term disability among young adults and imposes a notable cost on the healthcare system. In addition to the first physical hit, secondary injury, which is associated with increased intracranial pressu …
BACKGROUND: Traumatic brain injury (TBI) causes mortality and long-term disability among young adults and imposes a notable co …
Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial.
Roquilly A, Moyer JD, Huet O, Lasocki S, Cohen B, Dahyot-Fizelier C, Chalard K, Seguin P, Jeantrelle C, Vermeersch V, Gaillard T, Cinotti R, Demeure Dit Latte D, Mahe PJ, Vourc'h M, Martin FP, Chopin A, Lerebourg C, Flet L, Chiffoleau A, Feuillet F, Asehnoune K; Atlanrea Study Group and the Société Française d’Anesthésie Réanimation (SFAR) Research Network. Roquilly A, et al. JAMA. 2021 May 25;325(20):2056-2066. doi: 10.1001/jama.2021.5561. JAMA. 2021. PMID: 34032829 Free PMC article. Clinical Trial.
OBJECTIVE: To determine whether continuous infusion of hypertonic saline solution improves neurological outcome at 6 months in patients with traumatic brain injury. ...Follow-up was completed in February 2020. INTERVENTIONS: Adult patients with …
OBJECTIVE: To determine whether continuous infusion of hypertonic saline solution improves neurological outcome at 6 mo …
Hypertonic saline versus other intracranial pressure-lowering agents for people with acute traumatic brain injury.
Chen H, Song Z, Dennis JA. Chen H, et al. Cochrane Database Syst Rev. 2020 Jan 17;1(1):CD010904. doi: 10.1002/14651858.CD010904.pub3. Cochrane Database Syst Rev. 2020. PMID: 31978260 Free PMC article.
Hypertonic saline is a hyperosmolar therapy that is used in traumatic brain injury to reduce intracranial pressure. ...OBJECTIVES: To assess the comparative efficacy and safety of hypertonic saline versus other intracranial pressure-lower …
Hypertonic saline is a hyperosmolar therapy that is used in traumatic brain injury to reduce intracranial pressu …
Hypertonic Saline is Superior to Mannitol for the Combined Effect on Intracranial Pressure and Cerebral Perfusion Pressure Burdens in Patients With Severe Traumatic Brain Injury.
Mangat HS, Wu X, Gerber LM, Schwarz JT, Fakhar M, Murthy SB, Stieg PE, Ghajar J, Härtl R. Mangat HS, et al. Neurosurgery. 2020 Feb 1;86(2):221-230. doi: 10.1093/neuros/nyz046. Neurosurgery. 2020. PMID: 30877299 Free PMC article.
BACKGROUND: Hypertonic saline (HTS) and mannitol are effective in reducing intracranial pressure (ICP) after severe traumatic brain injury (TBI). ...METHODS: We performed a case-control study using prospectively collected data from the New York State T …
BACKGROUND: Hypertonic saline (HTS) and mannitol are effective in reducing intracranial pressure (ICP) after severe traumat …
Hypertonic Saline Treatment in Traumatic Brain Injury: A Systematic Review.
Mekonnen M, Ong V, Florence TJ, Mozaffari K, Mahgerefteh N, Rana S, Duong C, Plurad DS, Yang I. Mekonnen M, et al. World Neurosurg. 2022 Jun;162:98-110. doi: 10.1016/j.wneu.2022.03.056. Epub 2022 Mar 19. World Neurosurg. 2022. PMID: 35318155 Review.
Hypertonic saline (HTS) is a widely used adjunct in the treatment of traumatic brain injury (TBI). ...
Hypertonic saline (HTS) is a widely used adjunct in the treatment of traumatic brain injury (TBI). ...
Hypertonic Saline Versus Mannitol for Traumatic Brain Injury: A Systematic Review and Meta-analysis With Trial Sequential Analysis.
Schwimmbeck F, Voellger B, Chappell D, Eberhart L. Schwimmbeck F, et al. J Neurosurg Anesthesiol. 2021 Jan;33(1):10-20. doi: 10.1097/ANA.0000000000000644. J Neurosurg Anesthesiol. 2021. PMID: 31567726
BACKGROUND: Mannitol and hypertonic saline are widely used to treat raised intracranial pressure (ICP) after traumatic brain injury (TBI), but the clinical superiority of one over the other has not been demonstrated. ...There were also no significant d …
BACKGROUND: Mannitol and hypertonic saline are widely used to treat raised intracranial pressure (ICP) after traumatic …
Comparative Effectiveness of Mannitol Versus Hypertonic Saline in Patients With Traumatic Brain Injury: A CENTER-TBI Study.
van Veen E, Nieboer D, Kompanje EJO, Citerio G, Stocchetti N, Gommers D, Menon DK, Ercole A, Maas AIR, Lingsma HF, van der Jagt M. van Veen E, et al. J Neurotrauma. 2023 Jul;40(13-14):1352-1365. doi: 10.1089/neu.2022.0465. Epub 2023 May 11. J Neurotrauma. 2023. PMID: 37014076 Free article.
Increased intracranial pressure (ICP) is one of the most important modifiable and immediate threats to critically ill patients suffering from traumatic brain injury (TBI). Two hyperosmolar agents (HOAs), mannitol and hypertonic saline (HTS), are routin …
Increased intracranial pressure (ICP) is one of the most important modifiable and immediate threats to critically ill patients suffering fro …
Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury.
Kochanek PM, Adelson PD, Rosario BL, Hutchison J, Miller Ferguson N, Ferrazzano P, O'Brien N, Beca J, Sarnaik A, LaRovere K, Bennett TD, Deep A, Gupta D, Willyerd FA, Gao S, Wisniewski SR, Bell MJ; ADAPT Investigators. Kochanek PM, et al. JAMA Netw Open. 2022 Mar 1;5(3):e220891. doi: 10.1001/jamanetworkopen.2022.0891. JAMA Netw Open. 2022. PMID: 35267036 Free PMC article.
IMPORTANCE: Hyperosmolar agents are cornerstone therapies for pediatric severe traumatic brain injury. Guideline recommendations for 3% hypertonic saline (HTS) are based on limited numbers of patients, and no study to date has supported a recommendatio …
IMPORTANCE: Hyperosmolar agents are cornerstone therapies for pediatric severe traumatic brain injury. Guideline recommendatio …
Hypertonic saline use in neurocritical care for treating cerebral edema: A review of optimal formulation, dosing, safety, administration and storage.
Holden DN, Mucksavage JJ, Cokley JA, Kim KS, Tucker NL, Esordi MS, Cook AM. Holden DN, et al. Am J Health Syst Pharm. 2023 Mar 7;80(6):331-342. doi: 10.1093/ajhp/zxac368. Am J Health Syst Pharm. 2023. PMID: 36480317 Review.
PURPOSE: Current Neurocritical Care Society guidelines on the management of cerebral edema recommend hypertonic saline (HTS) over mannitol in some scenarios, but practical questions remain regarding the appropriate administration method, concentration/dose, monitori …
PURPOSE: Current Neurocritical Care Society guidelines on the management of cerebral edema recommend hypertonic saline (HTS) o …
401 results