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Showing results for indap gamma
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Assessing the evolutionary impact of amino acid mutations in the human genome.
Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD. Boyko AR, et al. PLoS Genet. 2008 May 30;4(5):e1000083. doi: 10.1371/journal.pgen.1000083. PLoS Genet. 2008. PMID: 18516229 Free PMC article.
In both populations, the patterns of variation are consistent with a leptokurtic distribution of selection coefficients (e.g., gamma or log-normal) peaked near neutrality. Specifically, we predict 27-29% of amino acid changing (nonsynonymous) mutations are neutral or nearl …
In both populations, the patterns of variation are consistent with a leptokurtic distribution of selection coefficients (e.g., gamma …
Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergence.
Torgerson DG, Boyko AR, Hernandez RD, Indap A, Hu X, White TJ, Sninsky JJ, Cargill M, Adams MD, Bustamante CD, Clark AG. Torgerson DG, et al. PLoS Genet. 2009 Aug;5(8):e1000592. doi: 10.1371/journal.pgen.1000592. Epub 2009 Aug 7. PLoS Genet. 2009. PMID: 19662163 Free PMC article.
Moreover, there is an excess of fixed differences that cannot be explained by a Gamma model of deleterious fitness effects, suggesting the presence of positive selection on CNCs. ...
Moreover, there is an excess of fixed differences that cannot be explained by a Gamma model of deleterious fitness effects, suggestin …