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Page 1
Showing results for adomet
Search for kadomet instead (1 results)
AdoMet analog synthesis and utilization: current state of the art.
Huber TD, Johnson BR, Zhang J, Thorson JS. Huber TD, et al. Curr Opin Biotechnol. 2016 Dec;42:189-197. doi: 10.1016/j.copbio.2016.07.005. Epub 2016 Aug 6. Curr Opin Biotechnol. 2016. PMID: 27506965 Free PMC article. Review.
S-Adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogate …
S-Adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic an …
S-adenosylmethionine in liver health, injury, and cancer.
Lu SC, Mato JM. Lu SC, et al. Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011. Physiol Rev. 2012. PMID: 23073625 Free PMC article. Review.
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. ...Patients with chronic liver disease have reduced MAT activity and AdoMet levels. …
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all m …
Structural diversity in the AdoMet radical enzyme superfamily.
Dowling DP, Vey JL, Croft AK, Drennan CL. Dowling DP, et al. Biochim Biophys Acta. 2012 Nov;1824(11):1178-95. doi: 10.1016/j.bbapap.2012.04.006. Epub 2012 Apr 28. Biochim Biophys Acta. 2012. PMID: 22579873 Free PMC article. Review.
AdoMet radical enzymes are involved in processes such as cofactor biosynthesis, anaerobic metabolism, and natural product biosynthesis. These enzymes utilize the reductive cleavage of S-adenosylmethionine (AdoMet) to afford l-methionine and a transient …
AdoMet radical enzymes are involved in processes such as cofactor biosynthesis, anaerobic metabolism, and natural product biosynthesi …
AdoMet-dependent methylation, DNA methyltransferases and base flipping.
Cheng X, Roberts RJ. Cheng X, et al. Nucleic Acids Res. 2001 Sep 15;29(18):3784-95. doi: 10.1093/nar/29.18.3784. Nucleic Acids Res. 2001. PMID: 11557810 Free PMC article. Review.
Twenty AdoMet-dependent methyltransferases (MTases) have been characterized structurally by X-ray crystallography and NMR. ...The MTases share a common core structure of a mixed seven-stranded beta-sheet (6 downward arrow 7 upward arrow 5 downward arrow 4 downward arrow 1 …
Twenty AdoMet-dependent methyltransferases (MTases) have been characterized structurally by X-ray crystallography and NMR. ...The MTa …
Nucleoside-modified AdoMet analogues for differential methyltransferase targeting.
Cornelissen NV, Michailidou F, Muttach F, Rau K, Rentmeister A. Cornelissen NV, et al. Chem Commun (Camb). 2020 Feb 18;56(14):2115-2118. doi: 10.1039/c9cc07807j. Epub 2020 Jan 23. Chem Commun (Camb). 2020. PMID: 31970375 Free PMC article.
Methyltransferases (MTases) modify a wide range of biomolecules using S-adenosyl-l-methionine (AdoMet) as the cosubstrate. Synthetic AdoMet analogues are powerful tools to site-specifically introduce a variety of functional groups and exhibit potential to be convert …
Methyltransferases (MTases) modify a wide range of biomolecules using S-adenosyl-l-methionine (AdoMet) as the cosubstrate. Synthetic …
Radical AdoMet enzymes in complex metal cluster biosynthesis.
Duffus BR, Hamilton TL, Shepard EM, Boyd ES, Peters JW, Broderick JB. Duffus BR, et al. Biochim Biophys Acta. 2012 Nov;1824(11):1254-63. doi: 10.1016/j.bbapap.2012.01.002. Epub 2012 Jan 14. Biochim Biophys Acta. 2012. PMID: 22269887 Review.
Radical S-adenosylmethionine (AdoMet) enzymes comprise a large superfamily of proteins that engage in a diverse series of biochemical transformations through generation of the highly reactive 5'-deoxyadenosyl radical intermediate. ...Radical AdoMet enz …
Radical S-adenosylmethionine (AdoMet) enzymes comprise a large superfamily of proteins that engage in a diverse series …
Determining Redox Potentials of the Iron-Sulfur Clusters of the AdoMet Radical Enzyme Superfamily.
Maiocco SJ, Walker LM, Elliott SJ. Maiocco SJ, et al. Methods Enzymol. 2018;606:319-339. doi: 10.1016/bs.mie.2018.06.002. Epub 2018 Jul 5. Methods Enzymol. 2018. PMID: 30097097 Review.
While protein film electrochemistry (PFE) has proven to be an effective tool in the interrogation of redox cofactors and assessing the electrocatalytic activity of many different enzymes, recently it has been proven to be useful for the study of the redox potentials of the cofact …
While protein film electrochemistry (PFE) has proven to be an effective tool in the interrogation of redox cofactors and assessing the elect …
Control of radical chemistry in the AdoMet radical enzymes.
Duschene KS, Veneziano SE, Silver SC, Broderick JB. Duschene KS, et al. Curr Opin Chem Biol. 2009 Feb;13(1):74-83. doi: 10.1016/j.cbpa.2009.01.022. Epub 2009 Mar 9. Curr Opin Chem Biol. 2009. PMID: 19269883 Free PMC article. Review.
The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosylmethionine (SAM or AdoMet) to initiate a diverse set of radical-mediated reactions. ...This review focuses on the accumulating ev …
The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosyl …
AdoMet triggers apoptosis in head and neck squamous cancer by inducing ER stress and potentiates cell sensitivity to cisplatin.
Mosca L, Pagano M, Ilisso CP, Cave DD, Desiderio V, Mele L, Caraglia M, Cacciapuoti G, Porcelli M. Mosca L, et al. J Cell Physiol. 2019 Aug;234(8):13277-13291. doi: 10.1002/jcp.28000. Epub 2018 Dec 21. J Cell Physiol. 2019. PMID: 30575033
AdoMet also exhibits antiproliferative and proapoptotic activities in different cancer cells. However, the molecular mechanisms underlying the effects exerted by AdoMet have only been partially studied. In the current study, we evaluated the antiproliferative effect …
AdoMet also exhibits antiproliferative and proapoptotic activities in different cancer cells. However, the molecular mechanisms under …
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