Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 1
1998 1
1999 1
2000 2
2001 1
2002 1
2003 1
2008 2
2012 1
2014 1
2015 1
2017 2
2018 1
2019 1
2021 2
2022 1
2023 1
2024 3
2025 6
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

30 results

Results by year

Filters applied: . Clear all
Page 1
Did you mean immunol (442,553 results)?
Immunocal limits gliosis in mouse models of repetitive mild-moderate traumatic brain injury.
Koza LA, Pena C, Russell M, Smith AC, Molnar J, Devine M, Serkova NJ, Linseman DA. Koza LA, et al. Brain Res. 2023 Jun 1;1808:148338. doi: 10.1016/j.brainres.2023.148338. Epub 2023 Mar 24. Brain Res. 2023. PMID: 36966959 Free PMC article.
Populations that suffer rmTBIs largely go undiagnosed and untreated; therefore, we first examined the potential therapeutic effect of Immunocal long-term following rmTBI. Mice were treated with Immunocal prior to, during, and following rmTBI induced by controlled co …
Populations that suffer rmTBIs largely go undiagnosed and untreated; therefore, we first examined the potential therapeutic effect of Imm …
Immunocal and preservation of glutathione as a novel neuroprotective strategy for degenerative disorders of the nervous system.
Ross EK, Gray JJ, Winter AN, Linseman DA. Ross EK, et al. Recent Pat CNS Drug Discov. 2012 Dec;7(3):230-5. doi: 10.2174/157488912803252014. Recent Pat CNS Drug Discov. 2012. PMID: 22742422 Review.
This review discusses the capacity of a cystine-rich, whey protein supplement (Immunocal) to enhance the de novo synthesis of GSH in neurons, and highlights its potential as a novel therapeutic approach to mitigate the oxidative damage that underlies the pathogenesis of va …
This review discusses the capacity of a cystine-rich, whey protein supplement (Immunocal) to enhance the de novo synthesis of GSH in …
Immunocal(), a cysteine-rich whey protein, rescues reelin and reduces amyloid plaque burden in a transgenic amyloid-beta protein precursor (hAbetaPP(SweInd)) mouse model of Alzheimer's disease.
Sandberg A, Puttagunta S, Duval N, Fleming H, Koza L, Hieber K, Holsopple J, Reyna M, Paredes D, Linseman DA. Sandberg A, et al. J Alzheimers Dis. 2025 Jul;106(1):94-110. doi: 10.1177/13872877251338323. Epub 2025 May 5. J Alzheimers Dis. 2025. PMID: 40325994
We also assessed the long-term effects of Immunocal() by treating J20 mice from 3 months old to 12 months old. Long-term Immunocal() treatment preserved brain GSH and rescued Reelin mRNA and protein expression, while significantly reducing amyloid plaque formation i …
We also assessed the long-term effects of Immunocal() by treating J20 mice from 3 months old to 12 months old. Long-term Immunocal …
Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial.
Macfarlane S, Grimmer T, Teo K, O'Brien TJ, Woodward M, Grunfeld J, Mander A, Brodtmann A, Brew BJ, Morris P, Short C, Kurrle S, Lai R, Bharadwaj S, Drysdale P, Sturm J, Lewis SJG, Barton D, Kalafatis C, Sharif S, Perry R, Mannering N, MacSweeney JE, Pearson S, Evans C, Krishna V, Thompson A, Munisamy M, Bhatt N, Asher A, Connell S, Lynch J, Rutgers SM, Dautzenberg PL, Prins N, Oschmann P, Frölich L, Tacik P, Peters O, Wiltfang J, Henri-Bhargava A, Smith E, Pasternak S, Frank A, Chertkow H, Ingram J, Hsiung GR, Brittain R, Tartaglia C, Cohen S, Villa LM, Gordon E, Jubault T, Guizard N, Tucker A, Kaufmann WE, Jin K, Chezem WR, Missling CU, Sabbagh MN. Macfarlane S, et al. J Prev Alzheimers Dis. 2025 Jan;12(1):100016. doi: 10.1016/j.tjpad.2024.100016. Epub 2025 Jan 1. J Prev Alzheimers Dis. 2025. PMID: 39800452 Free PMC article. Clinical Trial.
Cysteine-rich whey protein isolate (Immunocal) ameliorates deficits in the GFAP.HMOX1 mouse model of schizophrenia.
Song W, Tavitian A, Cressatti M, Galindez C, Liberman A, Schipper HM. Song W, et al. Free Radic Biol Med. 2017 Sep;110:162-175. doi: 10.1016/j.freeradbiomed.2017.05.025. Epub 2017 Jun 8. Free Radic Biol Med. 2017. PMID: 28603087
Immunocal attenuated many of the behavioral, neurochemical and redox abnormalities observed in GFAP.HMOX1 mice. ...Whey protein isolate supplementation (Immunocal) may constitute a safe and effective modality for the management of schizophrenia, an unmet clinical im …
Immunocal attenuated many of the behavioral, neurochemical and redox abnormalities observed in GFAP.HMOX1 mice. ...Whey protein isola …
The cysteine-rich whey protein supplement, Immunocal, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact.
Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L, Huber K, Serkova NJ, Linseman DA. Ignowski E, et al. Free Radic Biol Med. 2018 Aug 20;124:328-341. doi: 10.1016/j.freeradbiomed.2018.06.026. Epub 2018 Jun 27. Free Radic Biol Med. 2018. PMID: 29940352 Free PMC article.
Here, we tested a whey protein supplement, Immunocal, for its potential to enhance resilience to TBI. Immunocal is a non-denatured whey protein preparation which has been shown to act as a cysteine delivery system to increase levels of the essential antioxidant glut …
Here, we tested a whey protein supplement, Immunocal, for its potential to enhance resilience to TBI. Immunocal is a non-denat …
A Cystine-Rich Whey Supplement (Immunocal) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione.
Winter AN, Ross EK, Daliparthi V, Sumner WA, Kirchhof DM, Manning E, Wilkins HM, Linseman DA. Winter AN, et al. Oxid Med Cell Longev. 2017;2017:3103272. doi: 10.1155/2017/3103272. Epub 2017 Aug 15. Oxid Med Cell Longev. 2017. PMID: 28894506 Free PMC article.
The neuroprotective effects of Immunocal were blocked by inhibition of gamma-glutamyl-cysteine ligase, demonstrating dependence on de novo GSH synthesis. These findings indicate that sustaining GSH with Immunocal significantly protects neurons against diverse induce …
The neuroprotective effects of Immunocal were blocked by inhibition of gamma-glutamyl-cysteine ligase, demonstrating dependence on de …
Effect of cysteine-rich whey protein (immunocal) supplementation in combination with resistance training on muscle strength and lean body mass in non-frail elderly subjects: a randomized, double-blind controlled study.
Karelis AD, Messier V, Suppère C, Briand P, Rabasa-Lhoret R. Karelis AD, et al. J Nutr Health Aging. 2015 May;19(5):531-6. doi: 10.1007/s12603-015-0442-y. J Nutr Health Aging. 2015. PMID: 25923482 Free PMC article. Clinical Trial.
We hypothesized that the cysteine-rich whey protein (Immunocal) group would experience a greater increase in muscle strength and lean body mass versus the control group (casein). ...The experimental group received a cysteine-rich whey protein isolate (Immunocal) (20 …
We hypothesized that the cysteine-rich whey protein (Immunocal) group would experience a greater increase in muscle strength and lean …
A Cystine-Rich Whey Supplement (Immunocal()) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
Ross EK, Winter AN, Wilkins HM, Sumner WA, Duval N, Patterson D, Linseman DA. Ross EK, et al. Antioxidants (Basel). 2014 Dec 12;3(4):843-65. doi: 10.3390/antiox3040843. Antioxidants (Basel). 2014. PMID: 26785244 Free PMC article.
Immunocal() is rich in the GSH precursor, cystine, and is therefore capable of bolstering GSH content. ...However, Immunocal() did not extend survival, likely due to its inability to preserve the mitochondrial GSH pool in spinal cord. ...
Immunocal() is rich in the GSH precursor, cystine, and is therefore capable of bolstering GSH content. ...However, Immunocal() …
Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research.
Smith EE, Phillips NA, Feldman HH, Borrie M, Ganesh A, Henri-Bhargava A, Desmarais P, Frank A, Badhwar A, Barlow L, Bartha R, Best S, Bethell J, Bhangu J, Black SE, Bocti C, Bronskill SE, Burhan AM, Calon F, Camicioli R, Campbell B, Collins DL, Dadar M, DeMarco ML, Ducharme S, Duchesne S, Einstein G, Fisk JD, Gawryluk JR, Grossman L, Ismail Z, Itzhak I, Joshi M, Harrison A, Kröger E, Kumar S, Laforce R, Lanctot KL, Lau M, Lee L, Masellis M, Massoud F, Mitchell SB, Montero-Odasso M, Myers Barnett K, Nygaard HB, Pasternak SH, Peters J, Rajah MN, Robillard JM, Rockwood K, Rosa-Neto P, Seitz DP, Soucy JP, Trenaman SC, Wellington CL, Zadem A, Chertkow H; Canadian Consortium on Neurodegeneration in Aging Investigators. Smith EE, et al. J Prev Alzheimers Dis. 2025 Mar;12(3):100068. doi: 10.1016/j.tjpad.2025.100068. Epub 2025 Jan 31. J Prev Alzheimers Dis. 2025. PMID: 39893139 Free PMC article. Review.
30 results