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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 3
1986 1
1988 2
1989 1
1993 3
1994 2
1995 1
1996 3
1997 2
1998 4
1999 1
2000 2
2001 6
2002 7
2003 6
2004 5
2005 3
2006 6
2007 5
2008 1
2009 7
2010 9
2011 6
2012 13
2013 13
2014 21
2015 13
2016 14
2017 14
2018 19
2019 9
2020 12
2021 15
2022 11
2023 24
2024 9

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252 results

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Page 1
MEN1 mutations mediate clinical resistance to menin inhibition.
Perner F, Stein EM, Wenge DV, Singh S, Kim J, Apazidis A, Rahnamoun H, Anand D, Marinaccio C, Hatton C, Wen Y, Stone RM, Schaller D, Mowla S, Xiao W, Gamlen HA, Stonestrom AJ, Persaud S, Ener E, Cutler JA, Doench JG, McGeehan GM, Volkamer A, Chodera JD, Nowak RP, Fischer ES, Levine RL, Armstrong SA, Cai SF. Perner F, et al. Nature. 2023 Mar;615(7954):913-919. doi: 10.1038/s41586-023-05755-9. Epub 2023 Mar 15. Nature. 2023. PMID: 36922589 Free PMC article. Clinical Trial.
Here we identified somatic mutations in MEN1 at the revumenib-menin interface in patients with acquired resistance to menin inhibition. Consistent with the genetic data in patients, inhibitor-menin interface mutations represent a conserved mechanism of therapeutic r …
Here we identified somatic mutations in MEN1 at the revumenib-menin interface in patients with acquired resistance to menin inhibitio …
NEMO reshapes the alpha-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.
Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakamura K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF. Furthmann N, et al. Nat Commun. 2023 Dec 19;14(1):8368. doi: 10.1038/s41467-023-44033-0. Nat Commun. 2023. PMID: 38114471 Free PMC article.
Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.
Hartmann M, Huber J, Kramer JS, Heering J, Pietsch L, Stark H, Odadzic D, Bischoff I, Fürst R, Schröder M, Akutsu M, Chaikuad A, Dötsch V, Knapp S, Biondi RM, Rogov VV, Proschak E. Hartmann M, et al. J Med Chem. 2021 Apr 8;64(7):3720-3746. doi: 10.1021/acs.jmedchem.0c01564. Epub 2021 Mar 26. J Med Chem. 2021. PMID: 33769048
Image management systems.
ASGE Technology Committee; Murad FM, Banerjee S, Barth BA, Bhat YM, Chauhan SS, Gottlieb KT, Konda V, Maple JT, Pfau P, Pleskow D, Siddiqui UD, Tokar JL, Wang A, Rodriguez SA. ASGE Technology Committee, et al. Gastrointest Endosc. 2014 Jan;79(1):15-22. doi: 10.1016/j.gie.2013.07.048. Epub 2013 Nov 14. Gastrointest Endosc. 2014. PMID: 24239253 Review. No abstract available.
3D-printed mouthpiece adapter for sampling exhaled breath in medical applications.
Pham YL, Beauchamp J, Clement A, Wiegandt F, Holz O. Pham YL, et al. 3D Print Med. 2022 Aug 9;8(1):27. doi: 10.1186/s41205-022-00150-y. 3D Print Med. 2022. PMID: 35943600 Free PMC article.
The growing use of 3D printing in the biomedical sciences demonstrates its utility for a wide range of research and healthcare applications, including its potential implementation in the discipline of breath analysis to overcome current limitations and substantial costs of commer …
The growing use of 3D printing in the biomedical sciences demonstrates its utility for a wide range of research and healthcare applications, …
A dynamic interface between ubiquitylation and cAMP signaling.
Rinaldi L, Sepe M, Donne RD, Feliciello A. Rinaldi L, et al. Front Pharmacol. 2015 Sep 4;6:177. doi: 10.3389/fphar.2015.00177. eCollection 2015. Front Pharmacol. 2015. PMID: 26388770 Free PMC article. Review.
Multivalent complexes are assembled by AKAPs and include signaling enzymes, mRNAs, adapter molecules, receptors and ion channels. A novel development derived from the molecular analysis of these complexes nucleated by AKAPs is represented by the presence of components of t …
Multivalent complexes are assembled by AKAPs and include signaling enzymes, mRNAs, adapter molecules, receptors and ion channels. A n …
The remarkable multivalency of the Hsp70 chaperones.
Zuiderweg ER, Hightower LE, Gestwicki JE. Zuiderweg ER, et al. Cell Stress Chaperones. 2017 Mar;22(2):173-189. doi: 10.1007/s12192-017-0776-y. Epub 2017 Feb 20. Cell Stress Chaperones. 2017. PMID: 28220454 Free PMC article. Review.
To carry out this task, they employ a large number of cochaperones and adapter proteins. Here, we review what is known about the interaction between the chaperones and partners, with a strong slant toward structural biology. Hsp70s in general, and Hsc70 (HSPA8) in particul …
To carry out this task, they employ a large number of cochaperones and adapter proteins. Here, we review what is known about the inte …
Rational Design, Binding Studies, and Crystal-Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14-3-3zeta Adapter Protein.
Ehlers M, Grad JN, Mittal S, Bier D, Mertel M, Ohl L, Bartel M, Briels J, Heimann M, Ottmann C, Sanchez-Garcia E, Hoffmann D, Schmuck C. Ehlers M, et al. Chembiochem. 2018 Mar 16;19(6):591-595. doi: 10.1002/cbic.201700588. Epub 2018 Feb 15. Chembiochem. 2018. PMID: 29282826
Their function as hub for intracellular communication can explain why these adapter proteins are associated with a wide range of diseases. How they control the various cellular mechanisms is still unclear, but it is assumed that the dimeric nature of the 14-3-3 proteins pl …
Their function as hub for intracellular communication can explain why these adapter proteins are associated with a wide range of dise …
Arrestins in the Cardiovascular System: An Update.
Lymperopoulos A. Lymperopoulos A. Prog Mol Biol Transl Sci. 2018;159:27-57. doi: 10.1016/bs.pmbts.2018.07.003. Epub 2018 Aug 9. Prog Mol Biol Transl Sci. 2018. PMID: 30340788 Review.
Three major functional roles for the two ubiquitous G protein-coupled receptor (GPCR) adapter proteins, betaarrestin1 and -2 (also known as Arrestin2 and -3, respectively), have been described: (a) functional desensitization, i.e., G-protein uncoupling from the receptor, ( …
Three major functional roles for the two ubiquitous G protein-coupled receptor (GPCR) adapter proteins, betaarrestin1 and -2 (also kn …
p62 at the interface of autophagy, oxidative stress signaling, and cancer.
Nezis IP, Stenmark H. Nezis IP, et al. Antioxid Redox Signal. 2012 Sep 1;17(5):786-93. doi: 10.1089/ars.2011.4394. Epub 2012 Jan 11. Antioxid Redox Signal. 2012. PMID: 22074114 Review.
SIGNIFICANCE: Sequestosome 1 (p62/SQSTM1) is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. ...
SIGNIFICANCE: Sequestosome 1 (p62/SQSTM1) is a multifunctional adapter protein implicated in selective autophagy, cell signaling path …
252 results